Autologous Fat Graft: Not Only an Aesthetic Solution

  • Jacopo Scala University of Rome G. Marconi, Rome, Italia
  • Aleksandra Vojvodic Department of Dermatology and Venereology, Military Medical Academy, Belgrade, Serbia
  • Petar Vojvodic Clinic for Psychiatric Disorders “Dr. Laza Lazarevic”, Belgrade, Serbia
  • Tatjana Vlaskovic-Jovicevic Clinic for Psychiatric Disorders “Dr. Laza Lazarevic”, Belgrade, Serbia
  • Zorica Peric-Hajzler Military Medical Academy, Belgrade, Serbia
  • Dusica Matovic Military Medical Academy, Belgrade, Serbia
  • Sanja Dimitrijevic Department of Gynecology, Military Medical Academy, Belgrade, Serbia
  • Jovana Vojvodic Clinic for Psychiatric Disorders “Dr. Laza Lazarevic”, Belgrade, Serbia
  • Goran Sijan Clinic for Plastic Surgery and Burns, Military Medical Academy, Belgrade, Serbia
  • Nenad Stepic Chief of Clinic for Plastic Surgery and Burns, Military Medical Academy, Belgrade, Serbia
  • Uwe Wollina Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Dresden, Germany
  • Michael Tirant University Guglielmo Marconi, Rome, Italy
  • Van Thuong Nguyen Vietnam National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Massimo Fioranelli Department of Nuclear Physics, sub-nuclear and radiation, G. Marconi University, Rome, Italy
  • Torello Lotti Department of Dermatology, University of G. Marconi, Rome, Italy
Keywords: autologous, fat, fat graft, aesthetic

Abstract

Subcutaneous adipose tissue was defined as the “perfect filler†as is soft and malleable and is usually enough present in the body for correcting volume defects and small remodelling purposes. The first attempts to implant autologous adipose tissue dates back to the end of the twentieth century, and with the refinement of harvesting, processing and replanting techniques today a uniform and predictable amount of survival rate were achieved. Those improvements have led to wider use of autologous fat grafts in many medical specialities not only in aesthetic or reconstructive treatments.

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References

Billings JE, May JJ. Historical review and present status of free fat graft auto transplantation in plastic and reconstructive surgery. Plast Reconstr Surg. 1989; 83:368-381. https://doi.org/10.1097/00006534-198902000-00033 PMid:2643129

Coleman SR. Structural fat grafts: the ideal filler? Clin Plast Surg. 2001; 28:111.

Coleman SR. Hand rejuvenation with structural fat grafting. Plast Reconstr Surg. 2002; 110:1731-45. https://doi.org/10.1097/00006534-200212000-00017 PMid:12447057

Coleman SR. Long-term survival of fat transplants: controlled demonstrations. Aesthet Plast Surg. 1995; 19:421. https://doi.org/10.1007/BF00453875

Peer LA. Loss of weight and volume in human fat graft, with postulation of a cell survival theory. Plast Reconstr Surg. 1950; 5:217. https://doi.org/10.1097/00006534-195003000-00002

Tremolada C, Palmieri G, Ricordi C. Adipocyte transplantation and stem cells: plastic surgery meets regenerative medicine. Cell transplant. 2010; 19(10):1217-23. https://doi.org/10.3727/096368910X507187 PMid:20444320

von Heimburg D, Hemmrich K, Haydarlioglu S, Staiger H, Pallua N. Comparison of viable cell yield from excised versus aspirated adipose tissue. Cells Tissues Organs. 2004; 178(2):87-92. https://doi.org/10.1159/000081719 PMid:15604532

Wolter TP, von Heimburg D, Stoffels I, Groeger A, Pallua N. Cryopreservation of mature human adipocytes: in vitro measurement of viability. Ann Plast Surg. 2005; 55(4):408-13. https://doi.org/10.1097/01.sap.0000181345.56084.7d PMid:16186709

Eto H, Kato H, Suga H, Aoi N, Doi K, Kuno S, Yoshimura K. The fate of adipocytes after nonvascularized fat grafting: evidence of early death and replacement of adipocytes. Plast Reconstr Surg. 2012; 129(5):1081-92. https://doi.org/10.1097/PRS.0b013e31824a2b19 PMid:22261562

Kato H, Mineda K, Eto H, Doi K, Kuno S, Kinoshita K, Kanayama K, Yoshimura K. Degeneration, regeneration, and cicatrization after fat grafting: dynamic total tissue remodeling during the first 3 months. Plastic and reconstructive surgery. 2014; 133(3):303e-13e.

