Treatment of Psoriasis: Novel Approaches to Topical Delivery

  • Uwe Wollina Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital, Dresden, Germany
  • Michael Tirant Department of Dermatology, University of Rome “G. Marconi”, Rome, Italy
  • Aleksandra Vojvodic Military Medical Academy of Belgrade, Belgrade, Serbia
  • Torello Lotti Department of Dermatology, University of Rome “G. Marconi”, Rome, Italy
Keywords: Topical drug therapy, Psoriasis, Nanoparticles, Laser-assisted drug delivery, Foams, Niosomes, Ethosomes

Abstract

Topical treatment is the cornerstone for the management of mild to moderate psoriasis. Despite efforts in drug development, patient's satisfaction with the available topical treatments is limited. A strategy to improve safety, efficacy and comfort of topical treatment provides the development of new drug delivery and drug carrier systems. This review provides an overview of recent advances in this field with a focus on psoriasis. Laser-assisted drug delivery, foam formulations, nanoparticles, ethosomes, and niomes are considered. Hopefully, these new developments will improve topical drug therapy and patient satisfaction.

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References

Choy YB, Prausnitz MR. The rule of five for non-oral routes of drug delivery: ophthalmic, inhalation and transdermal. Pharm Res. 2011; 28(5):943-8. https://doi.org/10.1007/s11095-010-0292-6 PMid:20967491 PMCid:PMC3074025

Wollina U. Psoriasis. In: França K, Lotti T (eds) Advances in Integrative Dermatology. 1st Edition. Chichester, UK: John Wiley & Sons, Ltd, 2019:131-144. https://doi.org/10.1002/9781119476009.ch10

Florek AG, Wang CJ, Armstrong AW. Treatment preferences and treatment satisfaction among psoriasis patients: a systematic review. Arch Dermatol Res. 2018; 310(4):271-319. https://doi.org/10.1007/s00403-018-1808-x PMid:29442137

Telekes A, Hegedűs M, Kiss I. Therapeutic drug monitoring and measurement of drug concentrations using mass spectrometry. In: Vékey K, Telekes A, Vertes A (eds) Medical Applications of Mass Spectrometry. Elsevier, 2008:263-89. https://doi.org/10.1016/B978-044451980-1.50015-X

Lurie DJ, Mäder K. Monitoring drug delivery processes by EPR and related techniques--principles and applications. Adv Drug Deliv Rev. 2005; 57(8):1171-90. https://doi.org/10.1016/j.addr.2005.01.023 PMid:15935868

Hamishehkar H, Rahimpour Y, Kouhsoltani M. Niosomes as a propitious carrier for topical drug delivery. Expert Opin Drug Deliv. 2013; 10(2):261-72. https://doi.org/10.1517/17425247.2013.746310 PMid:23252629

Hsiao CY, Yang SC, Alalaiwe A, Fang JY. Laser ablation and topical drug delivery: a review of recent advances. Expert Opin Drug Deliv. 2019:1-16. https://doi.org/10.1080/17425247.2019.1649655 PMid:31389261

Bangert CA, Costner MI. Methotrexate in dermatology. Dermatol Ther. 2007; 20(4):216-28. https://doi.org/10.1111/j.1529-8019.2007.00135.x PMid:17970887

Wollina U, Ständer K, Barta U. Toxicity of methotrexate treatment in psoriasis and psoriatic arthritis--short- and long-term toxicity in 104 patients. Clin Rheumatol. 2001; 20(6):406-10. https://doi.org/10.1007/s100670170004 PMid:11771523

Taudorf EH. Laser-assisted delivery of topical methotrexate - in vitro investigations. Dan Med J. 2016; 63(6).

Nguyen HX, Banga AK. Effect of ablative laser on in vitro transungual delivery. Int J Pharm. 2018; 544(2):402-414. https://doi.org/10.1016/j.ijpharm.2017.09.048 PMid:28951347

Ramez SA, Soliman MM, Fadel M, Nour El-Deen F, Nasr M, Youness ER, Aboel-Fadl DM. Novel methotrexate soft nanocarrier/fractional erbium YAG laser combination for clinical treatment of plaque psoriasis. Artif Cells Nanomed Biotechnol. 2018; 46(sup1):996-1002. https://doi.org/10.1080/21691401.2018.1440236 PMid:29448838

Tamarkin D. Chapter 9. Foam: a unique delivery vehicle for topically applied formulations. In: Dayan N (editor). Handbook of formulating dermal applications: a definitive practical guide. Beverly, MA: Scrivener Publishing, 2017:233-60. https://doi.org/10.1002/9781119364221.ch9

Gold LS, Lebwohl M, Menter A, Villumsen J, Rosen M, Koo J. Aerosol Foam Formulation of Fixed Combination Calcipotriene Plus Betamethasone Dipropionate is Highly Efficacious in Patients With Psoriasis Vulgaris: Pooled Data From Three Randomized Controlled Studies. J Drugs Dermatol. 2016; 15(8):951-7.

