Clinical Applications of System Regulation Medicine

  • Massimo Fioranelli Department of Nuclear Physics, sub-nuclear and radiation, G. Marconi University, Rome, Italy
  • Alireza Sepehri Department of Nuclear Physics, Sub-nuclear and Radiation, G. Marconi University, Rome, Italy
  • Maria Grazia Roccia Department of Nuclear Physics, Sub-nuclear and Radiation, G. Marconi University, Rome, Italy
  • Cota Linda Department of Nuclear Physics, Sub-nuclear and Radiation, G. Marconi University, Rome, Italy
  • Chiara Rossi Department of Nuclear Physics, Sub-nuclear and Radiation, G. Marconi University, Rome, Italy
  • Amos Dawodo Department of Nuclear Physics, Sub-nuclear and Radiation, G. Marconi University, Rome, Italy
  • Petar Vojvodic Clinic for Psychiatric Disorders “Dr. Laza Lazarevic”, Belgrade, Serbia
  • Jacopo Lotti Department of Nuclear Physics, Sub-nuclear and Radiation, G. Marconi University, Rome, Italy
  • Victoria Barygina Department of Biomedical Experimental and Clinical Sciences, University of Florence, Florence, Italy
  • Aleksandra Vojvodic Department of Dermatology and Venereology, Military Medical Academy, Belgrade, Serbia
  • Uwe Wollina Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Dresden, Germany
  • Michael Tirant G. Marconi University, Rome, Italy
  • Thuong Nguyen Van Vietnam National Hospital of Dermatology and Venereology, Hanoi, Vietnam
  • Torello Lotti University of Rome G. Marconi, Rome, Italia
Keywords: Bioregulatory Systems Medicine, preclinical, networks

Abstract

Increasing incidence and poor outcome of chronic non-communicable diseases in western population would require a paradigm shift in the treatments. Guidelines-based medical approaches continue to be the standard rule in clinical practice, although only less than 15% of them are based on high-quality research. For each person who benefits from the 10 best-selling drugs in the USA, a number between 4 and 25 has no one beneficial effect.

The reductionist linear medicine method does not offer solutions in the non-manifest preclinical stage of the disease when it would still be possible to reverse the pathological progression and the axiom "a drug, a target, a symptom" are still inconclusive. Needs additional tools to address these challenges.

System Medicine considers the disease as a dysregulation of the biological networks that changes throughout the evolution of the pathological process and with the comorbidities development. The strength of the networks indicates their ability to withstand dysregulations during the perturbation phases, returning to the state of stability. The treatment of dysregulated networks before the symptomatological manifestation emerges offers the possibility of treating and preventing pathologies in the preclinical phase and potentially reversing the pathological process, stopping it or preventing comorbidities. Furthermore, treating shared networks instead of individual phenotypic symptoms can reduce drug use, offering a solution to the problem of ineffective drug use.

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Author Biography

Torello Lotti, University of Rome G. Marconi, Rome, Italia

Prof. Lotti is Full Professor of the Dermatology and Venereology at University of Studies Guglielmo Marconi, Rome, Italy. He is Honorary Professor of Dermatology - China Medical University Shenyang (2011), Lecturer at the New York Academy of Sciences "Howard Fox Memorial Lecture" (14 March 2012 - New York, NY – USA), and Chair, Executive Scientific Committee Vitiligo Research Foundation, New York , NY , USA. He is President of the World Health Academy, Dermatology since 2013. He has been Full Professor of the Dermatology and Venereology Division at University of Florence School of Medicine, Florence, Italy, from 2006 to 2010. He is Visiting Professor in six International Universities worldwide, and Key Note Lecturer in several international dermatology Societies. His activities in serving Dermatology have been numerous: President of the Italian Society of Dermatology and Venereology (SIDeMaST , 2009-2010) and President of the International Society of Dermatology ( ISD, 2009-2010), President of the European Society for Cosmetic and Aesthetic Dermatology (2003-2004), Editor in Chief of the Journal of the European Academy of Dermatology and Venereology (1992-2002) , Editor "Therapeutic Hotline"- Dermatologic Therapy (2007-)and served as Editor in Chief of the Giornale Italiano di Dermatologia in the period of presidency of the Societa' Italiana di Dermatologia (2009-2010). He has been President of numerous international congresses and is currently Editor in Chief of the Giornale Italiano di Dermatologia e Venereologia ( 2010-2020 ). He is Ordinary Member of the main Scientific Societies worldwide (EADV, SIDEV , ESDR , ISD, AAD, SID) and Honorary Member of several Scientific Societies of the Dermatology field. Moreover, he is a Scientific reviewer of ten sectorial journals, among which are the British Journal of Dermatology, Journal of Investigative Dermatology, Journal of the American Academy of Dermatology , Dermatologic Therapy. He has authored 1054 scientific publications (393 peer reviewed articles, 288 books chapters e 365 abstracts). For more information, see www.torellolotti.it

