The use of Cinnamon (Cinnamomum Bark) for Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Randomized Controlled Trial

  • Harth Mohamed Kamber Department of Surgery, Division of Urology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
  • Tawfiq Jasim Mohammed Al-Marzooq Department of Surgery, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
  • Malath Anwar Hussein Department of Surgery, Division of Urology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
  • Qays Ahmed Hassan Department of Surgery, Division of Radiology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
  • Ahmed Abid Marzouq Department of Community medicine, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
Keywords: Chronic prostatitis/chronic pelvic pain syndrome, Cinnamon, Herbal medicine, Traditional medicine

Abstract

BACKGROUND: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is common, yet no curative treatment identified. Cinnamon is a herbal substance, which has many applications in medicine.

AIM: The aim of the study was to study the effect of cinnamon on patients with chronic pelvic pain syndrome.

METHODS: Sixty patients with documented CP/CPPS randomized into two groups during 2018 and 2019 in Baghdad. The first group received 60 capsules each contained 1 g of cinnamon. The other group received 60 capsules each contained 1 g of sugar powder (placebo). All the patients instructed to take one capsule twice daily for 1 month. National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) was reported for both groups at baseline and after 1 month of treatment. The primary outcome was a patient perceivable improvement defined as a reduction of the NIH-CPSI by 6 or more points after 1 month, whereas improvement of sub-scores of NIH-CPSI (pain, urinary symptoms, and quality of life) considered as a secondary outcome, and adverse reactions reported.

RESULTS: Thirteen patients (43.3%) of the cinnamon group have 6 or more points of reduction in the total NIH-CPSI compared to four patients (13.3%) of the control groups (p = 0.01). The improvement in total NIH-CPSI score was mainly due to improvement in pain sub-score, whereas in urinary symptoms, there was marginal change with no significant change in the quality of life score. The only reported side effect was gastric upset in one patient.

CONCLUSION: The study concluded that cinnamon improves NIH-CPSI in patients with CP/CPPS.

REGISTRATION: The study was registered on ClinicalTrials.gov with the ID: NCT03946163.

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References

Magistro G, Nickel J. Evaluation of chronic prostatitis/chronic pelvic pain syndrome. 2019;10:295-301. PMid:19570491

Krieger JN, Nyberg L Jr., Nickel JC. NIH consensus definition and classification of prostatitis. JAMA. 1999;282(3):236-7. https://doi.org/10.1001/jama.282.3.236 PMid:10422990

DeWitt-Foy ME, Nickel JC, Shoskes DA. Management of chronic prostatitis/chronic pelvic pain syndrome. Eur Urol Focus. 2019;5(1):2-4. https://doi.org/10.1016/j.euf.2018.08.027 PMid:30206001

Krieger JN, Lee SW, Jeon J, Cheah PY, Liong ML, Riley DE. Epidemiology of prostatitis. Int J Antimicrob Agents. 2008;31(Suppl 1):85-90. https://doi.org/10.1016/j. ijantimicag.2007.08.028 PMid:18164907

Nickel JC. Prostatitis: Myths and realities. Urology. 1998;51(3):362- 6. https://doi.org/10.1016/s0090-4295(97)00643-2 PMid:9510337

Lee SW. Recent trend of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) management. Hanyang Med Rev. 2017;37(1):40-6. https://doi.org/10.7599/hmr.2017.37.1.40

Hasan HF. The use of tadalafilin patients with chronic prostatitis/ chronic pelvic pain syndrome. Iraqi J Med Sci. 2013;11(1):78-83.

Hempen CH, Fischer T. A MATERIA Medica for Chinese Medicine: Plants, Minerals, and Animal Products. Amsterdam, Netherlands: Elsevier Health Sciences; 2009.

Nabavi S, Di Lorenzo A, Izadi M, Sobarzo-Sánchez E, Daglia M. Antibacterial effects of cinnamon: From farm to food, cosmetic and pharmaceutical industries. Nutrients. 2015;7(9):7729-48. https://doi.org/10.3390/nu7095359 PMid:26378575

Chen P, Sun J, Ford P. Differentiation of the four major species of cinnamons (C. burmannii, C. verum, C. cassia, and C. loureiroi) using a flow injection mass spectrometric (FIMS) fingerprinting method. J Agric Food Chem. 2014;62(12):2516-21. https://doi. org/10.1021/jf405580c PMid:24628250

