An Investigation of the Prevalence of Subclinical Brain Lesions in MRI Images of Migraine Patients
BACKGROUND: The use of the MRI method has opened up a new perspective on pathogenesis, diagnosis and treatment of brain lesions.
AIM: Therefore, this study aimed to evaluate the prevalence of brain subclinical lesions in MRI images of migraine patients.
METHODS: This cross-sectional study was conducted on 300 patients with a migraine referred to Baqiyatallah and Amir Al-Momenin Hospitals from 2005 to 2006. We measured the relationship between the results of MRI and the type of brain subclinical lesion by indices such as age, gender, type of a migraine, the number of migraine attacks, blood pressure and heart diseases, cholesterol, diabetes and thyroid diseases. Finally, data were analysed by IBM SPSS statistics software version 23. The significance level in this study was considered as P > 0.05.
RESULTS: From among 300 patients, 87.7% were women in the age range of 13-72 years. Moreover, the results indicated that with increasing age, blood pressure and some migraine attacks, the frequency of abnormal MRI also is increased significantly as well as the ratio of a migraine with aura was significantly higher than a migraine without aura in individuals with abnormal MRI. Also, the ratio of white matter lesions (WML) is higher in a classical migraine (a Migraine with aura). Statistical analyses did not reveal any significant relationship between MRI results on age, diabetes, cholesterol, heart and thyroid diseases.CONCLUSION: The prevalence of abnormal MRI in older people and those with high blood pressure and migraine with aura is higher, and the ratio of subclinical lesions in the population of a migraine with aura is more common than a migraine without aura.
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Haji Naghi Tehrani Kh, Mousavi F, Shojaei A. Prevalence of epilepsy in migraine patients and their first-degree relatives. International Research Journal of Applied and Basic Sciences. 2015; 9(4):482-484.
Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache. 2001; 41(7):646-57. https://doi.org/10.1046/j.1526-4610.2001.041007646.x PMid:11554952
Burch RC, Loder S, Loder E, Smitherman TA. The prevalence and burden of migraine and severe headache in the United States: updated statistics from government health surveillance studies. Headache. 2015; 55:1-21. https://doi.org/10.1111/head.12482 PMid:25600719
Stovner LJ, Andree C. Prevalence of headache in Europe: a review for the Eurolight project. The journal of headache and pain. 2010; 11(4):289-99. https://doi.org/10.1007/s10194-010-0217-0 PMid:20473702 PMCid:PMC2917556
Nazari F, Eghbali M. Migraine and its relationship with dietary habits in women. Iranian Journal of Nursing and Midwifery Research. 2012; 17(2 Suppl 1):S65-S71. PMid:23833603 PMCid:PMC3696968
Manzoni GC, Torelli P. Epidemiology of migraine. The journal of headache and pain. 2001; 2(Suppl 1):s11-s3. https://doi.org/10.1007/s101940170002 PMCid:PMC3451821
Min YW, Lee JH, Min B-H, Lee JH, Kim JJ, Chung C-S, et al. Clinical Predictors for Migraine in Patients Presenting With Nausea and/or Vomiting. Journal of Neurogastroenterology and Motility. 2013; 19(4):516-20. https://doi.org/10.5056/jnm.2013.19.4.516 PMid:24199013 PMCid:PMC3816187
Weatherall MW. The diagnosis and treatment of chronic migraine. Therapeutic Advances in Chronic Disease. 2015; 6(3):115-23. https://doi.org/10.1177/2040622315579627 PMid:25954496 PMCid:PMC4416971
Zhang Y, Parikh A, Qian S. Migraine and stroke. Stroke and Vascular Neurology. 2017; 2(3):160-7. https://doi.org/10.1136/svn-2017-000077 PMid:28989805 PMCid:PMC5628377
Gaul C, Messlinger K, Holle-Lee D, Neeb L. [Pathophysiology of Headaches]. Deutsche medizinische Wochenschrift. 2017; 142(6):402-8. https://doi.org/10.1055/s-0042-111694 PMid:28329901
Spector JT, Kahn SR, Jones MR, Jayakumar M, Dalal D, Nazarian S. Migraine headache and ischemic stroke risk: an updated meta-analysis. The American journal of medicine. 2010; 123(7):612-24. https://doi.org/10.1016/j.amjmed.2009.12.021 PMid:20493462 PMCid:PMC2900472
Schurks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ (Clinical research ed). 2009; 339:b3914. https://doi.org/10.1136/bmj.b3914 PMid:19861375 PMCid:PMC2768778
Kruit MC, van Buchem MA, Launer LJ, Terwindt GM, Ferrari MD. Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: The population-based MRI CAMERA-study. Cephalalgia. An international journal of headache. 2010; 30(2):129-36.
Swartz RH, Kern RZ. Migraine is associated with magnetic resonance imaging white matter abnormalities: a meta-analysis. Arch Neurol. 2004; 61(9):1366-8. https://doi.org/10.1001/archneur.61.9.1366 PMid:15364681
Bashir A, Lipton RB, Ashina S, Ashina M. Migraine and structural changes in the brain: A systematic review and meta-analysis. Neurology. 2013; 81(14):1260-8. https://doi.org/10.1212/WNL.0b013e3182a6cb32 PMid:23986301 PMCid:PMC3795609
Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD, et al. Migraine as a risk factor for subclinical brain lesions. Jama. 2004; 291(4):427-34. https://doi.org/10.1001/jama.291.4.427 PMid:14747499
Trauninger A, LeÃ©l-Åssy E, Kamson DO, PÃ³tÃ³ L, Aradi M, KÃ¶vÃ©r F, Imre M, KomÃ¡romy H, ErdÃ©lyi-Botor S, PatzkÃ³ Ã, Pfund Z. Risk factors of migraine-related brain white matter hyperintensities: an investigation of 186 patients. The journal of headache and pain. 2011; 12(1):97-103. https://doi.org/10.1007/s10194-011-0299-3 PMid:21331756 PMCid:PMC3056006
Erdelyi-Botor S, Aradi M, Kamson DO, Kovacs N, Perlaki G, Orsi G, et al. Changes of migraine-related white matter hyperintensities after 3 years: a longitudinal MRI study. Headache. 2015; 55(1):55-70. https://doi.org/10.1111/head.12459 PMid:25319529
Le Pira F, Reggio E, Quattrocchi G, Sanfilippo C, Maci T, Cavallaro T, et al. Executive dysfunctions in migraine with and without aura: what is the role of white matter lesions? Headache. 2014; 54(1):125-30. https://doi.org/10.1111/head.12158 PMid:23808818
Finocchi C, Sassos D. Headache and arterial hypertension. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2017; 38(Suppl 1):67-72.
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