References

Cesario A, Cazzola M, Lauro D, Frustaci A, Neri M. A systems medicine clinical platform for understanding and managing non-communicable diseases. Curr Pharm Des. 2014; 20(38):5945-5956. https://doi.org/10.2174/1381612820666140314130449 PMid:24641232

Bland JS, Minich DM, Eck BM. A Systems Medicine approach: translating emerging science into individualized wellness. Adv Med. 2017; 2017:1718957. https://doi.org/10.1155/2017/1718957 PMid:29164177 PMCid:PMC5661085

Kramer F, Just S, Zeller T. New perspectives: Systems Medicine in cardiovascular disease. BMC Syst Biol. 2018; 12(1):1-13. https://doi.org/10.1186/s12918-018-0579-5 PMid:29699591 PMCid:PMC5921396

Trachana K, Bargaje R, Glusman G, Price ND, Huang S, Hood LE. Taking Systems Medicine to heart. Circ Res. 2018; 122(9):1276-1289. https://doi.org/10.1161/CIRCRESAHA.117.310999 PMid:29700072 PMCid:PMC5926821

Peters U, Dixon AE, Forno E. Obesity and asthma. J Allergy Clin Immunol. 2018; 141(4):1169-1179. https://doi.org/10.1016/j.jaci.2018.02.004 PMid:29627041 PMCid:PMC5973542

Faienza MF, Wang DQH, Fruhbeck G, Garruti G, Portincasa P. The dangerous link between childhood and adulthood predictors of obesity and metabolic syndrome. Intern Emerg Med. 2016; 11(2):175-182. https://doi.org/10.1007/s11739-015-1382-6 PMid:26758061

Nutten S. Atopic dermatitis: global epidemiology and risk factors. Ann Nutr Metab. 2015; 66(1):8-16. https://doi.org/10.1159/000370220 PMid:25925336

Isaevska E, Manasievska M, Alessi D, et al. Cancer incidence rates and trends among children and adolescents in Piedmont, 1967-2011. PLoS One. 2017; 12(7):e0181805. https://doi.org/10.1371/journal.pone.0181805 PMid:28742150 PMCid:PMC5524393

Courvalin P. Why is antibiotic resistance a deadly emerging disease? Clin Microbiol Infect. 2016; 22(5):405-407. https://doi.org/10.1016/j.cmi.2016.01.012 PMid:26806259

Turner MC, Vineis P, Seleiro E, et al. EXPOsOMICS: final policy workshop and stakeholder consultation. BMC Public Health. 2018; 18(1):260. https://doi.org/10.1186/s12889-018-5160-z PMid:29448939 PMCid:PMC5815236

Frieri M, Kumar K, Boutin A. Antibiotic resistance. J Infect Public Health. 2017; 10(4):369-378. https://doi.org/10.1016/j.jiph.2016.08.007 PMid:27616769

Gustafsson M, Nestor CE, Zhang H, et al. Modules, networks and systems medicine for understanding disease and aiding diagnosis. Genome Med. 2014; 6(10):82. https://doi.org/10.1186/s13073-014-0082-6 PMid:25473422 PMCid:PMC4254417

Schork NJ. Time for one-person trials. Nature. 2015; 520:609-610. https://doi.org/10.1038/520609a PMid:25925459

Charlesworth CJ, Smit E, Lee DSH, Alramadhan F, Odden MC. Polypharmacy among adults aged 65 years and older in the United States: 1988-2010. J Gerontol A Biol Sci Med Sci. 2015; 70(8):989-995. https://doi.org/10.1093/gerona/glv013 PMid:25733718 PMCid:PMC4573668

Hu JX, Thomas CE, Brunak S. Network biology concepts in complex disease comorbidities. Nat Rev Genet. 2016; 17(10):615-629. https://doi.org/10.1038/nrg.2016.87 PMid:27498692

Ahn AC, Tewari M, Poon C-S, Phillips RS. The limits of reductionism in medicine: could systems biology offer an alternative? PLoS Med. 2006; 3(6):e208. https://doi.org/10.1371/journal.pmed.0030208 PMid:16681415 PMCid:PMC1459480

