Clinical Therapeutic Effects of the Application of Doxycycline in the Treatment of Periodontal Disease

  • Spiro Spasovski PHO „Fjolla Medika”, Skopje
  • Zlatanka Belazelkoska Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje
  • Mirjana Popovska Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje
  • Aneta Atanasovska-Stojanovska Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje
  • Vera Radojkova-Nikolovska Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje
  • Ilijana Muratovska Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje
  • Natasa Toseska-Spasova Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje
  • Biljana Dzipunova Faculty of Dentistry, Ss. Cyril and Methodius University of Skopje, 1000 Skopje
  • Bruno Nikolovski PHO ETERNAdent, Skopje
Keywords: periodontal disease, doxycycline, sub-dose, gingival inflammation, gingival bleeding

Abstract

OBJECTIVE: To compare the therapeutic effects of the application of doxycycline-full dose (100 mg) and sub-dose (20 mg) in the treatment of periodontal disease.

MATERIAL AND METHODS: A total of 60 patients with periodontal disease were examined. Patients are divided into two groups: A) treated with antimicrobial dose of 100 mg doxycycline once daily for 30 days, and B) treated with 2 x 20 mg/day. doxycycline, during 75 days. Among all patients a conservative treatment was carried out and ordinated the proper dose doxycycline in total dose during treatment from 3 gr. Index of dental plaque by Löe-Sillness, index of gingival inflammation and gingival bleeding by Cowell were followed.

RESULTS: Values of dental plaque in relation first examination, 10th, 20th day, 1 month and 2.5 months, showed that after 2.5 months, average value (x = 0.83) of dental plaque in second group is slightly less than the value (x = 0.93) of dental plaque in the first group. The average value (x = 0.17) of gingival inflammation in second group is significantly less than the value (x = 0.50) of gingival inflammation in the first group. The average value (x = 0.97) of gingival bleeding in patients from the first group was significantly higher than value(x = 0.37) of gingival bleeding in the second group.

CONCLUSION: Patients whose therapy was helped by a sub-dose doxycycline demonstrated positive therapeutic effects on gingival inflammation and bleeding.

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Published
2016-01-22
How to Cite
1.
Spasovski S, Belazelkoska Z, Popovska M, Atanasovska-Stojanovska A, Radojkova-Nikolovska V, Muratovska I, Toseska-Spasova N, Dzipunova B, Nikolovski B. Clinical Therapeutic Effects of the Application of Doxycycline in the Treatment of Periodontal Disease. Open Access Maced J Med Sci [Internet]. 2016Jan.22 [cited 2020Dec.2];4(1):152-7. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2016.021
Section
D - Dental Sciences

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