Bewley AP, Shear NH, Calzavara-Pinton PG, Hansen JB, Nyeland ME, Signorovitch J. Calcipotriol plus betamethasone dipropionate aerosol foam vs. apremilast, methotrexate, acitretin or fumaric acid esters for the treatment of plaque psoriasis: a matching-adjusted indirect comparison. J Eur Acad Dermatol Venereol. 2019; 33(6):1107-15. https://doi.org/10.1111/jdv.15369 PMid:30472749 PMCid:PMC6766948

Nardo VD, Gianfaldoni S, Tchernev G, Wollina U, Barygina V, Lotti J, Daaboul F, Lotti T. Use of Curcumin in Psoriasis. Open Access Maced J Med Sci. 2018; 6(1):218-20. https://doi.org/10.3889/oamjms.2018.055 PMid:29484027 PMCid:PMC5816303

Kang NW, Kim MH, Sohn SY, Kim KT, Park JH, Lee SY, Lee JY, Kim DD. Curcumin-loaded lipid-hybridized cellulose nanofiber film ameliorates imiquimod-induced psoriasis-like dermatitis in mice. Biomaterials. 2018; 182:245-58. https://doi.org/10.1016/j.biomaterials.2018.08.030 PMid:30142524

Goyal R, Macri LK, Kaplan HM, Kohn J. Nanoparticles and nanofibers for topical drug delivery. J Control Release. 2016; 240:77-92. https://doi.org/10.1016/j.jconrel.2015.10.049 PMid:26518723 PMCid:PMC4896846

Sangeetha NM, Maitra U. Supramolecular gels: functions and uses. Chem Soc Rev. 2005; 34(10):821-36. https://doi.org/10.1039/b417081b PMid:16172672

Sun L, Liu Z, Wang L, Cun D, Tong HHY, Yan R, Chen X, Wang R, Zheng Y. Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel. J Control Release. 2017; 254:44-54. https://doi.org/10.1016/j.jconrel.2017.03.385 PMid:28344018

Mao KL, Fan ZL, Yuan JD, Chen PP, Yang JJ, Xu J, ZhuGe DL, Jin BH, Zhu QY, Shen BX, Sohawon Y, Zhao YZ, Xu HL. Skin-penetrating polymeric nanoparticles incorporated in silk fibroin hydrogel for topical delivery of curcumin to improve its therapeutic effect on psoriasis mouse model. Colloids Surf B Biointerfaces. 2017; 160:704-14. https://doi.org/10.1016/j.colsurfb.2017.10.029 PMid:29035818

de Lima Fontes M, Meneguin AB, Tercjak A, Gutierrez J, Cury BSF, Dos Santos AM, Ribeiro SJL, Barud HS. Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release properties. Carbohydr Polym. 2018; 179:126-34. https://doi.org/10.1016/j.carbpol.2017.09.061 PMid:29111035

Panonnummal R, Sabitha M. Anti-psoriatic and toxicity evaluation of methotrexate loaded chitin nanogel in imiquimod induced mice model. Int J Biol Macromol. 2018; 110:245-58. https://doi.org/10.1016/j.ijbiomac.2017.10.112 PMid:29054520

Ghate VM, Kodoth AK, Shah A, Vishalakshi B, Lewis SA. Colloidal nanostructured lipid carriers of pentoxifylline produced by microwave irradiation ameliorates imiquimod-induced psoriasis in mice. Colloids Surf B Biointerfaces. 2019; 181:389-99. https://doi.org/10.1016/j.colsurfb.2019.05.074 PMid:31170645

Kaur N, Sharma K, Bedi N. Topical Nanostructured Lipid Carrier Based Hydrogel of Mometasone Furoate for the Treatment of Psoriasis. Pharm Nanotechnol. 2018; 6(2):133-43. https://doi.org/10.2174/2211738506666180523112513 PMid:29788899

Meazza L, Foster JA, Fucke K, Metrangolo P, Resnati G, Steed JW. Halogen-bonding-triggered supramolecular gel formation. Nat Chem. 2013; 5(1):42-7. https://doi.org/10.1038/nchem.1496 PMid:23247176

Casal-Dujat L, Griffiths PC, Rodríguez-Abreu C, Solans C, Rogerse S, Pérez-García L. Nanocarriers from dicationic bis-imidazolium amphiphiles and their interaction with anionic drugs. J Mater Chem B 2013; 38(1):4963-71. https://doi.org/10.1039/c3tb20289e