Cardinal-Fernà ndez P, Nin N, Ruiz-Cabello J, Lorente JA. Systems Medicine: a new approach to clinical practice. Arch Bronconeumol (English Ed). 2014; 50(10):444-451. https://doi.org/10.1016/j.arbr.2014.09.001

Apweiler R, Beissbarth T, Berthold MR, et al. Whither Systems Medicine? Exp Mol Med. 2018; 50(3):e453. https://doi.org/10.1038/emm.2017.290 PMid:29497170 PMCid:PMC5898894

Fiandaca MS, Mapstone M, Connors E, et al. Systems healthcare: a holistic paradigm for tomorrow. BMC Syst Biol. 2017; 11(1):1-17. https://doi.org/10.1186/s12918-017-0521-2 PMid:29258513 PMCid:PMC5738174

Goldman AW, Burmeister Y, Cesnulevicius K, et al. Bioregulatory Systems Medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity? Front Physiol. 2015; 6:225. https://doi.org/10.3389/fphys.2015.00225 PMid:26347656 PMCid:PMC4541032

Varela FJ, Maturana HR, Uribe RB. Autopoiesis: the organization of living systems, characterization and a model. Biosystems. 1974; 5:187-196. https://doi.org/10.1016/0303-2647(74)90031-8

Varela FJ, Shear J. First-person methodologies: what, why, how? Journal of Consciousness Studies. 1999; 6(2-3):1-14.

Barabà si A. Emergence of scaling in random networks. Science. 1999; 286(5439):509- 512. https://doi.org/10.1126/science.286.5439.509 PMid:10521342

Barabà si A-L, Gulbahce N, Loscalzo J. Network medicine: a network-based approach to human disease. Nat Rev Genet. 2011; 12(1):56-68. https://doi.org/10.1038/nrg2918 PMid:21164525 PMCid:PMC3140052

Uriarte SM, Rane MJ, Luerman GC, et al. Granule exocytosis contributes to priming and activation of the human neutrophil respiratory burst. J Immunol. 2011; 187(1):391-400. https://doi.org/10.4049/jimmunol.1003112 PMid:21642540 PMCid:PMC3582343

Whitacre JM. Biological robustness: paradigms, mechanisms, and systems principles. Front Genet. 2012; 3:67. https://doi.org/10.3389/fgene.2012.00067 PMid:22593762 PMCid:PMC3350086

Okuyama H, Langsjoen PH, Hamazaki T, et al. Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. Expert Rev Clin Pharmacol. 2015; 8(2):189-199. https://doi.org/10.1586/17512433.2015.1011125 PMid:25655639

Serhan CN, Levy BD. Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators. J Clin Invest. May 2018. https://doi.org/10.1172/JCI97943 PMid:29757195 PMCid:PMC6025982

Ricciotti E, FitzGerald GA. Prostaglandins and inflammation. Arterioscler Thromb Vase Biol. 2011; 31 (5):986-1000. https://doi.org/10.1161/ATVBAHA.110.207449 PMid:21508345 PMCid:PMC3081099

Dakin SG, Dudhia J, Smith RKW. Resolving an inflammatory concept: the importance of inflammation and resolution in tendinopathy. Vet Immunol Immunopathol. 2014; 158(3-4):121-127. https://doi.org/10.1016/j.vetimm.2014.01.007 PMid:24556326 PMCid:PMC3991845

Cesario A, Auffray C, Russo P, Hood L. P4 medicine needs P4 education. Curr Pharm Des. 2014; 20(38):6071-6072. https://doi.org/10.2174/1381612820666140314145445 PMid:24641231

van Bon L, Affandi AJ, Broen J, et al. Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med. 2014; 370(5):433-443. https://doi.org/10.1056/NEJMoa1114576 PMid:24350901 PMCid:PMC4040466

Buchman TG. The community of the self. Nature. 2002; 420(6912):246-251. https://doi.org/10.1038/nature01260 PMid:12432410

Buchman TG. Cardiovascular variability as a measure of inflammation. Crit Care Med. 2014; 42(8):1964. https://doi.org/10.1097/CCM.0000000000000460 PMid:25029145

Fuite J, Vernon SD, Broderick G. Neuroendocrine and immune network re-modeling in chronic fatigue syndrome: an exploratory analysis. Genomics. 2008; 92(6):393-399. https://doi.org/10.1016/j.ygeno.2008.08.008 PMid:18775774

