Maternal and Neonatal Effects of Vasopressors Used for Treating Hypotension after Spinal Anesthesia for Caesarean Section: A Randomized Controlled Study

  • Alma Soxhuku-Isufi University Hospital of Obstetrics and Gynecology "Koço Gliozheni", Tirana
  • Vjollca Shpata Faculty of Technical Medical Sciences, University of Medicine in Tirana, Tirana
  • Hektor Sula Faculty Medicine, University of Medicine in Tirana, Tirana
Keywords: ephedrine, caesarean section, hypotension, maternal, neonatal outcome, phenylephrine

Abstract

AIM: The aim of the study was to examine whether ephedrine and phenylephrine were different in their efficacy for managing maternal hypotension and their effect of adverse maternal and neonatal outcome.

METHODS: A double-blind randomized controlled study in healthy pregnant women ASA physical status 2, which underwent elective caesarian delivery under spinal anesthesia. Patients were randomized to receive an intravenous bolus of either phenylephrine (Ph group) or ephedrine (E group) immediately after the episode of hypotension after spinal anesthesia. Maternal and neonatal outcomes were recorded.

RESULTS: Two hundred and two (202) pregnant women at term were entered in this study. There were no differences between group E and group Ph regarding the incidence of hypotension after vasopressor therapy, and the incidence of nausea and vomiting. There was no significant difference between groups in the first-minute and the 5th minute Apgar score, none of the neonates had the true fetal acidosis.

CONCLUSIONS: Ephedrine and phenylephrine have the same efficacy in treating hypotension after spinal anesthesia for caesarean section. The use of Phenylephrine was associated with better fetal acid-base status, and there were no differences on Apgar score values and on the incidence of maternal bradycardia and hypotension.

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Published
2015-12-25
How to Cite
1.
Soxhuku-Isufi A, Shpata V, Sula H. Maternal and Neonatal Effects of Vasopressors Used for Treating Hypotension after Spinal Anesthesia for Caesarean Section: A Randomized Controlled Study. Open Access Maced J Med Sci [Internet]. 2015Dec.25 [cited 2020Nov.29];4(1):54-8. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2016.003
Section
B - Clinical Sciences