Age Characteristics and Concomitant Diseases in Patients with Angioedema
Abstract
BACKGROUND: Angioneurotic oedema (AE) is an unpredictable and dangerous disease directly threatening the patient's life due to a sudden onset of upper respiratory tract obstruction. The disease is associated with various causes and triggering factors, but little is known about the conditions that accompany AE.
AIM: The study aims to determine the age-specificities and the spectrum of concomitant diseases in patients with AE.
MATERIAL AND METHODS: The subjects of observation were 88 patients (53 women and 35 men) with angioneurotic oedema who underwent diagnostics and treatment in the Department of Occupational Diseases and Clinical Allergology of University hospital “Saint Georgeâ€-Plovdiv.
RESULTS: The highest level of disease prevalence was found in the age group over 50 years, both in males (45.71%) and females (54.72%). We found that the most often concomitant diseases in our patients with AE are cardiovascular (33%). On second place are the patients with other accompanying conditions outside of the target groups (27.3%). Patients with AE and autoimmune thyroiditis were 14.8%, and those with AE and skeletal-muscle disorders-10.2%. Given the role of hereditary factors in this disease, the profession of the patients is considered insignificant.
CONCLUSION: Angioedema occurs in all age groups, but half of the cases are in people over 50 years of age. The most common concomitant diseases in angioedema are cardiovascular diseases.
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References
Bork K, Fischer B, Dewald G. Recurrent episodes of skin angioedema and severe attacks of abdominal pain induced by oral contraceptives or hormone replacement therapy. Am J Med. 2003; 114: 294-8. https://doi.org/10.1016/S0002-9343(02)01526-7
Bork K, Gul D, Dewald G. Hereditary angio-oedema with normal C1 inhibitor in a family with affected women and men. Br J Dermatol. 2006; 154:542–545. https://doi.org/10.1111/j.1365-2133.2005.07048.x PMid:16445789
Malde B, Regalado J, Greenberger PA. Investigation of angioedema associated with the use of angiotensinconverting enzyme inhibitors and angiotensin receptor blockers. Ann Allergy Asthma Immunol. 2007; 98:57-63. https://doi.org/10.1016/S1081-1206(10)60860-5
Longhurst H, Cicardi M. Hereditary angiooedema. Lancet. 2012; 379:474-81. https://doi.org/10.1016/S0140-6736(11)60935-5
Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA, Clark AT, Mirakian R, Walker SM, Huber PA, Nasser SM. BSACI guidelines for the management of chronic urticaria and angioâ€oedema. Clinical & Experimental Allergy. 2007; 37(5):631-50. https://doi.org/10.1111/j.1365-2222.2007.02678.x PMid:17456211
Powell R, Leech SC, Till S, Huber PA, Nasser SM, Clark AT. BSACI guideline for the management of chronic urticaria and angioedema. Clinical & Experimental Allergy. 2015; 45(3):547-65. https://doi.org/10.1111/cea.12494 PMid:25711134
Vazquez NF, Meida Arvizu VM, Sanchez Nuncio HR, Villanueva Carreto ML, Guidos Fogelbach GA. [Prevalence and potential triggering factors of chronic urticaria and angioedema in an urban area of northeastern Mexico.] Rev Alerg Mex. 2004; 51(5):181-8.
Zingale L, Beltrami L, Zanichelli A, Maggioni L, Pappalardo E, Cicardi B, Cicardi M. Angioedema without urticaria: a large clinical survey. CMAJ. 2006; 175(9):1065-70. https://doi.org/10.1503/cmaj.060535 PMid:17060655 PMCid:PMC1609157
Zuberbier T, Asero R, Bindslev-Jensen C, Walter Canonica G, Church MK, Gimenez- Arnau A et al. EAACI/GA(2)LEN/ EDF/WAO guideline: definition, classification and diagnosis of urticaria. Allergy. 2009; 64:1417–1426. https://doi.org/10.1111/j.1398-9995.2009.02179.x PMid:19772512
Zuberbier T, Balke M, Worm M, Edenharter G, Maurer M. Epidemiology of urticaria: a representative crosssectional population survey. Clin Exp Dermatol. 2010; 35:869–873. https://doi.org/10.1111/j.1365-2230.2010.03840.x PMid:20456386
Brickman CM, Tsokos GC, Balow JE, et al. Immunoregulatory disorders associated with hereditary angioedema. I. Clinical manifestations of autoimmune disease. J Allergy Clin Immunol. 1986; 77:749 –757. https://doi.org/10.1016/0091-6749(86)90424-0
Brickman CM, Tsokos GC, Thomas J.Lawley et al. Immunoregulatory disorders associated with hereditary angioedema: II. Serologic and cellular abnormalities. J Allergy Clin Immunol. 1986; 77:758-767. https://doi.org/10.1016/0091-6749(86)90425-2
Habal F, Huang V. Angioedema associated with Crohn's disease: response to biologics. World Journal of Gastroenterology: WJG. 2012; 18(34):4787. https://doi.org/10.3748/wjg.v18.i34.4787 PMid:23002350 PMCid:PMC3442219
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