Coronavirus Disease-19 and Cardiovascular Disease

  • Irena Mitevska University Cardiology Clinic, Skopje, Republic of Macedonia
  • Lidija Poposka University Cardiology Clinic, Skopje, Republic of Macedonia
Keywords: Coronavirus disease-19, Pandemic, Myocardial injury, Cardiovascular disease


 We are facing serious coronavirus disease-19 pandemic, caused by the severe acute respiratory syndrome coronavirus-2. Among infected individuals, there is a higher prevalence of the cardiovascular disease, which leads to their poor prognosis. Myocardial injury is present in more than 15% of critical ill patients in the form of acute myocardial dysfunction or subsequent myocardial injury that develops as disease severity. This new virus pandemic is a global challenge for health-care system which was we still have much to learn.


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Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese center for disease control and prevention. JAMA. 2020;323(13):1239-1242. PMid:32091533

Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-3. PMid:32015507

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet. 2020;395(10223):507- 13. PMid:32007143

Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. The proximal origin of SARS-CoV-2. Nat Med. 2020;26(4):450-2. PMid:32284615

Zheng YY, Ma YT, Zhang JY, Xie X. COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020;17(5):259-60. PMid:32139904

Wu JT, Leung K, Bushman M, Kishore N, Niehus R, de Salazar PM, et al. Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China. Nat Med. 2020;26(4):506-10. PMid:32284616

Coronavirus Disease 2019 (COVID-19): Diagnosis and Management (Narrative Review). Erciyes Med J 2020; 42(3); 1-6.

Zhou F, Yu T, Du R. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020;395(10229):1054- 62. PMid:32171076

Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382:1708-20.

Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: Estimation and application. Ann Intern Med. 2020;172(9):577-82. PMid:32150748

Van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, et al. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med. 2020;382(16):1564- 7. PMid:32182409

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.

Liu Z, Bing X, Zh XZ. Novel coronavirus pneumonia emergency response epidemiology team. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41(2):145-51. PMid:32064853

Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 2005;11(8):875-79. PMid:16007097

Han Y. Initial COVID-19 affecting cardiac patients in China. Eur Heart J. 2020;41(18):1719. PMid:32232395

Hu H, Ma F, Wei X, Fang Y. Coronavirus fulminant myocarditis saved with glucocorticoid and human immunoglobulin. Eur Heart J. 2020;2020:1249-50. PMid:32176300

Zeng JH, Liu YX, Yuan J, Wang FX, Wu WB, Li JX, et al. First case of COVID-19 infection with fulminant myocarditis complication: Case report and insights. Infection. 2020; 2020:1-5. PMid:32277408

Hanley B, Lucas SB, Youd E, Swift B, Osborn M. Autopsy in suspected COVID-19 cases. J Clin Pathol. 2020;73(5):239-42. PMid:32198191

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. PMid:32031570

He XW, Lai JS, Cheng J, Wang MW, Liu YJ, Xiao ZC, etal. Impact of complicated myocardial injury on the clinical outcome of severe or critically ill COVID-19 patients. Zhonghua Xin Xue Guan Bing Za Zhi. 2020;48:E011. PMid:32171190

Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, et al. Association of cardiac injury with mortality in hospitalized patients with COVID- 19 in Wuhan, China. JAMA Cardiol. 2020;2020:e200950. PMid:32211816

Liua KC, Xub P, Lvc WF, Yao JL, Gu JF, Wei W, et al. CT manifestations of coronavirus disease-2019: A retrospective analysis of 73 cases by disease severity. Eur J Radiol. 2020;126:108941.

Mehra MR, Ruschitzka F. COVID-19 illness and heart failure: A missing link? JACC Heart Fail. 2020;8(6):512-4. PMid:32360242

Han Y, Zeng H, Jiang H, Yang Y, Yuan Z, Cheng X, et al. CSC expert consensus on principles of clinical management of patients with severe emergent cardiovascular diseases during the COVID-19 epidemic. Circulation. 2020;141(20):e810- 6. PMid:32216640

Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB. Pharmacologic treatments for coronavirus disease 2019 (COVID-19): A review. JAMA. 2020;323(18):1824-36. PMid:32282022

Xiong TY, Redwood S, Prendergast B, Chen M. Coronaviruses and the cardiovascular system: Acute and long-term implications. Eur Heart J. 2020;41(19):1798- 800. PMid:32186331

ACC Clinical Bulletin Focuses on Cardiac Implications of Coronavirus (COVID-19). Available from: ncov. [Last accessed on 2020 Apr 15].

ASE Statement on Protection of Patients and Echocardiography Service Providers During the 2019 Novel Coronavirus Outbreak. Available from: uploads/2020/03/COVIDStatementFINAL4-1-2020_v2_ website.pdf. [Last accessed on 2020 Apr 15].

Ohad O, Kopecky SL, Gluckman TJ, Gersh BJ, Blumenthal RS. Coronavirus Disease 2019 (COVID-19): Epidemiology, Clinical Spectrum and Implications for the Cardiovascular Clinician. Available from: https://www.acc. org/latest-in-cardiology/articles/2020/04/06/11/08/covid-19- epidemiology-clinical-spectrum-and-implications-for-the-cv-clinician. [Last accessed on 2020 Apr 10]. https://doi. org/10.4103/2543-1463.282193

How to Cite
Mitevska I, Poposka L. Coronavirus Disease-19 and Cardiovascular Disease. Open Access Maced J Med Sci [Internet]. 2020Jun.15 [cited 2020Sep.30];8(T1):39-4. Available from: