The outcome of Pregnancy with Fetal Primitive Neuroectodermal Tumor

  • Vesna Livrinova University Clinic for Obstetrics and Gynecology, Skopje
  • Igor Petrov University Clinic for Neurology, Skopje
  • Adela Stefanija University Clinic for Obstetrics and Gynecology, Skopje
  • Jasminka Josheva Private Hospital Acibadem Sistina, Skopje
  • Viktorija Jovanovska University Clinic for Obstetrics and Gynecology, Skopje
  • Igor Samardziski University Clinic for Obstetrics and Gynecology Skopje
  • Selim Komina Institute for Pathology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Rubens Jovanovic Institute for Pathology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje
  • Ana Daneva-Markova University Clinic for Obstetrics and Gynecology Skopje
  • Slagjana Simeonova-Krstevska University Clinic for Obstetrics and Gynecology Skopje
  • Irena Todorovska University Clinic for Obstetrics and Gynecology Skopje
  • Ajla Shabani University Clinic for Obstetrics and Gynecology Skopje
Keywords: Fetus, Brain tumour, Outcome

Abstract

BACKGROUND: Fetal intracranial tumours are very rare. The overall incidence is 0.34 per one thousand live birth newborns. According to the new classification of central nervous system tumour (2016), a primitive neuroectodermal tumour of (PNETs) is an embryonal tumour group; these are tumours with high malignancy and belong to group IV (WHO). In our case, we will present a case of PNETs in 28 gestation week old fetus, diagnosed antenatally and confirmed postnatally.

CASE REPORT: We present the third pregnancy in 29 years old patient, with two previous term deliveries of healthy newborn. She came to University clinic at 27+3 gestational week for fetal hydrocephalus. After an ultrasound and MRI scan, possibilities were explained to the parents. During the medico-ethical counselling, explain to the parents the need for operation and the possibility of postoperative adjuvant therapy, quality of life with potential future disabilities. They choose to terminate the pregnancy. Postmortem the diagnosis was PNETs. Summary of analysis: peripheral neuroectodermal tumour with ganglion and neuronal differentiation

CONCLUSION: Antenatal management depends on the gestational week in the time of diagnosis and the decision of parents. If the lesion is before viability fetus, it should be offered termination of pregnancy. Another important factor is the mode of delivery, because of increased intracranial pressure although this aggressive combined modality of treatment, recurrence is often. Tree year of survival is between 53% and 73% when the adjuvant radiotherapy is included. For that, they should be diagnosed as soon as possible before achieving fetal viability. Only 18% of those tumours presenting in the first year of life are diagnosed before or at delivery.

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References

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Published
2018-08-17
How to Cite
1.
Livrinova V, Petrov I, Stefanija A, Josheva J, Jovanovska V, Samardziski I, Komina S, Jovanovic R, Daneva-Markova A, Simeonova-Krstevska S, Todorovska I, Shabani A. The outcome of Pregnancy with Fetal Primitive Neuroectodermal Tumor. Open Access Maced J Med Sci [Internet]. 2018Aug.17 [cited 2020Nov.29];6(8):1450-3. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2018.316
Section
C- Case Reports