The Role of Serum Neutrophil Gelatinase-associated Lipocalin in the Early Diagnosis of Nephropathy in Patients with Acute Alcohol Poisoning

  • L. Demidchik Department of Fundamental Medicine, Biological Chemistry, Karaganda Medical University, Kazakhstan
  • D. Klyuyev Department of Fundamental Medicine, Biological Chemistry, Karaganda Medical University, Kazakhstan
  • L. Muravlyova Department of Fundamental Medicine, Biological Chemistry, Karaganda Medical University, Kazakhstan
  • V. Molotov-Luchanskiy Department of Fundamental Medicine, Karaganda Medical University, Kazakhstan
  • R. Bakirova Department of Internal Diseases, Karaganda Medical University, Kazakhstan
Keywords: neutrophil gelatinase-associated lipocalin, NGAL, acute alcohol poisoning, nephropathy, kidney damage

Abstract

AIM: In our study, we assessed the possibility of using the serum neutrophil gelatinase-associated lipocalin (NGAL) for the early detection of kidney damage in patients with acute alcohol poisoning (AAP).

METHODS: The study included 89 patients and 30 healthy donors. All participants in the study were mostly represented by men (90%) aged between 20 and 40 years. The influence of alcohol poisoning severity was also taken into account in the study. The Human NGAL ELISA Kit was used for the quantitative detection of serum NGAL. We also evaluated the main laboratory indicators of kidney functions, including eGFR (calculated according to serum creatinine).

RESULTS: We did not find a correlation between blood alcohol concentration and serum NGAL level; also, alcohol poisoning severity did not affect the NGAL values. The results of our study showed the possibility of using the serum NGAL in patients with AAP to detect the preclinical stage of reduced renal function, until the moment when it can be diagnosed with using only serum creatinine.

CONCLUSION: We propose to consider an increase in eGFR together with an increase in serum NGAL in this group of patients as a stage, preceding nephropathy, even in the absence of clinical and laboratory signs of impaired renal function.

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References

Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair- Rohani H, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2224- 60. https://doi.org/10.3410/f.719894684.793533485 PMid:23245609

Nashkenova A, Zhamalieva D, Zholaushybekova A. Alcoholism in Kazakhstan (statistical data analysis)]. Vestnik KazNMU. 2015;2:201-5. Available from: https://www.cyberleninka.ru/ article/n/rasprostranyonnost-alkogolizma-v-kazahstane-obzor-i-interpretatsiya-statisticheskih-dannyh. [Last accessed on 2019 Jul 10].

Eskalieva AT, Kisina MS, Kuderina LT. Drug Addiction Treatment to the Population of the Republic of Kazakhstan. Statistical Book for 2013-2014. Republican Scientific and Practical Center of Medical and Social Problems of Drug Addiction. Geneva, Switzerland: UNAIDS; 2015. p. 25.

Kraeva Yu V, Brusin KM, Kondrashov DL, Sentsov VG, Hovda KE. Pre-hospital and hospital acute poisoning pattern study. Biomed J Med 2013;14:750-61.

Babanin AA, Belovitsky OV, Skrebkova OY, Sherbakova VM. Current understanding about the damages of the kidneys in alcoholic intoxication (literature review). Crimea J Exp Clin Med 2011;1:150-4.

Vereschagina TD. Classification of secondary nephropathies and chronic kidney disease (CKD). Siber Med Rev. 2012;1(73):100-3. Available from: https://www.cyberleninka. ru/article/n/k-voprosu-o-klassifikatsii-vtorichnyh-nefropatiy-i-hronicheskoy-bolezni-pochek-hbp. [Last accessed on 2019 Jul 01].

Shlipak MG, Katz R, Sarnak MJ, Fried LF, Newman AB, Stehman-Breen C, et al. Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease. Ann Intern Med. 2006;145(4):237-46. https://doi.org/10.7326/0003-4819-145-4-200608150-00003 PMid:16908914

Vel’kov VV. Cystatin C and NGAL the markers of preclinical renal dysfunction and subclinical acute kidney injury. Lab Sluzhba. 2015;4(2):38-43. Available from: https://www.mediasphera.ru/ issues/laboratornaya-sluzhba/2015/2/032305-2198201526. [Last accessed on 2019 Jul 05]. https://doi.org/10.17116/ labs20154238-43

Peralta CA, Katz R, Sarnak MJ, Ix J, Fried LF, De Boer I, et al. Cystatin C identifies chronic kidney disease patients at higher risk for complications. J Am Soc Nephrol. 2011;22(1):147-55. https://doi.org/10.1681/asn.2010050483 PMid:21164029

