Report on von Willebrand Disease in Malaysia
BACKGROUND: Von Willebrand disease (vWD) is an inherited hemostatic disorder that affects the hemostasis pathway. The worldwide prevalence of vWD is estimated to be 1% of the general population but only 0.002% in Malaysia.
AIM: Our present paper has been written to disclose the statistical counts on the number of vWD cases reported from 2011 to 2013.
MATERIAL AND METHODS: This article is based on sociodemographic data, diagnoses and laboratory findings of vWD in Malaysia. A total of 92 patients were reported to have vWD in Malaysia from 2011 to 2013.
RESULTS: Sociodemographic-analysis revealed that 60% were females, 63% were of the Malay ethnicity, 41.3% were in the 19-44 year old age group and 15.2% were from Sabah, with the East region having the highest registered number of vWD cases. In Malaysia, most patients are predominately affected by vWD type 1 (77.2%). Factor 8, von Willebrand factor: Antigen and vWF: Collagen-Binding was the strongest determinants in the laboratory profiles of vWD.CONCLUSION: This report has been done with great interest to provide an immense contribution from Malaysia, by revealing the statistical counts on vWD from 2011-2013.
Plum Analytics Artifact Widget Block
Moveforward "Health Care in Malaysia". Expatforum.com. Accessed via: http://en.academic.ru/dic.nsf/enwiki/11562. Accessed on February 25, 2014.
World health ranking website. Accessed via:
http://www.worldlifeexpectancy.com/country-health-profile/malaysia, 2014. Accessed on: March 10, 2014.
Pusat Darah Negara Website, 2012. Accessed via: http://translate.google.com.my/translate?hl=en&sl=ms&u=http://www.pdn.gov.my/&prev=/search%Fq%3Dpusat%2Bdarah%2Bnegara%26biw%3D1024%26bih%3D499. Accessed on March 10, 2014.
Tanushri M. von Willebrand disease: An overview. In book: National Hematology. Chapter: Von Willebrand disease, Publisher: Springer, Editors: Dr MB Agarwal. 2007;131-140.
Goodeve A, Eikenboom J, Castaman G, et al. Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 von Willebrand disease. (MCMDM-1VWD). Blood. 2007;109:112-121.
Kwa SB, Chan KY, Chan SK, et al. Haemophilia in Singapore. A study of the clinical and Haematological features in 36 patients. Sing Medic J. 1967;8(1):21-34.
Riley RS. von Willebrand Disease. 2005. Accessed via: http://www.pathology.vcu.edu/clinical/coag/vWD.pdf. Accessed on 23th March 2014.
Sadler JE, Budde U, Eikenboom JCJ, et al. Update on the pathophysiology and classification of von Willebrand disease: A report of the subcommittee on von Willebrand factor. J of Thromb & Haemost. 2006;4:2103â€“2114.
Practical-Hemostasis, A practical guide to laboratory hemostasis. 2012. Accessed via: http://practical-haemostasis.com/Factor%20Assays/VWF/vwf_assays_introduction.html. Accessed on 23th March 2014.
Branchford BR, Di Paola J. Making a diagnosis of VWD. Hematol Am Soc Hematol educ program. 2012;161-167.
The Diagnosis, Evaluation, and Management of von willebrand disease. U.S Department of Health and Human Services. National Institutes of Health. National Heart Lung and Blood Institute. NIH Publication No. 08-5832; 2007.
Laffan M, Brown SA, Collins PW, et al. The diagnosis of von Willebrand disease: a guideline from the UK Haemophilia Centre Doctors Organization. Haemophilia. 2004;10(3):199-217.
Keeney S, Bowen D, Cumming A, et al. The molecular analysis of von Willebrand disease: a guideline from the UK Haemophilia centre doctors organisation Haemophilia genetics laboratory network. Haemophilia. 2008;14(5):1099-1111.
Brandt JT. Laboratory Evaluation of Platelet Disorders. In McClatchey, K.D. Clinical Laboratory Medicine, 2nd Ed. Lippincott, Williams, and Wilkins; 2002.
Mohsin S, Aslam M, Hussain S, et al. Clinical manifestations and complications of von Willebrand disease. J Rawalpindi Med College. 2012;6(1):19-21.
All rights reserved.