Neglected Under Lip Cancer

  • Georgi Tchernev Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia; Onkoderma, Policlinic for Dermatology and Dermatologic Surgery, Sofia
  • Jose Carlos Cardoso Centro Hospitalar e Universitario de Coimbra EPE - Department of Dermatology and Venereology Coimbra, Coimbra
  • Ivan Pidakev Medical Institute of Ministry of Interior, Department of General, Vascular and Abdominal Surgery, General Skobelev 79, 1606 Sofia
  • Uwe Wollina Städtisches Klinikum Dresden - Department of Dermatology and Allergology, Dresden, Sachsen
  • Torello Lotti University G. Marconi of Rome - Dermatology and Venereology, Rome
  • Jacopo Lotti Department of Nuclear, Subnuclear and Radiation Physics, University of Rome "G. Marconi", Rome
  • Serena Gianfaldoni University G. Marconi of Rome - Dermatology and Venereology, Rome
  • Georgi Konstantinov Maximov Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia
  • Ilia Lozev Medical Institute of Ministry of Interior, Department of General, Vascular and Abdominal Surgery, General Skobelev 79, 1606 Sofia
Keywords: Lip cancer, Neglected, Chemotherapy, Surgery, Cetuximab

Abstract

The lip represents an anatomical area of the interface between the skin and oral mucosa. It is, therefore, not entirely surprising that SCC of the lip exhibits mixed features between cutaneous and oral mucosal SCC, namely regarding risk factors and biological behaviour. The main risk factors for lip SCC include ultraviolet radiation exposure, low phototype, tobacco and alcohol use, and immunosuppression. Lip SCC usually presents clinically as a nodule or a tumour with a keratotic surface that commonly ulcerates. There is often a background of actinic cheilitis. The particularly exuberant presentation of our case can most probably be explained by the long evolution of a tumour before the patient reached medical attention. Patients with regional lymph node metastasis are usually offered regional lymph node dissection (usually of the neck). Radiotherapy and/or chemotherapy may be used in advanced cases, particularly in unresectable tumours, tumours with high-risk features and metastatic disease. The large size of a tumour in our case, most probably due to its long evolution, highlights the importance of timely diagnosis to avoid such extreme presentations and the consequent need for more aggressive treatment.

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References

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Published
2018-01-13
How to Cite
1.
Tchernev G, Cardoso JC, Pidakev I, Wollina U, Lotti T, Lotti J, Gianfaldoni S, Maximov GK, Lozev I. Neglected Under Lip Cancer. Open Access Maced J Med Sci [Internet]. 2018Jan.13 [cited 2020Oct.30];6(1):87-8. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2018.005

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