Histopathological Pattern and Age Distribution, of Malignant Ovarian Tumor among Sudanese Ladies
INTRODUCTION: Ovarian cancer is the cause of a high case-fatality ratio, and most of the cases are diagnosed in late stages.
OBJECTIVES: To determine the histopathological types, age distribution, and ovarian tumour stages among diagnosed with ovarian cancer at Al - Amal Tower a multi-referral polyclinic of Radiology & Isotope Center Khartoum (RICK), Sudan.
METHODS: All histopathology reports patients' case from January to June 2015 were reviewed. The cancers classified according to federation international of Obstetrics and Gynecology (FIGO).
RESULTS: There were 127 cases of ovarian cancers. Surface epithelial cancers were the most common 77.7% ( n = 98), followed by sex cord-stromal cancers 11.23% (n = 14), Germ cell tumor 1.6% (n = 2). Metastatic cancers were seen from colon and breast in 6.3% and 3.9 % of cases respectively. Few cases (14%) of ovarian cancers were reported before 40 years of age, after the age of 50 is a sharp increase in the incidence of a tumour. The mean age at presentation was 52.36 Â± 14.210 years, there is mean age of menarche 13.59 Â± 2.706 years. Very few patients used HRT (1.6%) or had been on ovulation induction treatment (8.7%). Most of patients 39 (30.7%) presented in stage IIIC, and stage 1V 32 (25.2%) indicating a poor prognosis.CONCLUSION: The incidence of different types of ovarian cancers in the present study is similar to worldwide incidence. The surface epithelial tumour is the commonest ovarian cancer, of which serous adenocarcinoma is the commonest and most of our patients present in late stages.
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Markman, M. Development of an ovarian cancer symptom index: Possibilities for earlier detection. J Cancer. 2007; 110(1):226-27. https://doi.org/10.1002/cncr.22749 PMid:17486562
Ryerson AB, Eheman C, Burton J, McCall N, Blackman D, Subramanian S, et al. Symptoms, diagnoses, and time to key diagnostic procedures among older US women with ovarian cancer. Obstetrics & Gynecology. 2007; 109(5):1053-61. https://doi.org/10.1097/01.AOG.0000260392.70365.5e PMid:17470582
Ofor IE, Obeagu K, Ochei, Odo M. International Journal Of Current Research In Chemistry And Pharmaceutical Sciences. Int J Curr Res Chem Pharm Sci. 2016; 3(2):20-28.
Ganesan K, Morani AC, Marcal LP, Bhosale PR, and Elsayes KM. Cross-Sectional Imaging of the Uterus, in Cross-Sectional Imaging of the Abdomen and Pelvis. Springer, 2015:875-936. https://doi.org/10.1007/978-1-4939-1884-3_27
Yazbek JK, Raju J, Ben-Nagi TK, Holland K, Hillaby, Jurkovic D. Effect of quality of gynaecological ultrasonography on the management of patients with suspected ovarian cancer: a randomised controlled trial. The Lancet Oncology. 2008; 9(2):124-31. https://doi.org/10.1016/S1470-2045(08)70005-6
Acharya UR, Molinari F, Sree SV, Swapna G, Saba L, Guerriero S, et al. Ovarian Tissue Characterization in ultrasound a review. Technology in cancer research & treatment. 2015; 14(3):251-61. https://doi.org/10.1177/1533034614547445 PMid:25230716
Moyer VA. Screening for ovarian cancer: US Preventive Services Task Force reaffirmation recommendation statement. Annals of internal medicine. 2012; 157(12):900-04. https://doi.org/10.7326/0003-4819-157-11-201212040-00539 PMid:22964825
Bapat SA, Mali AM, Koppikar CB, Kurrey NK. Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. Cancer Research. 2005; 65(8):3025-29. https://doi.org/10.1158/0008-5472.CAN-04-3931 PMid:15833827
Vang R, Shih IM, Kurman RJ. Fallopian tube precursors of ovarian lowâ€and highâ€grade serous neoplasms. Histopathology. 2013; 62(1):44-58. https://doi.org/10.1111/his.12046 PMid:23240669