Senanayake UM, Lee TH, Wills RB. Volatile constituents of cinnamon (Cinnamomum zeylanicum) oils. J Agric Food Chem. 1978;26(4):822-4. https://doi.org/10.1021/jf60218a031

Tung YT, Chua MT, Wang SY, Chang ST. Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs. Bioresour Technol. 2008;99(9):3908-13. https://doi.org/10.1016/j. biortech.2007.07.050 PMid:17826984

Tung YT, Yen PL, Lin CY, Chang ST. Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves. Pharm Biol. 2010;48(10):1130-6. https:// doi.org/10.3109/13880200903527728 PMid:20815702

Rao PV, Gan SH. Cinnamon: A multifaceted medicinal plant. Evid Based Complement Altern Med. 2014;2014:642942. https://doi.org/10.1155/2014/642942 PMid:24817901

Al-Ani RA, Adhab MA, Nawar HH. Antibacterial activity of clove, cinnamon, and datura extracts against Erwinia carotovora subsp. atroseptica causative agent of black stem and soft rot on potato. J Med Plants Res. 2012;6(10):1891-5.

Al-dhaher ZA. The antibacterial activity of aqueous extract of cinnamon and clove against Staphylococcus aureus. Al-Nahrain J Sci. 2008;11(2):131-5. https://doi.org/10.22401/jnus.11.2.19

Jaafarpour M, Hatefi M, Khani A, Khajavikhan J. Comparative effect of cinnamon and Ibuprofen for treatment of primary dysmenorrhea: A randomized double-blind clinical trial. J Clin Diagn Res. 2015;9(4):QC04. https://doi.org/10.7860/ jcdr/2015/12084.5783 PMid:26023601

Mohammadi A, Mohammad-Alizadeh-Charandabi S, Mirghafourvand M, Javadzadeh Y, Fardiazar Z, Effati- Daryani F. Effects of cinnamon on perineal pain and healing of episiotomy: A randomized placebo-controlled trial. J Integr Med. 2014;12(4):359-66. https://doi.org/10.1016/ s2095-4964(14)60025-x PMid:25074885

Litwin MS, McNaughton-Collins M, Fowler FJ, Nickel JC, Calhoun EA, Pontari MA, et al. The National Institutes of Health chronic prostatitis symptom index: Development and validation of a new outcome measure. J Urol. 1999;162(2):369-75. https:// doi.org/10.1016/s0022-5347(05)68562-x PMid:10411041

Propert KJ, Litwin M, Wang Y, Alexander RB, Calhoun E, Nickel JC, et al. Responsiveness of the national institutes of health chronic prostatitis symptom index (NIH-CPSI). Qual Life Res. 2006;15(2):299-305. https://doi.org/10.1007/ s11136-005-1317-1 PMid:16468084

El-Nashaar A, Fathy A, Zeedan A, Al-Ahwany A, Shamloul R. Validity and reliability of the arabic version of the national institutes of health chronic prostatitis symptom index. Urol Int. 2006;77(3):227-31. https://doi.org/10.1159/000094814 PMid:17033210

Browne RH. On the use of a pilot sample for sample size determination. Stat Med. 1995;14(17):1933-40. PMid:8532986

Julious SA. Sample size of 12 per group rule of thumb for a pilot study. Pharm Stat. 2005;4(4):287-91.

Pontari MA, Ruggieri MR. Mechanisms in prostatitis/chronic pelvic pain syndrome. J Urol. 2008;179(5):S61-7. https://doi. org/10.1016/j.juro.2008.03.139 PMid:18405756

Kouiavskaia DV, Southwood S, Berard CA, Klyushnenkova EN, Alexander RB. T-cell recognition of prostatic peptides in men with chronic prostatitis/chronic pelvic pain syndrome. J Urol. 2009;182(5):2483-9. https://doi.org/10.1016/j.juro.2009.07.067 PMid:19765754

Jahangirifar M, Taebi M, Dolatian M. The effect of Cinnamon on primary dysmenorrhea: A randomized, double-blind clinical trial. Complementary therapies in clinical practice. 2018;33:56-60. https://doi.org/10.1016/j.ctcp.2018.08.001 PMid:30396627

Jaafarpour M, Hatefi M, Najafi F, Khajavikhan J, Khani A. The effect of cinnamon on menstrual bleeding and systemic symptoms with primary dysmenorrhea. Iran Red Crescent Med J. 2015;17(4):e27032. https://doi.org/10.5812/ircmj.17(4)2015.27032 PMid:26023350

Dashti RM, Qane MD, Shefaie F, Nazemian Yazdu M, Bagheri SM. Comparative effect of cinnamon essential oil, diclofenac and morphine on acute and chronic pain in mice. Int J Med Lab. 2016;3(2):92-103.