Limón D, Jiménez-Newman C, Rodrigues M, González-Campo A, Amabilino DB, Calpena AC, Pérez-García L. Cationic Supramolecular Hydrogels for Overcoming the Skin Barrier in Drug Delivery. ChemistryOpen. 2017; 6(4):585-98. https://doi.org/10.1002/open.201700040 PMid:28794954 PMCid:PMC5542755

Limón D, Talló Domínguez K, Garduño-Ramírez ML, Andrade B, Calpena AC, Pérez-García L. Nanostructured supramolecular hydrogels: Towards the topical treatment of Psoriasis and other skin diseases. Colloids Surf B Biointerfaces. 2019; 181:657-70. https://doi.org/10.1016/j.colsurfb.2019.06.018 PMid:31212138

Capezzera R, Sala R, Venturini M, Zane C, Calzavara-Pinton P. PUVA photochemotherapy: update 2003. G Ital Dermatol Venereol. 2004; 139(2):111-30.

Oliveira CA, Gouvêa MM, Antunes GR, Freitas ZMF, Marques FFC, Ricci-Junior E. Nanoemulsion containing 8-methoxypsoralen for topical treatment of dermatoses: Development, characterization and ex vivo permeation in porcine skin. Int J Pharm. 2018; 547(1-2):1-9. https://doi.org/10.1016/j.ijpharm.2018.05.053 PMid:29800737

Barradas TN, Senna JP, Cardoso SA, de Holanda E Silva KG, Elias Mansur CR. Formulation characterization and in vitro drug release of hydrogel-thickened nanoemulsions for topical delivery of 8-methoxypsoralen. Mater Sci Eng C Mater Biol Appl. 2018; 92:245-253. https://doi.org/10.1016/j.msec.2018.06.049 PMid:30184748

Torsekar R, Gautam MM. Topical Therapies in Psoriasis. Indian Dermatol Online J. 2017; 8(4):235-245. https://doi.org/10.4103/2229-5178.209622 PMid:28761838 PMCid:PMC5518573

Tripathi PK, Gorain B, Choudhury H, Srivastava A, Kesharwani P. Dendrimer entrapped microsponge gel of dithranol for effective topical treatment. Heliyon. 2019; 5(3):e01343. https://doi.org/10.1016/j.heliyon.2019.e01343 PMid:30957038 PMCid:PMC6431737

Sathe P, Saka R, Kommineni N, Raza K, Khan W. Dithranol-loaded nanostructured lipid carrier-based gel ameliorate psoriasis in imiquimod-induced mice psoriatic plaque model. Drug Dev Ind Pharm. 2019; 45(5):826-838. https://doi.org/10.1080/03639045.2019.1576722 PMid:30764674

Colombo MD, Cassano N, Bellia G, Vena GA. Cyclosporine regimens in plaque psoriasis: an overview with special emphasis on dose, duration, and old and new treatment approaches. ScientificWorldJournal. 2013; 2013:805705. https://doi.org/10.1155/2013/805705 PMid:23983647 PMCid:PMC3745987

Walunj M, Doppalapudi S, Bulbake U, Khan W. Preparation, characterization, and in vivo evaluation of cyclosporine cationic liposomes for the treatment of psoriasis. J Liposome Res. 2019:1-12. https://doi.org/10.1080/08982104.2019.1593449 PMid:30897993

Benigni M, Pescina S, Grimaudo MA, Padula C, Santi P, Nicoli S. Development of microemulsions of suitable viscosity for cyclosporine skin delivery. Int J Pharm. 2018; 545(1-2):197-205. https://doi.org/10.1016/j.ijpharm.2018.04.049 PMid:29698819

Lapteva M, Santer V, Mondon K, Patmanidis I, Chiriano G, Scapozza L, Gurny R, Möller M, Kalia YN. Targeted cutaneous delivery of ciclosporin A using micellar nanocarriers and the possible role of inter-cluster regions as molecular transport pathways. J Control Release. 2014; 196:9-18. https://doi.org/10.1016/j.jconrel.2014.09.021 PMid:25278258

Wollina U. The role of topical calcineurin inhibitors for skin diseases other than atopic dermatitis. Am J Clin Dermatol. 2007; 8(3):157-73. https://doi.org/10.2165/00128071-200708030-00003 PMid:17492844

Lapteva M, Mondon K, Möller M, Gurny R, Kalia YN. Polymeric micelle nanocarriers for the cutaneous delivery of tacrolimus: a targeted approach for the treatment of psoriasis. Mol Pharm. 2014; 11(9):2989-3001. https://doi.org/10.1021/mp400639e PMid:25057896

Wan T, Pan W, Long Y, Yu K, Liu S, Ruan W, Pan J, Qin M, Wu C, Xu Y. Effects of nanoparticles with hydrotropic nicotinamide on tacrolimus: permeability through psoriatic skin and antipsoriatic and antiproliferative activities. Int J Nanomedicine. 2017; 12:1485-1497. https://doi.org/10.2147/IJN.S126210 PMid:28260894 PMCid:PMC5328661

