Primary Cutaneous CD30+/ALK- ALCL with Transition into sALCL: Favourable Response after Systemic Administration with Brentuximab Vedotin! Unique Presentation in a Bulgarian Patient!

  • Tanya Naskova Popova Department of Clinical Hematology, University Multiprofile Hospital for Active Treatment “Sveti Ivan Rilski”, Sofia 15, Acad. Ivan Geshov Blvd., Sofia 1431
  • Atanass Radinov Department of Clinical Hematology, University Multiprofile Hospital for Active Treatment “Sveti Ivan Rilski”, Sofia 15, Acad. Ivan Geshov Blvd., Sofia 1431
  • Konstantin Stavrov Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia
  • Ivanka Temelkova Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia
  • Ivan Terziev Universitetska Mnogoprofilno Bolnitsa za Aktivno Lechenie "Tsaritsa Yoanna", Common and Clinical Pathology, Sofia
  • Ilia Lozev Medical Institute of the Ministry of Interior, Surgery, Sofia
  • Detelina Lukanova National Hospital of Cardiology, Clinic of Vascular surgery and Angiology, Sofia
  • Hristo Mangarov Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia
  • Uwe Wollina Städtisches Klinikum Dresden, Department of Dermatology and Allergology, Friedrichstrasse 41, Dresden
  • Georgi Tchernev Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia; Onkoderma, Policlinic for Dermatology and Dermatologic Surgery, General Skobelev 26, Sofia
Keywords: Anaplastic large, T cell lymphoma, Brentuximab, Remission, CD30

Abstract

BACKGROUND: Modern drugs could sometimes be a good solution even to problematic patients. The cutaneous and systemic forms of the CD30 positive anaplastic large T-cell lymphoma could often be described as a suitable target for therapy with Brentuximab vedotin.

CASE REPORT: We present the first case of a Bulgarian patient with a histologically confirmed primary cutaneous T-cell CD30+/ALK- large anaplastic cell lymphoma-cALCL (therapeutically resistant to therapy with Methotrexate, radiation therapy and systemic corticosteroid therapy) who was successfully treated with Brentuximab vedotin. In several years, the patient has developed a comparatively fast skin progression as well as an initial systemic one which impacts inguinal and mediastinal nodes. After the implementation of 4 therapy cycles with Brentuximab vedotin, complete regression of the described by previous hospitalisations lymph nodes as well as 80% reduction of the cutaneous and subcutaneous located tumour formations were observed.

CONCLUSION: The therapy of CD30+/ALK- anaplastic large T-cell lymphoma is a significant challenge for oncologists and dermatologists because it requires maximally efficient and minimally traumatic treatment in parallel. Therapy with Brentuximab is a new direction which shows extremely good clinical results and can be applied to the cutaneous as well as to the systemic form of anaplastic large-cell CD30 positive lymphoma. The key element by treatment with Brentuximab is suppression of the CD30- expression which, in turn, could be the cause of relapses. On that ground, patients with these lymphomas should be strictly monitored.

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Published
2018-07-12
How to Cite
1.
Popova TN, Radinov A, Stavrov K, Temelkova I, Terziev I, Lozev I, Lukanova D, Mangarov H, Wollina U, Tchernev G. Primary Cutaneous CD30+/ALK- ALCL with Transition into sALCL: Favourable Response after Systemic Administration with Brentuximab Vedotin! Unique Presentation in a Bulgarian Patient!. Open Access Maced J Med Sci [Internet]. 2018Jul.12 [cited 2020Nov.25];6(7):1275-7. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2018.289
Section
C- Case Reports

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