Gastrointestinal Aspects of COVID-19: A Review

  • Gontar Alamsyah Siregar Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Ginanda Putra Siregar Department of Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Darmadi Darmadi Division of Gastroenterohepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Keywords: covid-19, Gastrointestinal, SARS-CoV-2


Coronaviruses commonly cause mild infections, but recently severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 caused a pandemic of coronavirus disease 2019 (COVID-19). A total of 3,181,642 cases were confirmed globally. Gastrointestinal tract may be involved in COVID-19 due to the presence of angiotensin converting enzyme-2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) in small intestine and colon which are mandatory for SARS-CoV-2 invasion. A proportion of patients with COVID-19 had gastrointestinal manifestation without respiratory symptoms. Viable virus can also be isolated from feces of patients. Fecal-oral transmission should be considered in controlling disease spreading. Fecal examination may also be considered to diagnose COVID-19, especially in areas with limited personal protective equipment.


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How to Cite
Siregar GA, Siregar GP, Darmadi D. Gastrointestinal Aspects of COVID-19: A Review. Open Access Maced J Med Sci [Internet]. 2020Jun.20 [cited 2020Sep.30];8(T1):52-4. Available from:

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