Beckmeyer-Borowko AB, Peterson CE, Brewer KC, Otoo MA, Davis FG, Hoskins KF, et al. The effect of time on racial differences in epithelial ovarian cancer (OVCA) diagnosis stage, overall and by histologic subtypes: a study of the National Cancer Database. Cancer Causes & Control. 2016; 27(10):1261-71. https://doi.org/10.1007/s10552-016-0806-6 PMid:27590306 PMCid:PMC5418550
Wright JD, Chen L, Tergas AI, Patankar S, Burke WM, Hou JY, et al. Trends in relative survival for ovarian cancer from 1975 to 2011. Obstetrics and gynecology. 2015; 125(6):1345. https://doi.org/10.1097/AOG.0000000000000854 PMid:26000505 PMCid:PMC4484269
Wentzensen N, Poole EM, Trabert B, White E, Arslan AA, Patel AV, et al. Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium. J Clin Oncol. 2016; 34(24):2888-98. https://doi.org/10.1200/JCO.2016.66.8178 PMid:27325851 PMCid:PMC5012665
Parazzini F, Franceschi S, La Vecchia C, Fasoli M.The epidemiology of ovarian cancer. Gynecologic oncology. 1991; 43(1):9-23. https://doi.org/10.1016/0090-8258(91)90003-N
Terada T. Endometrioid adenocarcinoma of the ovary arising in atypical endometriosis. International journal of clinical and experimental pathology. 2012; 5(9):924. PMid:23119109 PMCid:PMC3484489
Akakpo PK, Derkyi-Kwarteng L, Gyasi RK, Quayson SE, Anim JT. Ovarian Cancer in Ghana, a 10 Year Histopathological Review of Cases at Korle Bu Teaching Hospital. African Journal of Reproductive Health. 2015; 19(4):102-06. PMid:27337859
Gong TT, Wu QJ, Vogtmann E, Lin B, Wang YL.Age at menarche and risk of ovarian cancer: a meta-analysis of epidemiological studies. Int J Cancer. 2013;132(12):2894-900. https://doi.org/10.1002/ijc.27952 PMid:23175139 PMCid:PMC3806278
Winn ML, Lee NC, Rhodes PH, Layde PM, Rubin GL. Pregnancy, breast feeding, and oral contraceptives and the risk of epithelial ovarian cancer. J Clin Epidemiol. 1990; 43:559-568. https://doi.org/10.1016/0895-4356(90)90160-Q
Collaborative Group On Epidemiological Studies Of Ovarian Cancer, Beral V, Gaitskell K, Hermon C, Moser K, Reeves G, Peto R. Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies. Lancet. 2015; 385(9980):1835-42. https://doi.org/10.1016/S0140-6736(14)61687-1
Horta M, Cunha TM. Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists. Diagnostic and Interventional Radiology. 2015; 21(4):277. https://doi.org/10.5152/dir.2015.34414 PMid:26054417 PMCid:PMC4498422
Levitin A, Haller K, Cohen HL, Zinn DL, O'Connor M. Endodermal sinus tumor of the ovary: imaging evaluation. AJR. American journal of roentgenology. 1996; 167(3):791-93. https://doi.org/10.2214/ajr.167.3.8751702 PMid:8751702
Stewart CJ, Leung YC, Whitehouse A. Fallopian tube metastases of nonâ€gynaecological origin: a series of 20 cases emphasizing patterns of involvement including intraâ€epithelial spread. Histopathology. 2012; 60(6B):E106-E14. https://doi.org/10.1111/j.1365-2559.2012.04194.x PMid:22394169
Micci F, Haugom L, Ahlquist T, Abeler VM, Trope CG, Lothe RA, et al. Tumor spreading to the contralateral ovary in bilateral ovarian carcinoma is a late event in clonal evolution. Journal of oncology. 2009; 2010.
Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and Cotran pathologic basis of disease. Elsevier Health Sciences, 2014.
Pejovic T, Heim S, Mandahl N, Elmfors B, Furgyik S, FlodÃ©rus UM, et al. Bilateral ovarian carcinoma: cytogenetic evidence of unicentric origin. International journal of cancer. 1991; 47(3):358-61. https://doi.org/10.1002/ijc.2910470308 PMid:1993543
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