Immunocompromised Districts of Skin: A Case Series and a Literature Review

  • Aleksandra Vojvodic Department of Dermatology and Venereology, Military Medical Academy of Belgrade, Belgrade, Serbia
  • Michael Tirant Department of Dermatology, University of Rome “G. Marconi”, Rome, Italy; Hanoi Medical University, Hanoi, Vietnam
  • Veronica di Nardo Department of Dermatology, University of Rome “G. Marconi”, Rome, Italy
  • Torello Lotti Department of Dermatology, University of Rome “G. Marconi”, Rome, Italy
  • Uwe Wollina Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital, Dresden, Germany
Keywords: Koebner phenomenon; Wolf's isotopic response, Immunocompromised districts of skin


BACKGROUND: The concept of immunocompromised districts of skin has been developed by Ruocco and helps to explain certain aspects of the macromorphology of skin diseases. This concept unites the isomorphic response of Koebner and the isotopic response of Wolf.

CASE REPORTS: We present different cutaneous conditions which can lead to immunocompromised districts of skin such as scars, radiodermatitis, lymphedema, disturbed innervation or mechanical friction etc. Typical and rarer skin disorders associated with them are discussed and illustrated by their observations.

CONCLUSION: At this moment, we wish to inform dermatologists and non-dermatologists about Ruocco’s concept and its implications.



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How to Cite
Vojvodic A, Tirant M, di Nardo V, Lotti T, Wollina U. Immunocompromised Districts of Skin: A Case Series and a Literature Review. Open Access Maced J Med Sci [Internet]. 2019Sep.10 [cited 2020Oct.26];7(18):2969-75. Available from:

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