Yu K, Wang Y, Wan T, Zhai Y, Cao S, Ruan W, Wu C, Xu Y. Tacrolimus nanoparticles based on chitosan combined with nicotinamide: enhancing percutaneous delivery and treatment efficacy for atopic dermatitis and reducing dose. Int J Nanomedicine. 2017; 13:129-142. https://doi.org/10.2147/IJN.S150319 PMid:29317821 PMCid:PMC5743175

Woolacott N, Hawkins N, Mason A, Kainth A, Khadjesari Z, Vergel YB, Misso K, Light K, Chalmers R, Sculpher M, Riemsma R. Etanercept and efalizumab for the treatment of psoriasis: a systematic review. Health Technol Assess. 2006; 10(46):1-233, i-iv. https://doi.org/10.3310/hta10460

Giulbudagian M, Yealland G, Hönzke S, Edlich A, Geisendörfer B, Kleuser B, Hedtrich S, Calderón M. Breaking the Barrier - Potent Anti-Inflammatory Activity following Efficient Topical Delivery of Etanercept using Thermoresponsive Nanogels. Theranostics. 2018; 8(2):450-63. https://doi.org/10.7150/thno.21668 PMid:29290820 PMCid:PMC5743560

Gerecke C, Edlich A, Giulbudagian M, Schumacher F, Zhang N, Said A, Yealland G, Lohan SB, Neumann F, Meinke MC, Ma N, Calderón M, Hedtrich S, Schäfer-Korting M, Kleuser B. Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes. Nanotoxicology. 2017; 11(2):267-77. https://doi.org/10.1080/17435390.2017.1292371 PMid:28165853

Ainbinder D, Godin B, Touitou E. Ethosomes: Enhanced delivery of drugs to and across the skin. In: Dragicevic N, Maibach HI (eds) Percutaneous Penetration Enhancers. Chemical Methods in Penetration Enhancement: Nanocarriers. Berlin Heidelberg: Springer, 2016:61-75. https://doi.org/10.1007/978-3-662-47862-2_4

Zhang YT, Shen LN, Wu ZH, Zhao JH, Feng NP. Comparison of ethosomes and liposomes for skin delivery of psoralen for psoriasis therapy. Int J Pharm. 2014; 471(1-2):449-52. https://doi.org/10.1016/j.ijpharm.2014.06.001 PMid:24907596

Garg BJ, Garg NK, Beg S, Singh B, Katare OP. Nanosized ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery against vitiligo: formulation optimization, in vitro evaluation and preclinical assessment. J Drug Target. 2016; 24(3):233-246. https://doi.org/10.3109/1061186X.2015.1070855 PMid:26267289

Bartelds R, Nematollahi MH, Pols T, Stuart MCA, Pardakhty A, Asadikaram G, Poolman B. Niosomes, an alternative for liposomal delivery. PLoS One. 2018; 13(4):e0194179. https://doi.org/10.1371/journal.pone.0194179 PMid:29649223 PMCid:PMC5896898

Abu Hashim II, Abo El-Magd NF, El-Sheakh AR, Hamed MF, Abd El-Gawad AEH. Pivotal role of Acitretin nanovesicular gel for effective treatment of psoriasis: ex vivo-in vivo evaluation study. Int J Nanomedicine. 2018; 13:1059-79. https://doi.org/10.2147/IJN.S156412 PMid:29503541 PMCid:PMC5824759

Kassem AA, Abd El-Alim SH, Asfour MH. Enhancement of 8-methoxypsoralen topical delivery via nanosized niosomal vesicles: Formulation development, in vitro and in vivo evaluation of skin deposition. Int J Pharm. 2017; 517(1-2):256-268. https://doi.org/10.1016/j.ijpharm.2016.12.018 PMid:27956194

Ahmad MZ, Mohammed AA, Mokhtar Ibrahim M. Technology overview and drug delivery application of proniosome. Pharm Dev Technol. 2017; 22(3):302-11. https://doi.org/10.3109/10837450.2015.1135344 PMid:26794727

Prasad V, Chaurasia S. Performance evaluation of non-ionic surfactant based tazarotene encapsulated proniosomal gel for the treatment of psoriasis. Mater Sci Eng C Mater Biol Appl. 2017; 79:168-176. https://doi.org/10.1016/j.msec.2017.05.036 PMid:28629004

Published
2019-08-30
How to Cite
1.
Wollina U, Tirant M, Vojvodic A, Lotti T. Treatment of Psoriasis: Novel Approaches to Topical Delivery. Open Access Maced J Med Sci [Internet]. 2019Aug.30 [cited 2020Nov.25];7(18):3018-25. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2019.414