Sweet’s Syndrome (SS) in the Course of Acute Myeloid Leukaemia (AML)

  • Claudio Guarneri Universita degli Studi di Messina Clinical and Experimental Medicine, Section of Dermatology, Messina 98122
  • Uwe Wollina Städtisches Klinikum Dresden - Department of Dermatology and Allergology, Dresden, Sachsen
  • Torello Lotti University G. Marconi of Rome - Dermatology and Venereology, Rome
  • Georgi Konstantinov Maximov Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia
  • Ilia Lozev Medical Institute of Ministry of Interior, Department of General, Vascular and Abdominal Surgery, General Skobelev 79, 1606 Sofia
  • Serena Gianfaldoni University G. Marconi of Rome - Dermatology and Venereology, Rome
  • Ivan Pidakev Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia
  • Jacopo Lotti Department of Nuclear, Subnuclear and Radiation Physics, University of Rome "G. Marconi", Rome
  • Georgi Tchernev Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia; Onkoderma - Policlinic for Dermatology, Venereology and Dermatologic Surgery, General Skobelev 26, 1606, Sofia
Keywords: Sweet syndrome, Acute leukaemia, Complete response, Epirubicin

Abstract

Firstly described by Robert Douglas Sweet in 1964, febrile neutrophilic dermatosis is a disabling, not only cutaneous disorder, clinically characterised by fever and painful erythematous nodules, with a typical background of neutrophilia. Sweet’s syndrome (SS) is a chronic inflammatory reactive disorder of unknown cause and incompletely established pathogenesis, although an interplay between genetic and environmental factors, including infections, is likely to occur. A significant part of cases has been demonstrated to be linked with malignancies, especially in the hematologic setting. Because of the underlying disease and related therapeutic measures, SS may present atypical clinical course, whereas the response to treatment is strictly dependent on the concurrent hematologic disease. Herein we describe a case of a lady who had a refractory form of SS, resulted in a paraneoplastic cutaneous disease, and AML. Surprisingly, clinical remission of SS followed cytotoxic chemotherapy while hematologic disorder obtained a further complete response.

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References

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Published
2018-01-13
How to Cite
1.
Guarneri C, Wollina U, Lotti T, Maximov GK, Lozev I, Gianfaldoni S, Pidakev I, Lotti J, Tchernev G. Sweet’s Syndrome (SS) in the Course of Acute Myeloid Leukaemia (AML). Open Access Maced J Med Sci [Internet]. 2018Jan.13 [cited 2020Oct.22];6(1):105-7. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2018.006

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