Assessment of the Level of GABA and Some Trace Elements in Blood in Children who Suffer from Familial Febrile Convulsions

  • Osama N. Salah Ain Shams University - Pediatrics, Cairo
  • Ehab R. Abdelraouf National Research Center - Research on Children with Special Needs Department, Giza, Cairo
  • Marwa H. Abdelhameed Ain Shams University - Pediatrics, Cairo
  • Ahmed A. Dawood National Research Center - Research on Children with Special Needs Department, Giza, Cairo
  • Adel F. Hashish National Research Center - Research on Children with Special Needs Department, Giza, Cairo
  • Ayman Kilany National Research Center - Research on Children with Special Needs Department, Giza, Cairo
  • Suzette I. Helal National Research Center - Research on Children with Special Needs Department, Giza, Cairo
Keywords: Febrile convulsions, trace elements, GABA, Egyptian children.

Abstract

Febrile seizure is one of the most common neurological problems during childhood. The etiology and pathogenesis of febrile seizure remain unknown. However, several factors such as vitamin B6 deficiency, electrolyte disturbances, and reduction in serum zinc, selenium, magnesium levels, and low gamma - aminobutyric acid (GABA) levels are thought to play a role in the pathogenesis of febrile seizure. The present study included twenty children from 10 families, 11 were male and 9 were female. Each family has at least 2 members with a history of febrile convulsion. All cases were subjected to the following: Determination of serum levels of copper, zinc, magnesium, selenium level in serum, and plasma level of γ-aminobytaric acid (GABA). Serum levels of selenium and GABA were statistically significantly low in comparison with controls. Serum copper was statistically significantly higher in cases than controls, while serum zinc showed no significant changes in the cases of febrile convulsion compared with the control group. The mean Zn level in the serum of febrile convulsion was found to be at lower level than in the control group. The serum magnesium was significantly low in cases than controls. The logistic regression model in our study shows that Selenium and Magnesium have protective effects, while Copper has causative effect.

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Published
2014-03-15
How to Cite
1.
Salah ON, Abdelraouf ER, Abdelhameed MH, Dawood AA, Hashish AF, Kilany A, Helal SI. Assessment of the Level of GABA and Some Trace Elements in Blood in Children who Suffer from Familial Febrile Convulsions. Open Access Maced J Med Sci [Internet]. 2014Mar.15 [cited 2021Jan.18];2(1):68-3. Available from: https://www.id-press.eu/mjms/article/view/78
Section
B - Clinical Sciences