Unilateral Pseudo-Ainhum in Liver Cirrhosis

  • Uwe Wollina Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital, Dresden, Germany
  • Michael Tirant Department of Dermatology, University of Rome “G. Marconi”, Rome, Italy
  • Aleksandra Vojvodic Military Medical Academy of Belgrade, Belgrade, Serbia
  • Veronica di Nardo Department of Dermatology, University of Rome “G. Marconi”, Rome, Italy
  • Torello Lotti Department of Dermatology, University of Rome “G. Marconi”, Rome, Italy; Hanoi Medical University, Hanoi, Vietnam
Keywords: Pseudo-ainhum, Ainhum, Liver Cirrhosis, Fibrosis


BACKGROUND: Pseudo-ainhum is defined as any case of autoâ€amputation not associated with the classic spontaneous ainhum seen in Africans with unknown etiology.

CASE PRESENTATION: A severely ill 58-year-old male patient presented with a painless constricting circular band on his left second toe. His medical history was remarkable for severe alcoholic liver cirrhosis with ascites formation leading to dyspnea. He had a hypoalbuminemia and a pronounced peripheral sensory neuropathy.

CONCLUSION: Here we present the second case of pseudo-ainhum associated with liver cirrhosis.


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Romanelli RG, Stasi C. Recent advancements in diagnosis and therapy of liver cirrhosis. Curr Drug Targets. 2016; 17(15):1804-1817. https://doi.org/10.2174/1389450117666160613101413 PMid:27296314

Sanglodkar U, Jain M, Jothimoni D, Parida S, G B, Venkataraman J. Cellulitis in liver cirrhosis - a series of 25 cases from southern India. Clin Exp Hepatol. 2018; 4(3):201-204. https://doi.org/10.5114/ceh.2018.78125 PMid:30324146 PMCid:PMC6185931

Chiba T, Hayashi F, Shinmura M, Kiyomatsu M, Tatematsu S, Nakao M, Furue M. Yellow urticaria in a patient with hepatic cirrhosis. G Ital Dermatol Venereol. 2014; 149(3):381-2.

Dogra S, Jindal R. Cutaneous manifestations of common liver diseases. J Clin Exp Hepatol. 2011; 1(3):177-84. https://doi.org/10.1016/S0973-6883(11)60235-1

Muehrcke RC. The finger-nails in chronic hypoalbuminaemia; a new physical sign. Br Med J. 1956; 1(4979):1327-8. https://doi.org/10.1136/bmj.1.4979.1327 PMid:13316143 PMCid:PMC1980060

Wollina U, Graefe T, Oelzner P, Hein G, Schreiber G. Pseudoainhum of all fingers associated with Reynolds' syndrome and breast cancer: report of a case and review of the literature. J Am Acad Dermatol. 2001; 44(2 Suppl):381-4. https://doi.org/10.1067/mjd.2001.104971 PMid:11174422

Daccarett M, Espinosa G, Rahimi F, Eckerman CM, Wayne-Bruton S, Couture M, Rosenblum J. Ainhum (dactylolysis spontanea): a radiological survey of 6000 patients. J Foot Ankle Surg. 2002; 41(6):372-8. https://doi.org/10.1016/S1067-2516(02)80083-7

Rashid RM, Cowan E, Abbasi SA, Brieva J, Alam M. Destructive deformation of the digits with auto-amputation: a review of pseudo-ainhum. J Eur Acad Dermatol Venereol. 2007; 21(6):732-7. https://doi.org/10.1111/j.1468-3083.2007.02224.x PMid:17567298

Piccolo V, Corneli P, Piccolo S, Zalaudek I, Argenziano G, Russo T. Pseudo ainhum and facial malformation secondary to Streeter's dysplasia. J Eur Acad Dermatol Venereol. 2019. https://doi.org/10.1111/jdv.15757 PMid:31222806

Bassetto F, Tiengo C, Sferrazza R, Belloni-Fortina A, Alaibac M. Vohwinkel syndrome: treatment of pseudo-ainhum. Int J Dermatol. 2010; 49(1):79-82. https://doi.org/10.1111/j.1365-4632.2009.04267.x PMid:20465619

Behera B, Gochhait D, Thappa DM. Pseudoainhum and autoamputation associated with lamellar ichthyosis. Indian J Dermatol Venereol Leprol. 2017; 83(6):728-729. https://doi.org/10.4103/ijdvl.IJDVL_56_17 PMid:28936990

Silva M, Ribeiro R, Oliveira J. Pseudoainhum in systemic sclerosis. J Rheumatol. 2016; 43(11): 2076. https://doi.org/10.3899/jrheum.160239 PMid:27803345

Dasari BV, McBrearty A, Lau L, Lee B. Pseudoainhum of the toe with underlying chronic lower-limb ischemia. Int J Low Extrem Wounds. 2011; 10(2):96-7. https://doi.org/10.1177/1534734611409369 PMid:21693445

Richey PM, Stone MS. Resolution of pseudoainhum with acitretin therapy in a patient with palmoplantar keratoderma and congenital alopecia. JAAD Case Rep. 2019; 5(3):219-221. https://doi.org/10.1016/j.jdcr.2018.12.004 PMid:30809564 PMCid:PMC6374960

Pisoh T, Bhatia A, Oberlin C. Surgical correction of pseudo-ainhum in Vohwinkel syndrome. J Hand Surg Br. 1995; 20(3):338-41. https://doi.org/10.1016/S0266-7681(05)80090-7

Zamiri M, Watson S. Loricrin palmoplantar keratoderma: full-thickness skin grafting for pseudoainhum. Clin Exp Dermatol. 2019; 44(4):444-446. https://doi.org/10.1111/ced.13770 PMid:30264492

How to Cite
Wollina U, Tirant M, Vojvodic A, di Nardo V, Lotti T. Unilateral Pseudo-Ainhum in Liver Cirrhosis. Open Access Maced J Med Sci [Internet]. 2019Sep.10 [cited 2021Jan.24];7(18):3013-4. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2019.681

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