Micro - Focused Phototherapy Associated To Janus Kinase Inhibitor: A Promising Valid Therapeutic Option for Patients with Localized Vitiligo

  • Serena Gianfaldoni University G. Marconi of Rome - Dermatology and Venereology, University G. Marconi of Rome, Rome
  • Georgi Tchernev Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, Sofia
  • Uwe Wollina Städtisches Klinikum Dresden, Department of Dermatology and Venereology, Dresden, Sachsen
  • Maria Grazia Roccia University B.I.S. Group of Institutions, Punjab Technical University, Punjab
  • Massimo Fioranelli G. Marconi University - Department of Nuclear Physics, Subnuclear and Radiation, Rome
  • Jacopo Lotti G. Marconi University - Department of Nuclear Physics, Subnuclear and Radiation, Rome
  • Miriam Rovesti Department of Dermatology, University of Parma, Parma
  • Francesca Satolli Department of Dermatology, University of Parma, Parma
  • Yan Valle Vitiligo Research Foundation, New York
  • Andy Goren Department of Dermatology, University G. Marconi of Rome, Rome
  • Michael Tirant Psoriasis & Skin Clinic, 374 Nepean Highway Frankston Victoria, Melbourne 3199
  • Mirna Situm Department of Dermato-Venereology, Zagreb University Hospital Center Sisters of Charity, University of Zagreb, Zagreb
  • Maja Kovacevic Department of Dermato-Venereology, Zagreb University Hospital Center Sisters of Charity, University of Zagreb, Zagreb
  • Katlein França University of Miami School of Medicine Ringgold standard institution, Miami, Florida
  • Torello Lotti University G. Marconi of Rome, Dermatology and Venereology, Rome
Keywords: Vitiligo, Micro – phototherapy, BIOSKIN EVOLUTION®, Janus kinase inhibitor, Tofacitinib, Repigmentation

Abstract

BACKGROUND: Vitiligo is an acquired pigmentary cutaneous disease, characterised by the progressive loss of melanocytes, resulting in hypopigmented skin areas which progressively become amelanotic. Classically, vitiligo treatments are unsatisfactory and challenging. Despite the continuous introduction of new therapies, phototherapy is still the mainstay for vitiligo repigmentation.

AIM: The aim of this multicenter observational retrospective study was to evaluate the efficacy and safety of the nb - UVB micro - phototherapy (BIOSKIN EVOLUTION®), used alone or in associations with an oral Janus kinase inhibitor (Tofacitinib citrate), in the treatment of stable or active forms of localised vitiligo.

MATERIAL AND METHODS: Fifty eight patients had been treated with n-UVB micro-photootherapy (Group A); 9 patients had been treated with phototherapy plus Tofacitinb citrate (Group B).

RESULTS: Among Group A, 42 patients (72%) obtained a re-pigmentation rate higher than 75%, with a medium value of 77%. 11 patients (19%) achieved a marked improvement of the clinical findings with a repigmentation rate between 50-75%; 4 patients (8%) showed a moderate response with a lesional repigmentation of 25-50%. Only one patient (1%) had a poor response to the phototherapeutic treatment

CONCLUSION: Nb - UVB micro-focused phototherapy is one of the most effective therapeutic options for vitiligo treatment. The association of micro-focused phototherapy to Tofacitinib citrate seems to provide better clinical results in term of repigmentation rate.

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Published
2018-01-21
How to Cite
1.
Gianfaldoni S, Tchernev G, Wollina U, Roccia MG, Fioranelli M, Lotti J, Rovesti M, Satolli F, Valle Y, Goren A, Tirant M, Situm M, Kovacevic M, França K, Lotti T. Micro - Focused Phototherapy Associated To Janus Kinase Inhibitor: A Promising Valid Therapeutic Option for Patients with Localized Vitiligo. Open Access Maced J Med Sci [Internet]. 2018Jan.21 [cited 2020Oct.22];6(1):46-8. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2018.042

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