Giant Squamous Cell Carcinoma on Chronic Lichen Planus on the Ankle - A Case Report and Short Literature Review

  • Uwe Wollina Academic Teaching Hospital DresdenDepartment of Dermatology and Allergology
  • Claudia Krönert Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital
  • Jacqueline Schönlebe Institute of Pathology “Georg Schmorl”, Städtisches Klinikum Dresden, Academic Teaching Hospital
  • Aleksandra Vojvodic Military Medical Academy of Belgrade, Serbia, and University of Rome Guglielmo Marconi Rome, Italy
  • Torello Lotti Department of Dermatology, University of Rome Guglielmo Marconi Rome, Italy
Keywords: Squamous cell carcinoma, Lichen planus, Malignant transformation, Surgery, Sepsis

Abstract

BACKGROUND: Cutaneous squamous cell carcinoma (SCC) is the second most common malignancy of skin. Although a major risk factor is a chronic exposure to ultraviolet radiation, preexistent chronic inflammatory disorders may also possess an increased risk for SCC. That is not the case for cutaneous lichen planus in contrast to oral lichen planus and oral SCC. 

CASE REPORT: We report the case of an 87-year-old Caucasian woman presenting with a giant verrucous tumour on the left ankle. She suffered from long-standing disseminated lichen planus. Histology confirmed the diagnosis of SCC on partly verrucous lichen planus. The course was complicated due to sepsis. An emergency transfemoral amputation became necessary. The patients survived and could be released into her nursery. A literature review underlined the rarity of SCC on lichen planus of the skin. Most of these rare cases were in patients in their second half of life on the lower legs. Hypertrophic lichen plnaus was overrepresented.  

CONCLUSIONS: Although very rare by number, SCC can complicate lichen planus and lead to the life-threatening situation. Atypical verrucous lesions on lichen planus warrant a histologic analysis. Surgery is the treatment of choice for cutaneous SCC.

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Author Biographies

Uwe Wollina, Academic Teaching Hospital DresdenDepartment of Dermatology and Allergology

Head of Department of Dermatology and Allergology

Claudia Krönert, Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital

Senior Advisor

Jacqueline Schönlebe, Institute of Pathology “Georg Schmorl”, Städtisches Klinikum Dresden, Academic Teaching Hospital

Senior Advisor

Aleksandra Vojvodic, Military Medical Academy of Belgrade, Serbia, and University of Rome Guglielmo Marconi Rome, Italy

Professor of Dermatology

Torello Lotti, Department of Dermatology, University of Rome Guglielmo Marconi Rome, Italy

Professor of Dermatology

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Published
2019-08-19
How to Cite
1.
Wollina U, Krönert C, Schönlebe J, Vojvodic A, Lotti T. Giant Squamous Cell Carcinoma on Chronic Lichen Planus on the Ankle - A Case Report and Short Literature Review. Open Access Maced J Med Sci [Internet]. 2019Aug.19 [cited 2020Oct.26];7(18):3061-3. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2019.553

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