Serum Iron Metabolism Variables in Clinically Healthy Persons

  • Mariana Penkova Department of Health care, Medical Faculty Trakia University, 11 Armeiska Street, 6000 Stara Zagora, Bulgaria
  • Nadezhda Ivanova Department of Health care, Medical Faculty Trakia University, 11 Armeiska Street, 6000 Stara Zagora, Bulgaria
Keywords: Iron homeostasis, Serum ferritin, Serum iron, Transferrin saturation, Chronic liver disease


BACKGROUND: In healthy persons, iron acquisition, trafficking and storage are strictly regulated processes due to the lack of a physiological pathway for the excretion of excess iron from the body. The liver, the duodenum and the bone marrow are involved in the regulation of iron metabolism.

MATERIAL: Subject to the testing were 60 healthy volunteers who took part in clinical trials.

METHODS: Case histories, physical check-up and demographic data including people’s heights and weights, laboratory studies and tests using medical equipment.

RESULTS: None of the healthy persons were reported to have shown any deviation from the reference values for the serum markers of iron metabolism tested with the exception of hepcidin.

CONCLUSION: In healthy persons, there was only a positive correlation between iron level and IBC, and feedback between hepcidin serum levels and transferrin saturation.


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Kaplan J, O'Halloran TV. Iron metabolism in eukaryotes: Mars and Venus at it again. Science. 1996; 271:1510-1512. PMid:8599104

Knutson M, Wessling-Resnick M. Iron metabolism in the reticuloendothelial system. Crit Rev Biochem Mol Biol. 2003; 38:61-88. PMid:12641343

Antonov K. Chronic viral hepatitis. Current state and prospects. Medinfo. 2007; 7(11): 30-32.

Gastroenterology and Hepatology, edited by Prof. Z. Krastev and Prof. K. Chernev (add year of publication).

Adzharov D, Petkova G, Koseva O. Iron as a pathogenetic factor in chronic HCV infection. Bulgarian Hepatogastroenterology. 2005; 2:33-37.

Grigorov N. Abdominal Echography in the Gastroenterology Manual. Diagnostics in a row. L Dinkov, S Stoynov. PIKS Ltd., Sofia, 1997:279-290.

Andrews NC. Disorders of iron metabolism. N Engl J Med. 1999; 341:1986-1995. PMid:10607817

Liu Z, Qiao J, Nagy T, Xiong MP. ROS-triggered degradable iron-chelating nanogels: Safely improving iron elimination in vivo. J Control Release. 2018; 283:84-93. PMid:29792889

Pietrangelo A. Pathogens, Metabolic Adaptation, and Human Diseases–An Iron-Thrifty Genetic Model. Gastroenterology. 2015; 149(4):834–838. PMid:26291901

Nai A, Lidonnici MR, Rausa M, et al. The second transferrin receptor regulates red blood cell production in mice. Blood. 2015; 125(7):1170–1179. PMid:25499454 PMCid:PMC4399753

Andrews NC, Iron metabolism: iron deficiency and iron overload, Annu Rev Genomics Hum Genet. 2000;1:75-98. PMid:11701625

Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004; 306(5704):2090–2093. PMid:15514116

Zumerle S, Mathieu JR, Delga S, et al. Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype. Blood. 2014; 123(23):3646–3650. PMid:24646470

Wang CY, Babitt JL. Hepcidin regulation in the anemia of inflammation. Curr Opin Hematol. 2016; 23(3):189–197. PMid:26886082 PMCid:PMC4993159

McCord JM. Iron, free radicals, and oxidative injury. Semin Hematol. 1998; 35:5-12. PMid:9460805

How to Cite
Penkova M, Ivanova N. Serum Iron Metabolism Variables in Clinically Healthy Persons. Open Access Maced J Med Sci [Internet]. 2019Feb.7 [cited 2021Jan.25];7(3):318-21. Available from:
A - Basic Science