Dobrota R, Mihai C, Distler O. Personalized medicine in systemic sclerosis: facts and promises. Curr Rheumatol Rep. 2014; 16(6):425. https://doi.org/10.1007/s11926-014-0425-8 PMid:24752884

Barko PC, McMichael MA, Swanson KS, Williams DA. The gastrointestinal microbiome: a review. J Vet Intern Med. 2018; 32(1):9-25. https://doi.org/10.1111/jvim.14875 PMid:29171095 PMCid:PMC5787212

Chrousos GP. Stress and disorders of the stress system. Nature reviews endocrinology. 2009; 5(7):374-381. https://doi.org/10.1038/nrendo.2009.106 PMid:19488073

Escher Bl, Hackermuller J, Polte T, et al. From the exposome to mechanistic understanding of chemical-induced adverse effects. Environ Int. 2017; 99:97-106. https://doi.org/10.1016/j.envint.2016.11.029 PMid:27939949 PMCid:PMC6116522

Miller GW, Jones DP. The nature of nurture: refining the definition of the exposome. Toxicol Sci. 2014; 137(1):1-2. https://doi.org/10.1093/toxsci/kft251 PMid:24213143 PMCid:PMC3871934

Nakamura J, Mutlu E, Sharma V, et al. The endogenous exposome. DNA Repair (Amst). 2014; 19:3-13. https://doi.org/10.1016/j.dnarep.2014.03.031 PMid:24767943 PMCid:PMC4097170

St Laurent G, Seilheimer B, Tackett M, et al. Deep sequencing transcriptome analysis of murine wound healing: effects of a multicomponent, multitarget natural product therapy-Tr14. Front Mol Biosci. 2017; 4(August):1-12. https://doi.org/10.3389/fmolb.2017.00057 PMid:28879183 PMCid:PMC5572416

Kitano H. Violations of robustness trade-offs. Mol Syst Biol. 2010; 6:384. https://doi.org/10.1038/msb.2010.40 PMid:20571533 PMCid:PMC2913402

Kitano H. Biological robustness in complex host-pathogen systems. Prog Drug Res. 2007; 64(239):239-263. https://doi.org/10.1007/978-3-7643-7567-6_10 PMid:17195478

Kotas ME, Medzhitov R. Homeostasis, inflammation and disease susceptibility. Cell. 2015; 160(5):816-827. https://doi.org/10.1016/j.cell.2015.02.010 PMid:25723161 PMCid:PMC4369762

Stearns SC, Medzhitov R. Evolutionary Medicine. Oxford, UK: Oxford University Press; 2016.

Cheng LE, Locksley RM. Allergic inflammation: innately homeostatic. Cold Spring Harb Perspect Biol. 2014; 7(3):a016352. https://doi.org/10.1101/cshperspect.a016352 PMid:25414367 PMCid:PMC4355269

Miyake K, Kaisho T. Homeostatic inflammation in innate immunity. Curr Opin Immunol. 2014; 30(10):85-90. https://doi.org/10.1016/j.coi.2014.08.003 PMid:25190609

Chovatiya R, Medzhitov R. Stress, inflammation, and defense of homeostasis. Mol Cell. 2014; 54(2):281-288. https://doi.org/10.1016/j.molcel.2014.03.030 PMid:24766892 PMCid:PMC4048989

St Laurent G, Toma I, Seilheimer B, et al. Differential effects of Tr14 versus diclofenac on COX/LOX pathways revealed by RNASeq. Ann Rheum Dis. 2018; 77(2):238-239. https://doi.org/10.1136/annrheumdis-2018-eular.3779

St Laurent G, Toma I, Tackett M, et al. Differential effects of Tr14 versus diclofenac on pro-resolving lipid mediators revealed by RNASeq. Ann Rheum Dis. 2018; 77(2):1237-1238. https://doi.org/10.1136/annrheumdis-2018-eular.3789

Ahn AC, Tewari M, Poon C-S, Phillips RS. The clinical applications of a systems approach. PLoS Med. 2006; 3(7):e209. https://doi.org/10.1371/journal.pmed.0030209 PMid:16683861 PMCid:PMC1459481

Marciniak A, Patro-Matysza J, Kimber-Trojnar Z, Marciniak B, Oleszczuk J, Leszczyhska-Gorzelak B. Fetal programming of the metabolic syndrome. Taiwan J Obstet Gynecol. 2017; 56(2): 133-138. https://doi.org/10.1016/j.tjog.2017.01.001 PMid:28420495

