Palatal Melanoma: ʺThe Silent Killerʺ

  • Georgi Tchernev Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, Sofia; Onkoderma - Policlinic for Dermatology and Dermatologic Surgery, Sofia
  • Torello Lotti Department of Dermatology, University of Rome “G. Marconi” Rome, Italy; 4Department of Biotechnology, Delft University of Technology, 2628 BC, Delft
  • Uwe Wollina Städtisches Klinikum Dresden, Department of Dermatology and Allergology, Dresden, Sachsen
Keywords: Palatal, Melanoma, Killer, Surgery, Progression

Abstract

Primary melanoma of the oral cavity is extremely uncommon tumour consisting approximately 0.2 - 8.0% of all melanoma cases and 0.5% of all oral malignancies. It has an aggressive behaviour and poor prognosis, with 5 – year - survival rate between 5 - 20%. The initial symptoms are often unnoticed, which lead to late diagnosis and worsening of the prognosis. Because of its infrequent occurrence, there is no well - defined classification and therapeutic protocol, in contrast to melanomas of another side. Early diagnosis and treatment are essentially linked to survival rate. We present a case of palatal melanoma in a 76 – year - old female patient, as we want to emphasise the importance of the early detection and accurate diagnosis of melanoma of oral cavity, to its influence of the therapeutic outcome.

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References

Alqahtani S, Alhefdhi AY, Almalik O, Anwar I, Mahmood R, Mahasin Z, Al-Tweigeri T. Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review. Oncol Lett. 2017; 14(2):1275-1280. https://doi.org/10.3892/ol.2017.6304 PMid:28789341 PMCid:PMC5529946

Kumar V, Vishnoi JR, Kori CG, Gupta S, Misra S, Akhtar N. Primary malignant melanoma of oral cavity: A tertiary care center experience. Natl J Maxillofac Surg. 2015; 6(2):167-71. https://doi.org/10.4103/0975-5950.183856 PMid:27390490 PMCid:PMC4922226

Padhye A, D'souza J. Oral malignant melanoma: A silent killer? J Indian Soc Periodontol. 2011; 15(4): 425–428. https://doi.org/10.4103/0972-124X.92587 PMid:22368374 PMCid:PMC3283947

Rathore RS, Phulari RG, Vasavada DG, Patel DK. A Rare and Extensive Case of Oral Malignant Melanoma involving Mandibular Gingiva. J Clin Diagn Res. 2016; 10(2):ZD11-2. https://doi.org/10.7860/JCDR/2016/17423.7320

Ferreira L, Jham B, Assi R, Readinger A, Kessler HP. Oral melanocytic nevi: a clinicopathologic study of 100 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 120(3):358-67. https://doi.org/10.1016/j.oooo.2015.05.008 PMid:26297393

Guevara-Canales J, Gutiérrez-Morales MM, Sacsaquispe-Contreras SJ, Sánchez-Lihón J, Morales-Vadillo R. Malignant melanoma of the oral cavity. Review of the literature and experience in a Peruvian Population. Med Oral Patol Oral Cir Bucal. 2012; 17(2): e206–e211. https://doi.org/10.4317/medoral.17477 PMid:22143709 PMCid:PMC3448307

Martinelli-Kläy CP, Laporte ML, Martinelli CR, Martinelli C, Lombardi T. Oral Malignant Melanoma Initially Misdiagnosed as a Racial Pigmentation: A Case Report. Dermatopathology (Basel). 2016; 3(1):1-7. https://doi.org/10.1159/000444049 PMid:27195264 PMCid:PMC4868936

Lopez-Graniel CM, Ochoa-Carrillo FJ, Meneses-García A. Malignant melanoma of the oral cavity: diagnosis and treatment experience in a Mexican population. Oral Oncol. 1999; 35(4):425-30. https://doi.org/10.1016/S1368-8375(99)00017-2

Ebenezer J. Malignant melanoma of the oral cavity. Indian J Dent Res. 2006; 17(2):94-6. https://doi.org/10.4103/0970-9290.29882 PMid:17051877

Westbury G: Malignant melanoma of the skin, In: Lumley J. Cravin J, (Ed.) Surgical Review. Pitrnan Medical, 1979; 1:24-36.

Barker BF, Carpenter WM, Daniels TE, Kahn MA, Leider AS, Lozada-Nur F. Oral mucosal melanomas: the WESTOP Banff workshop proceedings Western Society of Teachers of Oral Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997; 83:672–679. https://doi.org/10.1016/S1079-2104(97)90318-8

Prasad ML, Patel SG, Huvos AG, Shah JP, Busam KJ. Primary mucosal melanoma of the head and neck: a proposal for microstaging localized, Stage I (lymph node-negative) tumors. Cancer. 2004; 100(8):1657-64. https://doi.org/10.1002/cncr.20201 PMid:15073854

Aguas SC, Quarracino MC, Lence AN, Lanfranchi-Tizeira HE. Primary melanoma of the oral cavity: ten cases and review of 177 cases from literature. Med Oral Patol Oral Cir Bucal. 2009; 14(6):E265-71. PMid:19300378

Bujas T, Pavić I, Prus A, Marusić Z, Balicević D. Primary oral malignant melanoma: case report. Acta Clin Croat. 2010; 49(1):55-9. PMid:20635585

Banerjee SS, Harris M. Morphological and immunophenotypic variations in malignant melanoma. Histopathology. 2000; 36:387–402. https://doi.org/10.1046/j.1365-2559.2000.00894.x

Meleti M, Leemans CR, Mooi WJ, Vescovi P, van der Waal I. Oral malignant melanoma: A review of the literature. Oral Oncol. 2007; 43:116–21. https://doi.org/10.1016/j.oraloncology.2006.04.001 PMid:16931116

Gupta S, Tandon A, Ram H, Gupta O. Oral malignant melanoma: Report of three cases with literature review. Natl J Maxillofac Surg. 2015; 6(1):103-9. https://doi.org/10.4103/0975-5950.168239 PMid:26668465 PMCid:PMC4668719

Hicks MJ, Flaitz CM. Oral mucosal melanoma: Epidemiology and pathobiology. Oral Oncol. 2000; 36:152–69. https://doi.org/10.1016/S1368-8375(99)00085-8

Singh H, Kumar P, Augustine J, Urs AB, Gupta S. Primary malignant melanoma of oral cavity: A report of three rare cases. Contemp Clin Dent. 2016; 7(1):87-9. .https://doi.org/10.4103/0976-237X.177094 PMid:27041909 PMCid:PMC4792064

Naganawa K, Koto M, Takagi R, Hasegawa A, Ikawa H, Shimozato K, Kamada T, Okamoto Y; Organizing Committee for the Working Group for Head-and-Neck Cancer. Long-term outcomes after carbon-ion radiotherapy for oral mucosal malignant melanoma. J Radiat Res. 2016. https://doi.org/10.1093/jrr/rrw117 PMid:28028129 PMCid:PMC5570020

Published
2018-01-28
How to Cite
1.
Tchernev G, Lotti T, Wollina U. Palatal Melanoma: ʺThe Silent Killerʺ. Open Access Maced J Med Sci [Internet]. 2018Jan.28 [cited 2020Nov.29];6(2):364-6. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2018.071
Section
C- Case Reports

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