The Effects of Magnesium â€“ Melatonin - Vit B Complex Supplementation in Treatment of Insomnia
Insomnia means difficulty in falling asleep and/or stays asleep. Insomnia commonly leads to daytime sleepiness, lethargy, and a general feeling of being unwell. The most common treatment of insomnia includes GABAA receptor positive allosteric modulators or Melatonin agonists. Our study aimed to evaluate the efficacy of Magnesium- melatonin-vitamin B complex supplement in the treatment of insomnia. The study included 60 patients diagnosed with insomnia. The patients were randomly divided into study group (N = 30), and control group (N = 30), and study group was treated with Magnesium-melatonin-vitamin B complex (one dose contains 175 mg liposomal magnesium oxide, 10 mg Vit B6, 16 Î¼g vit B12, melatonin 1 mg, Extrafolate-S 600 Î¼g) once a day 1 hour before sleep, during the 3 months. The severity of insomnia symptoms was measured by self-reported Athens insomnia scale (AIS), with a cut-off score by Soldatos (AIS score â‰¥ 6). Mean AIS score at zero points was 14,93 Â± 3,778 in the study group and 14,37 Â± 4,081 in the control group (p = 0,476), indicating the compatibility of the groups, and both scores correspond to mild to moderate insomnia. Mean AIS score after 3 months of the Magnesium- melatonin- vitamin B complex supplementation was 10,50 Â± 4,21 corresponding to mild insomnia, while median AIS score in the control group was 15,13 Â± 3,76 which is referred to moderate insomnia, and difference among groups was significant (p = 0,000). Our foundingâ€™s indicating that 3 months of the Magnesium- melatonin-vitamin B complex supplementation has a beneficial effect in the treatment of insomnia regardless of cause.
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Healthline Editorial Team, Lamoreux K. Everything You Need to Know About Insomnia, 2018. Available from: https://www.healthline.com/health/insomnia. Last accessed 26 Nov 2018.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Arlington, VA: American Psychiatric Association Publishing, 2013. https://doi.org/10.1176/appi.books.9780890425596
Zohar J, Stahl S, Moller HJ, Blier P, Kupfer D, Yamawaki S, Ucheida S, Draggo F, Goodwin G, Nutt D. Neuroscience based Nomenclature- the second edition, 2018. Available from: http://www.nbn2.com/ (Last accessed 27 Nov 2018).
Breus M. Understanding Melatonin: How Melatonin Can Help Sleep and Bio Time, 2018. Available from: https://www.thesleepdoctor.com/2017/06/06/understanding-melatonin-melatonin-can-help-sleep-bio-time/ (Last accessed 27 Nov 2018).
Grima NA, Rajaratnam SMW, Mansfield D, Sletten TL, Spitz G, Ponsford JL. Efficacy of melatonin for sleep disturbance following traumatic brain injury: a randomised controlled trial. BMC Med. 2018; 16(1):8. https://doi.org/10.1186/s12916-017-0995-1 PMid:29347988 PMCid:PMC5774131
Alzoubi, KH, Mayyas FA, Khabour OF, Bani Salama FM, Alhashimi FH, Mhaidat NM. Chronic Melatonin Treatment Prevents Memory Impairment Induced by Chronic Sleep Deprivation. Molecular Neurobiology. 2016; 53(5):3439-3447. https://doi.org/10.1007/s12035-015-9286-z PMid:26084441
Sochan J. Top 2 sleep promoting nutritients: Magnesium and Calcium, 2018. Available from: https://www.naturimedica.com/top-2-sleep-promoting-nutrients-magnesium-and-calcium/ (Last accessed 27 Nov 2018).
Abbasi B, Kimiagar M, Sadeqhniiat K, Shirazi MM, Hedavati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res med Sci. 2012; 17(12):1161-9.
Cao Y, Zhen S, Taylor AW, Appleton S, Atlantis E, Shi Z. Magnesium Intake and Sleep Disorder Symptoms: Findings from the Jiangsu Nutrition Study of Chinese Adults at Five-Year Follow-Up. Nutritients. 2018; 21(10):E1354. https://doi.org/10.3390/nu10101354 PMid:30248967 PMCid:PMC6212970
Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017; 9(5):429. https://doi.org/10.3390/nu9050429 PMid:28445426 PMCid:PMC5452159
Tarleton EK, Littenberg B, Maclean CD, Kennedy AG, Daley C. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. PLoS One. 2017; 12(6):e0180067. https://doi.org/10.1371/journal.pone.0180067 PMid:28654669 PMCid:PMC5487054
Li L, Wu C, Gan Y, Qu X, Lu Z. Insomnia and the risk of depression: a meta-analysis of prospective cohort studies. BMC Psychiatry. 2016; 16:375. https://doi.org/10.1186/s12888-016-1075-3 PMid:27816065 PMCid:PMC5097837
Comai S, Gobbi G. CCNP Award Paper: Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology. J Psychiatry Neurosci. 2014; 39(1):6-21. https://doi.org/10.1503/jpn.130009 PMid:23971978 PMCid:PMC3868666
Garfinkel D, Zisapel N, Wainstein J, et al. Facilitation of benzodiazepine discontinuation by melatonin: a new clinical approach. Arch Intern Med. 1999; 159:2456-60. https://doi.org/10.1001/archinte.159.20.2456 PMid:10665894
Sumaya IC, Masana MI, Dubocovich ML. The antidepressant-like effect of the melatonin receptor ligand luzindole in mice during forced swimming requires expression of MT2 but not MT1 melatonin receptors. J Pineal Res. 2005; 39:170-7. https://doi.org/10.1111/j.1600-079X.2005.00233.x PMid:16098095
Hickie IB, Rogers NL. Novel melatonin-based therapies: potential advances in the treatment of major depression. Lancet. 2011; 378:621-31. https://doi.org/10.1016/S0140-6736(11)60095-0
Xiaopeng J, Grander MA, Liu J. The relationship between micronutrient status and sleep patterns: a systematic review. Public Health Nutr. 2017; 20(4):687-701. https://doi.org/10.1017/S1368980016002603 PMid:27702409 PMCid:PMC5675071
Lichstein KL, Payne KL, Soeffing JP, Durrence HH, Taylor DJ, Riedel BW, Bush AJ. Vitamins and sleep: An exploration study. Sleep Med. 2008; 9(1):27-32. https://doi.org/10.1016/j.sleep.2006.12.009 PMid:17825610 PMCid:PMC2174691
Syed EU, Wasay M, Awan S. Vitamin B12 Supplementation in Treating Major Depressive Disorder: A Randomized Controlled Trial. Open Neurol J. 2013; 7:44-48. https://doi.org/10.2174/1874205X01307010044 PMid:24339839 PMCid:PMC3856388
Williams AI, Cotter A, Sabina A, Girard C, Goodman J, Katz DL. The role of vitamin B6 as treatment for depression: a systematic review. Family Practice. 2005; 22(5):532-37. https://doi.org/10.1093/fampra/cmi040 PMid:15964874
Ochoa-Sanchez R, Rainer Q, Comai S, et al. Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam. Prog neuropsychopharmacol BiolPsychiatry. 2012; 39:318-25. https://doi.org/10.1016/j.pnpbp.2012.07.003 PMid:22789661
Rondanelli M, Opizzi A, Monteferrario F, Antoniella N, Manni R, Klersy C. The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial. J Am Geriatr Soc. 2011; 59:82-90. https://doi.org/10.1111/j.1532-5415.2010.03232.x PMid:21226679
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