Perera F, Herbstman J. Prenatal environmental exposures, epigenetics, and disease. Reprod Toxicol. 2011; 31(3):363-373. https://doi.org/10.1016/j.reprotox.2010.12.055 PMid:21256208 PMCid:PMC3171169

Jiménez-Chillarón JC, Nijland MJ, Ascensà o AA, et al. Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling. Epigenetics. 2015; 10(4):259-273. https://doi.org/10.1080/15592294.2015.1020267 PMid:25774863 PMCid:PMC4622959

Sun K, Song J, Liu K, et al. Associations between homocysteine metabolism related SNPs and carotid intima-media thickness: a Chinese sib pair study. J Thromb Thrombolysis. 2017; 43(3):401-410. https://doi.org/10.1007/s11239-016-1449-x PMid:27822905 PMCid:PMC5337241

Thompson ER, Rowley SM, Li N, et al. Panel testing for familial breast cancer: calibrating the tension between research and clinical care. J Clin Oncol. 2016; 34(13):1455-1459. https://doi.org/10.1200/JCO.2015.63.7454 PMid:26786923

Monte AA, Brocker C, Nebert DW, Gonzalez FJ, Thompson DC, Vasiliou V. Improved drug therapy: triangulating phenomics with genomics and metabolomics. Hum Genomics. 2014; 8(1):1-9. https://doi.org/10.1186/s40246-014-0016-9 PMid:25181945 PMCid:PMC4445687

Navarro-López V, Ramirez-Boscà A, Ramón-Vidal D, et al. Effect of oral administration of a mixture of probiotic strains on SCORAD Index and use of topical steroids in young patients with moderate atopic dermatitis: a randomized clinical trial. JAMA Dermatol. 2018; 154(1):37-43. https://doi.org/10.1001/jamadermatol.2017.3647 PMid:29117309 PMCid:PMC5833582

Calabrese EJ. Hormesis: from mainstream to therapy. J Cell Commun Signal. 2014; 8(4):289-291. https://doi.org/10.1007/s12079-014-0255-5 PMid:25366126 PMCid:PMC4390802

Yun J, Finkel T. Mitohormesis. Cell Metab. 2014; 19(5):757-766. https://doi.org/10.1016/j.cmet.2014.01.011 PMid:24561260 PMCid:PMC4016106

Srivastava S. The mitochondrial basis of aging and age-related disorders. Genes (Basel). 2017; 8(12). https://doi.org/10.3390/genes8120398 PMid:29257072 PMCid:PMC5748716

Barbour JA, Turner N. Mitochondrial stress signaling promotes cellular adaptations. Int J Cell Biol. 2014; 2014. https://doi.org/10.1155/2014/156020 PMid:24587804 PMCid:PMC3920668

Kim S-A, Lee Y-M, Choi J-Y, Jacobs DR, Lee D-H. Evolutionarily adapted hormesisinducing stressors can be a practical solution to mitigate harmful effects of chronic exposure to low dose chemical mixtures. Environ Pollut. 2018; 233:725-734. https://doi.org/10.1016/j.envpol.2017.10.124 PMid:29126094

Keim AP, Slis JR, Mendez U, et al. The multicomponent medication Lymphomyosot improves the outcome of experimental lymphedema. Lymphat Res Biol. 2013; 11(2):81-92. https://doi.org/10.1089/lrb.2012.0024 PMid:23725444 PMCid:PMC3696932

van Ommen B, Wopereis S, van Empelen P, et al. From diabetes care to diabetes cure: the integration of systems biology, eHealth, and behavioral change. Front Endocrinol (Lausanne). 2018; 8:381. https://doi.org/10.3389/fendo.2017.00381 PMid:29403436 PMCid:PMC5786854

Stroeve JHM, van Wietmarschen H, Kremer BHA, van Ommen B, Wopereis S. Phenotypic flexibility as a measure of health: the optimal nutritional stress response test. Genes Nutr. 2015; 10(3):459. https://doi.org/10.1007/s12263-015-0459-1 PMid:25896408 PMCid:PMC4404421

Lozada C, del Rio E, Reitberg D, Smith R, Kahn C, Moskowitz RW. A multi-center double-blind, randomized, controlled trial (db-RCT) to evaluate the effectiveness and safety of co-administered Traumeel® (Tr14) and Zeel® (Ze14) intra-articular (IA) injections versus IA placebo in patients with moderate-to-severe pain ass. Arthritis Rheum. 2014; 66(Suppl):S1266. https://doi.org/10.1136/annrheumdis-2015-eular.4268

