Management, Diagnostic and Prognostic Significance of Acetylcholinesterase as a Biomarker of the Toxic Effects of Pesticides in People Occupationally Exposed

  • Mitar Lutovac University Nikola Tesla, Belgrade
  • Olga V. Popova Southern Federal University
  • Zoran Jovanovic High School Dositej Obradovic, Belgrade
  • Hatidza Berisa Military Academy, Belgrade
  • Radoman Kristina High Medical School, Podgorica
  • Sonja Ketin University of Novi Sad, Square Dositeja Obradovica 6, 21000, Novi Sad
  • Marko Bojic Privredna Akademija Novi Sad, Novi Sad
Keywords: Toxic effects, Pesticides, Organophosphorus compounds, Occupational exposure

Abstract

AIM: The paper presents research on the most common causes of exposure that leads to disorders of cholinesterase activity, as well as an overview of the results of cholinesterase activity with the poisoned people.

MATERIAL AND METHODS: In a group of 35 acute poisoned patients by organophosphate compounds has led to inhibition of AchE. A total number of examined workers are 175 in the chemical industry and agricultural production in the area of Rasina District-Serbia.

RESULTS: The results showed that among workers who are constantly exposed to pesticides, acetylcholinesterase is within the reference value. Having examined the medical records of these workers, it is noted that, at 72%, there is a slight fall of AchE activity, each year. The workers who had been exposed to pesticides at the time of testing had acetylcholinesterase regarding reference value, but 52% of them had a few years ago significantly reduced the value of the activity of acetylcholinesterase, which was treated and then transferred to other jobs. The 48% of these workers had acetylcholinesterase regarding benchmarks or were transferred to other jobs, for a variety of other health problems.

CONCLUSION: Using each pesticide should only deal with people who are well versed in the way of its use, as well as the way of protecting them from poisoning.

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References

Risher JF, De Rosa CT, Jones DE, Murray HE. Summary report for the expert panel review of the toxicological profile for mercury, Toxicol Ind Health. 1999; 15: 483 – 516. https://doi.org/10.1177/074823379901500504 PMid:10487360

Lauwerys RR, Hoet P. Industrial chemical Exposure: Guidelines for Biological Monitoring Boca Raton: Lewis Publisher, 1993.

Mertz W, Khan K, Long SG, et al. Symposium: Between a Rock and a Hard Place: Dietary and Toxicological Standards for Essential Minerals, New Orleans, 1997.

WHO Trace elements in human nutrition and health, Geneva, Switzerland, 1996.

Mertz W. J Nurt. 1998; 128: 712 – 7.

Vidakovic A. Professional toxicology. Belgrade: Association of Toxicologists of Yugoslavia, 2000.

Hulka BS. Overview of biological markers, in Biological Markers in Epidemiology, Hulka BS, Griffith JD, Wilcosky TC, Eds., Oxford University Press, New York, NY, USA, 1990: 3-15.

Naylor S. Biomarkers: current perspectives and future prospects. Expert Review of Molecular Diagnostics. 2003; 3(5):525–529. https://doi.org/10.1586/14737159.3.5.525 PMid:14510173

Manno M, Viau C, Cocker J, et al., Biomonitoring for occupational health risk assessment (BOHRA), Toxicology Letters. 2010; 192(1):3–16. https://doi.org/10.1016/j.toxlet.2009.05.001 PMid:19446015

Knudsen LE, Hansen ÅM. Biomarkers of intermediate endpoints in environmental and occupational health, International Journal of Hygiene and Environmental Health. 2007; 210(3- 4):461–470.

Majkic-Singh NT, Ignjatovic S, Kovacevic R, Ilic M, Lalic N. Prognostic significance of biomarkers. Yugoslav Medical Biochemistry. 2002; 21(1):1-8.

Gudenus, R. and Granzer, U.: Biomarker und Surrogatendpunkte. In: transkript. 7, 2010, S. 31-32.

Majkic-Singh N. Osteoporosis-The significance of clinical-biochemical parameters for detection and monitoring. Inpharm. 1997; 10: 11.

Chen JT, Hosoda K, Hasumi K, Ogata E, Shiraki M. Serum N-terminal osteocalcin is a good indicator for estimating responders to hormone replacement therapy in postmenopausal women. J Bone Min Res 1996; 11: 1784'92.

Ilic M, Majkic-Singh N. The importance of clinical, biochemical parameters for monitoring osteoporosis. Yugoslav Med Biohem. 1996; 15: 216.

Christenson RH, Azzary HME. Biochemical markers of the acute coronary syndromes. Clin Chem. 1998; 44: 1855-86. PMid:9702995

Majkic-Songh N. Biochemical parameters for the diagnosis of myocardial infarction. Infarm. 1998; 4:18-19.

Majkic-Singh N. New biochemical markers of myocardial damage. Jugoslov Med Biohem. 1999; 18(2-3): 63-70.

Ignjatovic S, Mirkovic D, Majkic-Singh N, Ignjatovic D. Phospholipase A, lipase, amylase and pancreatic amylase activity in taurocholate induced experimental acute necrotizing pancreatitis. Jugoslov Med Biohem. 1998; 17(2): 69-74.

Ignjatovic S, Majkic-Singh N, Mitrovic M, Gvozdenovic M. Biochemical evaluation of patients with acute pancreatitis. Clin Chem Lab Med. 2000; 38:1141-44. https://doi.org/10.1515/CCLM.2000.173 PMid:11156345

Majkic-Singh N. Metabolic changes and laboratory diagnosis of diabetes. Jugoslov Med Biohem. 1998; 17(1): 1-9.

Vessella LR, Lange P. Issues in the assessement of PSA imunoassays. The Urologic Clinics of North America. 1993; 20. 607-17. PMid:7505968

Maksimovic R. Clinical Biochemistry, Pharmacy and medical faculties Travnik, 2016.

Varagic V, Milosevic M, Pharmacology, 23.edition, Elit Medica, Beograd, 2009.

Barton L, Parker K, Blumenthal D, Buxton I, Goodman and Gilman's Manual of Pharmacology and Therapeutics, The McGraw Hill Companies, New York, 2008.

Katzung B, Masters S, Trevor A, Basic and clinical pharmacology, 12th Edition, The McGraw Hill Companies, New York, 2012.

Hartman DE. Missed diagnoses and misdiagnoses of environmental toxicant exposure. The psychiatry of toxic exposure and multiple chemical sensitivity. Psychiatr Clin North Am. 1998;21(3):659-70. https://doi.org/10.1016/S0193-953X(05)70030-7

Mikov M. Industrial Toxicology. Belgrade: Scientific Book, 1980.

Stankovic D. Occupational medicine. Beograd -Zagreb: Medical Book, 1986.

Stankovic M, Milic S. Analysis of biological material in industrial toxicology, Nis: Prosveta, 1970.

Published
2017-12-01
How to Cite
1.
Lutovac M, Popova OV, Jovanovic Z, Berisa H, Kristina R, Ketin S, Bojic M. Management, Diagnostic and Prognostic Significance of Acetylcholinesterase as a Biomarker of the Toxic Effects of Pesticides in People Occupationally Exposed. Open Access Maced J Med Sci [Internet]. 2017Dec.1 [cited 2020Oct.29];5(7):1021-7. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2017.200
Section
E - Public Health

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