Woo KS, Choi JL, Kim BR, Kim JE, An WS, Han JY. Urinary neutrophil gelatinase-associated lipocalin levels in comparison with glomerular filtration rate for evaluation of renal function in patients with diabetic chronic kidney disease. Diabetes Metab J. 2012;36(4):307-13. https://doi.org/10.4093/dmj.2012.36.4.307 PMid:22950063

Markova TN, Sadovskaya VV, Bespyatova MY. Modern methods of diagnosing chronic kidney disease in patients with diabetes mellitus. Diabetes Mellitus. 2017;20(6):454-60. Available from: https://www.endojournals.ru/index.php/dia/article/view/9268/0. [Last accessed on 2019 Jul 05]. https://doi.org/10.14341/ dm9268

Haase-Fielitz A, Haase M, Devarajan P. Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury: A critical evaluation of current status. Ann Clin Biochem. 2014;51(Part 3):335-51. https://doi.org/10.1177/0004563214521795 PMid:24518531

Haase M, Bellomo R, Devarajan P, Ma Q, Bennett MR. Novel biomarkers early predict the severity of acute kidney injury after cardiac surgery in adults. Ann Thorac Surg 2009;88(1):124-30. https://doi.org/10.1016/j.athoracsur.2009.04.023 PMid:19559209

Hawkins R. New biomarkers of acute kidney injury and the cardio-renal syndrome. Korean J Lab Med. 2011;31(2):72-80. https://doi.org/10.3343/kjlm.2011.31.2.72 PMid:21474979

Doi K, Yuen PS, Eisner C, Hu X, Leelahavanichkul A, Schnermann J, et al. Reduced production of creatinine limits its use as marker of kidney injury in sepsis. J Am Soc Nephrol. 2009;20(6):1217-21. https://doi.org/10.1681/asn.2008060617 PMid:19389851

Mehta RL. Biomarker explorations in acute kidney injury: The journey continues. Kidney Int. 2011;80(4):332-34. https://doi. org/10.1038/ki.2011.181 PMid:21799504

Iaiu P, Saganova ES, Smirnov AV. Biomarkers in the diagnosis of acute kidney injury. Nephrology (Saint-Petersburg). 2014;18(4):25-35. Available from: https://www.cyberleninka. ru/article/n/biomarkery-v-diagnostike-ostrogo-povrezhdeniya-pochek-soobschenie-i. [Last accessed on 2019 Jul 10].

Luzhnikov EA, Kostomarova LG. Acute Poisoning: A Guide for Doctors. Moscow: Medicine; 1989.

Ostermann M, Joannidis M. Acute kidney injury 2016: Diagnosis and diagnostic workup. Crit Care. 2016;20(1):299. https://doi. org/10.1186/s13054-016-1478-z PMid:27670788

McDonald JH. Handbook of Biological Statistics. 3rd ed. Baltimore, Maryland, USA: Sparky House Publishing; 2014. p. 146-8.

Grjibovsky АМ. Analysis of three and more independent groups of quantitative data. Hum Ecol J. 2008;(3):50-8. Available from: https://www.cyberleninka.ru/article/n/analiz-treh-i-bolee-nezavisimyh-grupp-kolichestvennyh-dannyh. [Last accessed on 2019 Jul 02].

Kursov SV, Mikhnevich KG, Krivobok VI. Acute poisoning with ethanol. Med Emerg States. 2012;7-8(46-47):22-35. Available from: https://www.cyberleninka.ru/article/n/ostroe-otravlenie-etanolom. [Last accessed on 2019 Jul 01].

Zelveian PH, 2, Dheryan LG. Glomerular filtration rate as a marker of kidney damage in patients with arterial hypertension. Eur Heart J. 2014;(2):44-8. Available from: https://www. cyberleninka.ru/article/n/skorost-klubochkovoy-filtratsii-kak-pokazatel-porazheniya-pochek-u-bolnyh-s-arterialnoy-gipertenziey. [Last Accessed on 2019 Jul 02].

Lopez-Novoa JM, Rodriguez-Pena AB, Ortiz A, Martinez- Salgado C, Lopez Hernandez FJ. Etiopathology of chronic tubular, glomerular and renovascular nephropathies: Clinical implications. J Transl Med. 2011;9:13. https://doi. org/10.1186/1479-5876-9-13 PMid:21251296

Published
2020-05-15
How to Cite
1.
Demidchik L, Klyuyev D, Muravlyova L, Molotov-Luchanskiy V, Bakirova R. The Role of Serum Neutrophil Gelatinase-associated Lipocalin in the Early Diagnosis of Nephropathy in Patients with Acute Alcohol Poisoning. Open Access Maced J Med Sci [Internet]. 2020May15 [cited 2020Oct.23];8(B):548-52. Available from: https://www.id-press.eu/mjms/article/view/3346