Dashti-Rahmatabadi M, Merjardi AV, Pilavaran A, Farzan F. Antinociceptive effect of cinnamon extract on formalin induced pain in rat. SSU J. 2009;17(2):190-9.

Nagai H, Shimazawa T, Matsuura N, Koda A. Immunopharmacological studies of the aqueous extract of Cinnamomum cassia (CCAq) I. anti-allergic action. Jpn J Pharmacol. 1982;32(5):813-22. https://doi.org/10.1254/ jjp.32.813 PMid:7176217

Shen Y, Jia LN, Honma N, Hosono T, Ariga T, Seki T. Beneficial effects of cinnamon on the metabolic syndrome, inflammation, and pain, and mechanisms underlying these effects a review. J Tradit Complement Med. 2012;2(1):27-32. https://doi. org/10.1016/s2225-4110(16)30067-0 PMid:24716111

Shobana S, Naidu KA. Antioxidant activity of selected Indian spices. Prostaglandins Leukot Essent Fatty Acids. 2000;62(2):107-10. https://doi.org/10.1054/plef.1999.0128 PMid:10780875

Dragland S, Senoo H, Wake K, Holte K, Blomhoff R. Several culinary and medicinal herbs are important sources of dietary antioxidants. J Nutr. 2003;133(5):1286-90. https://doi. org/10.1093/jn/133.5.1286 PMid:12730411

Chericoni S, Prieto JM, Iacopini P, Cioni P, Morelli I. In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes. J Agric Food Chem. 2005;53(12):4762-5. PMid:15941312

Mancini-Filho J, Van-Koiij A, Mancini D, Cozzolino F, Torres R. Antioxidant activity of cinnamon (Cinnamomum zeylanicum, Breyne) extracts. Boll Chim Farm. 1998;137(11):443-7. PMid:10077878

Okawa M, Kinjo J, Nohara T, Ono M. DPPH (1, 1-diphenyl-2- picrylhydrazyl) radical scavenging activity of flavonoids obtained from some medicinal plants. Biol Pharm Bull. 2001;24(10):1202- 5. https://doi.org/10.1248/bpb.24.1202 PMid:11642334.

Iwasaki Y, Tanabe M, Kobata K, Watanabe T. TRPA1 agonists allyl isothiocyanate and cinnamaldehyde induce adrenaline secretion. Biosci Biotechnol Biochem. 2008;72(10):2608-14. https://doi.org/10.1271/bbb.80289 PMid:18838811.

Bahmani M, Shirzad H, Majlesi M, Shahinfard N, Rafieian-Kopaei M. A review study on analgesic applications of Iranian medicinal plants. Asian Pac J Trop Med. 2014;7:S43- S53. https://doi.org/10.1016/s1995-7645(14)60202-9 PMid:25312163.

Herati AS, Shorter B, Srinivasan AK, Tai J, Seideman C, Lesser M, et al. Effects of foods and beverages on the symptoms of chronic prostatitis/chronic pelvic pain syndrome. Urology. 2013;82(6):1376-80. https://doi.org/10.1016/j. urology.2013.07.015 PMid:23978369.

Tripp DA, Nickel JC, Landis JR, Wang YL, Knauss JS, Group CS. Predictors of quality of life and pain in chronic prostatitis/chronic pelvic pain syndrome: Findings from the national institutes of health chronic prostatitis cohort study. BJU Int. 2004;94(9):1279- 82. https://doi.org/10.1111/j.1464-410x.2004.05157.x PMid:15610105.

Hajimonfarednejad M, Ostovar M, Raee MJ, Hashempur MH, Mayer JG, Heydari M. Cinnamon: A systematic review of adverse events. Clin Nutr. 2019;38(2):594-602. https://doi. org/10.1016/j.clnu.2018.03.013 PMid:29661513.

Published
2020-08-05
How to Cite
1.
Kamber HM, Al-Marzooq TJM, Hussein MA, Hassan QA, Marzouq AA. The use of Cinnamon (Cinnamomum Bark) for Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Randomized Controlled Trial. Open Access Maced J Med Sci [Internet]. 2020Aug.5 [cited 2020Oct.31];8(B):439-45. Available from: https://www.id-press.eu/mjms/article/view/3311