J Salgado A, L Reis R, Sousa N, M Gimble J. Adipose tissue derived stem cells secretome: soluble factors and their roles in regenerative medicine. Current stem cell research & therapy. 2010; 5(2):103-10. https://doi.org/10.2174/157488810791268564

Cervelli V, Scioli MG, Gentile P, Doldo E, Bonanno E, Spagnoli LG, Orlandi A. Plateletâ€rich plasma greatly potentiates insulinâ€induced adipogenic differentiation of human adiposeâ€derived stem cells through a serine/threonine kinase Aktâ€dependent mechanism and promotes clinical fat graft maintenance. Stem cells translational medicine. 2012; 1(3):206-20. https://doi.org/10.5966/sctm.2011-0052 PMid:23197780 PMCid:PMC3659852

Simonacci F, Bertozzi N, Raposio E. Off-label use of adipose-derived stem cells. Annals of medicine and surgery. 2017; 24:44-51. https://doi.org/10.1016/j.amsu.2017.10.023 PMid:29123656 PMCid:PMC5671395

Justesen J, Pedersen SB, Stenderup K, Kassem M. Subcutaneous adipocytes can differentiate into bone-forming cells in vitro and in vivo. Tissue engineering. 2004; 10(3-4):381-91. https://doi.org/10.1089/107632704323061744 PMid:15165455

Wollina U, Goldman A, Abdel-Naser MB, Philipp-Dormston WG.Adipose tissue, fillers, and skin tightening. Dermatol Ther. 2019; 32(2). https://doi.org/10.1111/dth.12626 PMid:30175548

Uyulmaz S, Sanchez Macedo N, Rezaeian F, Giovanoli P, LindenblattN.Nanofat Grafting for Scar Treatment and Skin Quality Improvement. Aesthet Surg J. 2018; 38(4):421-428. https://doi.org/10.1093/asj/sjx183 PMid:29365061

Bellini E, Grieco MP, Raposio E. The science behind autologous fat grafting. Ann Med Surg. 2017; 24:65-73. https://doi.org/10.1016/j.amsu.2017.11.001 PMid:29188051 PMCid:PMC5694962

Virzì F, et al .Combined platelet-rich plasma and lipofilling treatment provides greatimprovement in facial skin-induced lesion regeneration for scleroderma patients. Stem Cell Res Ther. 2017; 8(1):236. https://doi.org/10.1186/s13287-017-0690-3 PMid:29058626 PMCid:PMC5651639

Gheisari M, Ahmadzadeh A, Nobari N, Iranmanesh B, Mozafari N. Autologous Fat Grafting in the Treatment of Facial Scleroderma. Dermatol Res Pract. 2018; 2018:6568016. https://doi.org/10.1155/2018/6568016 PMid:30154838 PMCid:PMC6093005

Lee G, Hunter-Smith DJ, Rozen WM. Autologous fat grafting in keloids and hypertrophic scars: a review. Scars Burn Heal. 2017; 3:2059513117700157. https://doi.org/10.1177/2059513117700157 PMid:29799555 PMCid:PMC5965318

Mojallal A, Veber M, Shipkov C, Ghetu N, Foyatier JL, Braye F. Analysis of a series of autologous fat tissue transfer for lower limb atrophies. Annals of plastic surgery. 2008; 61(5):537-43. https://doi.org/10.1097/SAP.0b013e318164088f PMid:18948782

Zimmermann S, Fakin RM, Giesen T, Giovanoli P, Calcagni M. Stromal vascular fraction-enriched fat grafting for the treatment of symptomatic end-neuromata. JoVE (Journal of Visualized Experiments). 2017; (129):e55962. https://doi.org/10.3791/55962 PMid:29286436

Segreto F, Marangi GF, Persichetti P. Autologous Fat Grafting as a Novel Antiestrogen Vehicle for the Treatment of Breast Cancer. Plast Reconstr Surg. 2018; 141(6):965e-966e. https://doi.org/10.1097/PRS.0000000000004387 PMid:29608518

Baum SH, Mohr C. Autologous dermis-fat grafts in head and neck patients: Indications andevaluation in reconstructive surgery. J Craniomaxillofac Surg. 2018; 46(10):1834-1842. https://doi.org/10.1016/j.jcms.2018.07.009 PMid:30097407

Lotti TM, Hercogová J, Schwartz RA, Tsampau D, Korobko I, Pietrzak A, Mitrevska NT, Valle Y, Buggiani G. Treatments of vitiligo: what's new at the horizon. Dermatologic Ther. 2012; 25(1):S32-40. https://doi.org/10.1111/dth.12011 PMid:23237036

Goren A, BolanÄa Ž, Lotti T, Å itum M. Novel technique for repigmentation of senescence grey hair. Dermatol Ther. 2017; 30(2). https://doi.org/10.1111/dth.12436 PMid:27917579

Gentile P, Garcovich S. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysison Cell Growth and Hair Follicle Development. Cells. 2019; 8(5). https://doi.org/10.3390/cells8050466 PMid:31100937 PMCid:PMC6562814

Published
2019-08-30
How to Cite
1.
Scala J, Vojvodic A, Vojvodic P, Vlaskovic-Jovicevic T, Peric-Hajzler Z, Matovic D, Dimitrijevic S, Vojvodic J, Sijan G, Stepic N, Wollina U, Tirant M, Nguyen VT, Fioranelli M, Lotti T. Autologous Fat Graft: Not Only an Aesthetic Solution. Open Access Maced J Med Sci [Internet]. 2019Aug.30 [cited 2020Oct.23];7(18):2961-3. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2019.781

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