A Case of the Co-Existence of Subcorneal Pustular Dermatosis and Pyoderma Gangrenosum and a Review of the Literature

  • Maria Ferrillo Section of Dermatology, Department of Clinical Medicine and Surgery, Dermatology Unit, University of Naples Federico II, Napoli
  • Alessia Villani Section of Dermatology, Department of Clinical Medicine and Surgery, Dermatology Unit, University of Naples Federico II, Napoli
  • Gabriella Fabbrocini Section of Dermatology, Department of Clinical Medicine and Surgery, Dermatology Unit, University of Naples Federico II, Napoli
  • Massimo Mascolo Department of Advanced Biomedical Sciences, Pathology Section University of Naples Federico II, Napoli
  • Matteo Megna Section of Dermatology, Department of Clinical Medicine and Surgery, Dermatology Unit, University of Naples Federico II, Napoli
  • Claudia Costa Section of Dermatology, Department of Clinical Medicine and Surgery, Dermatology Unit, University of Naples Federico II, Napoli
  • Maddalena Napolitano Department of Medicine and Health Science "Vincenzo Tiberio", University of Molise, Campobasso
Keywords: Subcorneal pustular dermatosis, Pyoderma gangrenosum, Sneddon-Wilkinson disease, neutrophilic dermatoses

Abstract

BACKGROUND: Subcorneal pustular dermatosis, also known as Sneddon-Wilkinson disease, can be classified as one of the neutrophilic dermatoses together with pyoderma gangrenosum. The development of both SPD and PG in the same patient has rarely been reported and may be a strong indicator of IgA dysglobulinemia

CASE REPORT: We report the case of a 34-year-old woman with a 2-year history of relapsing pustular eruptions mainly affecting the abdomen, gluteus region, elbows, and the extremities. Four years after the onset of subcorneal pustular dermatosis (SPD), she developed pyoderma gangrenosum (PG) on her right hand. In literature, the coexistence of SPD and PG in the same patient has already been described. This co-occurrence might indicate a certain predisposition for immune dysregulation.

CONCLUSION: Although the two NDs are often associated with systemic diseases, these patients should be followed up for any malignancy because of the strong association between these disorders.

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Published
2018-07-08
How to Cite
1.
Ferrillo M, Villani A, Fabbrocini G, Mascolo M, Megna M, Costa C, Napolitano M. A Case of the Co-Existence of Subcorneal Pustular Dermatosis and Pyoderma Gangrenosum and a Review of the Literature. Open Access Maced J Med Sci [Internet]. 2018Jul.8 [cited 2020Nov.27];6(7):1271-4. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2018.214
Section
C- Case Reports