Lozada C, del Rio E, Reitberg DP, Smith R, Moskowitz RW. Risk-benefit of coadministered Traumeel® (Tr14) and Zeel® (Ze14) intra-articular (IA) injections in patients with moderate-to-severe pain associated with OA of the knee (OAK) (THU0441). Ann Rheum Dis. 2015; 74(2):4268. https://doi.org/10.1136/annrheumdis-2015-eular.4268

Lozada CJ, del Rio E, Reitberg DP, Smith RA, Kahn CB, Moskowitz RW. A doubleblind, randomized, saline-controlled study of the efficacy and safety of co-administered intra-articular injections of Tr14 and Ze14 for treatment of painful osteoarthritis of the knee: the MOZArT trial. Eur J Integr Med. 2017; 13:54-63. https://doi.org/10.1016/j.eujim.2017.07.005

doi: 10.101 6/j.eujim.201 7.07.005.

Langevin HM. Connective tissue: a body-wide signaling network? Med Hypotheses. 2006; 66(6):1074-1077. https://doi.org/10.1016/j.mehy.2005.12.032 PMid:16483726

Oschman JL. Charge transfer in the living matrix. J Bodyw Mov Ther. 2009; 13(3):215-228. https://doi.org/10.1016/j.jbmt.2008.06.005 PMid:19524846

Benias PC, Wells RG, Sackey-Aboagye B, et al. Structure and distribution of an unrecognized interstitium in human tissues. Sci Rep. 2018; 8(1):1-8. https://doi.org/10.1038/s41598-018-23062-6 PMid:29588511 PMCid:PMC5869738

Langevin HM, Yandow J a. Relationship of acupuncture points and meridians to connective tissue planes. Anat Rec. 2002; 269(6):257-265. https://doi.org/10.1002/ar.10185 PMid:12467083

Kersschot J. Biopuncture: The Management of Common Orthopedic and Sports Disorders. Thieme; 2014 May 14.

Frase W, Bauer G. Moderne Homöosiniatrie. Baden-Baden, Germany: Aurelia, 2002.

Ben-Yakir S. Primary evaluation of homeopathic remedies injected via acupuncture points to reduce chronic high somatic cell counts in modern dairy farms. J Biomed Ther. 2004; (Fall):13-15.

Bossy J. Morphological data concerning the acupuncture points and channel network. Acupuncture & electro-therapeutics research. 1984; 9(2):79-106. https://doi.org/10.3727/036012984816714758 PMid:6148847

Bredikhin A V, Bredikhin KA, Chekha OA. New organ representation areas localized between front & back of the human neck and body their potential application to metameric acupuncture. Acupunct Electrother Res. 2016; 41(3-4):199-205. https://doi.org/10.3727/036012917X14831065080050

Roccia MG, Fioranelli M, Lotti T. Dermatol Ther. Obesity, psoriasis, and microbiota: an unexplored dangerous connection? J Biol Regul Homeost Agents. 2015. https://doi.org/10.1111/dth.12218 PMid:25731602

França K, Castillo DE, Roccia MG, Lotti T, Wollina U, Fioranelli M. Psychoneurocutaneous medicine: past, present and future. Wien Med Wochenschr. 2017. https://doi.org/10.1007/s10354-017-0573-3 PMid:28616665

Fioranelli M, Del Prete M, Aracena JC, Roccia MG, Dal Lin C, Tomella C. Integrative Cardiology. Editor: Massimo Fioranelli. Low-Dose Therapy for the Treatment of Low-Grade Chronic Inflammation. Springer International Switzerland, 2017. https://doi.org/10.1007/978-3-319-40010-5_3 PMid:28801812

Fioranelli M, Roccia MG, Lotti T. Coronary blood flow and psoriasis. Dermatol Ther. 2017. https://doi.org/10.1111/dth.12471 PMid:28211598

Published
2019-09-14
How to Cite
1.
Fioranelli M, Sepehri A, Roccia MG, Linda C, Rossi C, Dawodo A, Vojvodic P, Lotti J, Barygina V, Vojvodic A, Wollina U, Tirant M, Van TN, Lotti T. Clinical Applications of System Regulation Medicine. Open Access Maced J Med Sci [Internet]. 2019Sep.14 [cited 2020Oct.26];7(18):3053-60. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2019.775

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