Serum Iron Metabolism Variables in Clinically Healthy Persons

  • Mariana Penkova Department of Health care, Medical Faculty Trakia University, 11 Armeiska Street, 6000 Stara Zagora, Bulgaria
  • Nadezhda Ivanova Department of Health care, Medical Faculty Trakia University, 11 Armeiska Street, 6000 Stara Zagora, Bulgaria
Keywords: Iron homeostasis, Serum ferritin, Serum iron, Transferrin saturation, Chronic liver disease

Abstract

BACKGROUND: In healthy persons, iron acquisition, trafficking and storage are strictly regulated processes due to the lack of a physiological pathway for the excretion of excess iron from the body. The liver, the duodenum and the bone marrow are involved in the regulation of iron metabolism.

MATERIAL: Subject to the testing were 60 healthy volunteers who took part in clinical trials.

METHODS: Case histories, physical check-up and demographic data including people’s heights and weights, laboratory studies and tests using medical equipment.

RESULTS: None of the healthy persons were reported to have shown any deviation from the reference values for the serum markers of iron metabolism tested with the exception of hepcidin.

CONCLUSION: In healthy persons, there was only a positive correlation between iron level and IBC, and feedback between hepcidin serum levels and transferrin saturation.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Kaplan J, O'Halloran TV. Iron metabolism in eukaryotes: Mars and Venus at it again. Science. 1996; 271:1510-1512. https://doi.org/10.1126/science.271.5255.1510 PMid:8599104

Knutson M, Wessling-Resnick M. Iron metabolism in the reticuloendothelial system. Crit Rev Biochem Mol Biol. 2003; 38:61-88. https://doi.org/10.1080/713609210 PMid:12641343

Antonov K. Chronic viral hepatitis. Current state and prospects. Medinfo. 2007; 7(11): 30-32.

Gastroenterology and Hepatology, edited by Prof. Z. Krastev and Prof. K. Chernev (add year of publication).

Adzharov D, Petkova G, Koseva O. Iron as a pathogenetic factor in chronic HCV infection. Bulgarian Hepatogastroenterology. 2005; 2:33-37.

Grigorov N. Abdominal Echography in the Gastroenterology Manual. Diagnostics in a row. L Dinkov, S Stoynov. PIKS Ltd., Sofia, 1997:279-290.

Andrews NC. Disorders of iron metabolism. N Engl J Med. 1999; 341:1986-1995. https://doi.org/10.1056/NEJM199912233412607 PMid:10607817

Liu Z, Qiao J, Nagy T, Xiong MP. ROS-triggered degradable iron-chelating nanogels: Safely improving iron elimination in vivo. J Control Release. 2018; 283:84-93. https://doi.org/10.1016/j.jconrel.2018.05.025 PMid:29792889

Pietrangelo A. Pathogens, Metabolic Adaptation, and Human Diseases–An Iron-Thrifty Genetic Model. Gastroenterology. 2015; 149(4):834–838. https://doi.org/10.1053/j.gastro.2015.08.003 PMid:26291901

Nai A, Lidonnici MR, Rausa M, et al. The second transferrin receptor regulates red blood cell production in mice. Blood. 2015; 125(7):1170–1179. https://doi.org/10.1182/blood-2014-08-596254 PMid:25499454 PMCid:PMC4399753

Andrews NC, Iron metabolism: iron deficiency and iron overload, Annu Rev Genomics Hum Genet. 2000;1:75-98. https://doi.org/10.1146/annurev.genom.1.1.75 PMid:11701625

Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004; 306(5704):2090–2093. https://doi.org/10.1126/science.1104742 PMid:15514116

Zumerle S, Mathieu JR, Delga S, et al. Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype. Blood. 2014; 123(23):3646–3650. https://doi.org/10.1182/blood-2014-01-550467 PMid:24646470

Wang CY, Babitt JL. Hepcidin regulation in the anemia of inflammation. Curr Opin Hematol. 2016; 23(3):189–197. https://doi.org/10.1097/MOH.0000000000000236 PMid:26886082 PMCid:PMC4993159

McCord JM. Iron, free radicals, and oxidative injury. Semin Hematol. 1998; 35:5-12. PMid:9460805

Published
2019-02-07
How to Cite
1.
Penkova M, Ivanova N. Serum Iron Metabolism Variables in Clinically Healthy Persons. Open Access Maced J Med Sci [Internet]. 2019Feb.7 [cited 2021Jan.25];7(3):318-21. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2019.083
Section
A - Basic Science