The Relationship between Serum Vitamin D Levels with Allergic Rhinitis Incidence and Total Nasal Symptom Score in Allergic Rhinitis Patients

  • Lia Restimulia Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Airlangga University, Jl. Prof. Dr Moestopo No. 47, Surabaya 60132
  • Dwi Reno Pawarti Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Airlangga University, Jl. Prof. Dr Moestopo No. 47, Surabaya 60132
  • Haris Mayaguyang Ekorini Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Airlangga University, Jl. Prof. Dr Moestopo No. 47, Surabaya 60132
Keywords: Allergic rhinitis, 25-hydroxyvitamin D, Allergic diseases, Total nasal symptom score, Cut-off points

Abstract

BACKGROUND: Allergic diseases and vitamin D deficiency were found to have a relationship. However, there was limited number of studies on the relationship between vitamin D with allergic rhinitis (AR) and total nasal symptom scores (TNSS), particularly in determining the cut-off points of serum vitamin D levels which correlated to AR.

AIM: As this particular study has never been conducted in Indonesia, the main objective of this study was to investigate this issue.

METHODS: The research was conducted at Dr Soetomo Hospital, Surabaya in January 2017. A group of 30 subjects were recruited using consecutive sampling. Levels of serum vitamin D were measured using electrochemiluminescence immunoassay (ECLIA) method while the total nasal symptom scores were obtained by accumulating all the nasal symptoms. Data of serum vitamin D levels and TNSS were analysed statistically with the Pearson correlation test.

RESULTS: It was found that the mean of serum 25(OH) vitamin D levels (9.13 ng/mL) of the AR group was significantly lower than the non-AR group (26.22 ng/mL) (P = 0.000). The vitamin D cut-off points which correlated to AR was about 12.83 ng/mL (sensitivity = 80%; specificity = 100%). A Pearson correlation test found a strong, negative correlation between vitamin D levels and TNSS (P = 0.000; r = -0.800).

CONCLUSION: There was a strong, negative correlation between serum vitamin D levels with AR and TNSS. The cut-off points of serum vitamin D levels correlated to AR were approximately12.83 ng/mL. Thus, further research needs to be conducted.

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Published
2018-08-10
How to Cite
1.
Restimulia L, Pawarti DR, Ekorini HM. The Relationship between Serum Vitamin D Levels with Allergic Rhinitis Incidence and Total Nasal Symptom Score in Allergic Rhinitis Patients. Open Access Maced J Med Sci [Internet]. 2018Aug.10 [cited 2020Nov.27];6(8):1405-9. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2018.247
Section
B - Clinical Sciences