Characteristic of the Oxidative Stress in Blood of Patients in Dependence of Community-Acquired Pneumonia Severity
BACKGROUND: At the present time the alternation of the oxidative metabolism is considered as one of the leading pathogenic mechanisms in the development and progression of community-acquired pneumonia (CAP). However the nature and direction of the oxidative protein changes in CAP patientâ€™s blood had been almost unexplored.
AIM: To define oxidative and modified proteins in erythrocytes and blood plasma of CAP patients.
MATERIAL AND METHODS: Blood plasma and erythrocytes obtained from: 42 patients with moderate severity pneumonia, 12 patients with grave severity pneumonia and 32 healthy volunteers. Content of advanced oxidation protein products, malondialdehyde and reactive carbonyl derivatives were estimated as indicators of the oxidative stress and oxidative damage of proteins.
RESULTS: In patients with grave severity the level of oxidative proteins and MDA in erythrocytes exceeded both: control values and similar meanings in CAP patients with moderate severity. The further growth of MDA in this group patientsâ€™ blood plasma was observed, but the level of oxidative proteins decreased in comparison with those in CAP patients with moderate severity.CONCLUSION: To sum up, our derived data show, that injury of erythrocytesâ€™ redox-status and blood plasma components plays an essential role in development and progression CAP.
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