Epidermoid Cysts – A Wide Spectrum of Clinical Presentation and Successful Treatment by Surgery: A Retrospective 10-Year Analysis and Literature Review

  • Uwe Wollina Städtisches Klinikum Dresden, Department of Dermatology and Allergology, 01067 Dresden
  • Dana Langner Stadtisches Klinikum Dresden - Department of Dermatology and Allergology, Dresden, Sachsen
  • Georgi Tchernev Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior, Sofia; Onkoderma Policlinic for Dermatology and Dermatologic Surgery, Sofia
  • Katlein França Department of Dermatology and Cutaneous Surgery, Department of Psychiatry & Behavioral Sciences; Institute for Bioethics and Health Policy, University of Miami Miller School of Medicine, Miami, FL
  • Torello Lotti University of Rome G. Marconi, Institute of Dermatology, Rome 00186
Keywords: Epidermoid cysts, Pathogenesis, Skin, Surgery, Gardner syndrome, Lowe syndrome

Abstract

Epidermoid cysts are common benign lesions of hair-bearing, and less often glabrous skin. They can also occur in oral mucosa and internal organs. In case of cutaneous lesions, an epidermal punctum is a clinical diagnostic hallmark. The clinical presentation is variable leading to some differential diagnoses. Diagnosis of epidermoid cysts needs histopathological confirmation – not only of the potential of malignant transformation. The treatment of choice is surgery. We report a retrospective analysis of 2159 epidermoid cysts treated surgically. Most of the cases can be performed under local anaesthesia. The complication rate of 2.2% is low. To avoid relapses, the cyst wall has to be removed completely. Rare genetic disorders with multiple cysts are Gardner and Lowe syndrome.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Plewig G, Landthaler M, Burgdorf W, Hertl M, Ruzicka T (eds.). Braun-Falco's Dermatologie, Venerologie und Allergologie. 6th edition. Berlin – Heidelberg: Springer, 2012. https://doi.org/10.1007/978-3-642-24163-5

Janarthanam J, Mahadevan S. Epidermoid cyst of submandibular region. J Oral Maxillofac Pathol. 2012; 16(3):435–7. https://doi.org/10.4103/0973-029X.102511 PMid:23248482 PMCid:PMC3519225

Kumar U, Lamba S. Intraosseous epidermal inclusion cyst of the great toe: masquerading as bone tumour. J Clin Diagn Res. 2017; 11(6):EJ01-EJ02. https://doi.org/10.7860/JCDR/2017/29249.10100

Yao PS, Lin ZY, Zheng SF, Lin YX, Yu LH, Jiang CZ, Kang DZ. Coexistence of intracranial epidermoid tumor and multiple cerebral aneurysms: A case report and literature review. Medicine (Baltimore). 2017; 96(5):e6012. https://doi.org/10.1097/MD.0000000000006012 PMid:28151901 PMCid:PMC5293464

Min HJ, Lee JM, Han JK, Kim YJ. Influence factor in thickness of cyst wall of epidermal cysts. J Craniofac Surg. 2017; 28(4):e369-72. https://doi.org/10.1097/SCS.0000000000003687 PMid:28328606

Ramakrishnaiah SB, Rajput SS, Gopinathan NS. Epidermoid cyst of the sole - a case report. J Clin Diagn Res. 2016; 10(11):PD06-PD07. https://doi.org/10.7860/JCDR/2016/23225.8787

Utumi ER, Araujo JP, Pedron IG, Yonezaki F, Machado GG, Rocha AC. Extensive epidermoid cyst of the submental region. Autops Case Rep. 2016; 6(2):51-4. https://doi.org/10.4322/acr.2016.031 PMid:27547744 PMCid:PMC4982785

Nishar CC, Ambulgekar VK, Gujrathi AB, Chavan PT. Unusually giant sublingual epidermoid cyst: a case report. Iran J Otorhinolaryngol. 2016; 28(87):291-6. PMid:27602342 PMCid:PMC4994990

Liau JL, Altamura D, Ratynska M, Verdolini R. Basal cell carcinoma arising from an epidermal cyst: when a cyst is not a cyst. Case Rep Dermatol. 2015; 7(1):75-8. https://doi.org/10.1159/000381393 PMid:26034477 PMCid:PMC4448066

Sze S, Richmond I, Bickers A, Saha A. Squamous cell carcinoma arising from a vulval epidermal cyst. J Obstet Gynaecol Res. 2016; 42(11):1623-6. https://doi.org/10.1111/jog.13091 PMid:27785896

Aljufairi E, Alhilli F. Merkel cell carcinoma arising in an epidermal cyst. Am J Dermatopathol. 2016; [Epub ahead of print].

Choi JE, Kwon IH, Seo SH, Kye YC, Ahn HH. Pathogenesis of plantar epidermal cyst: Three-dimensional reconstruction analysis. Ann Dermatol. 2016; 28(1):133-5. https://doi.org/10.5021/ad.2016.28.1.133 PMid:26848239 PMCid:PMC4737825

Egawa K, Egawa N, Honda Y. Human papillomavirus-associated plantar epidermoid cyst related to epidermoid metaplasia of the eccrine duct epithelium: a combined histological, immunohistochemical, DNA-DNA in situ hybridization and three-dimensional reconstruction analysis. Br J Dermatol. 2005; 152(5):961-7. https://doi.org/10.1111/j.1365-2133.2005.06562.x PMid:15888153

Koh KJ, Park HN, Kim KA. Gardner syndrome associated with multiple osteomas, intestinal polyposis, and epidermoid cysts. Imaging Sci Dent. 2016; 46(4):267-72. https://doi.org/10.5624/isd.2016.46.4.267 PMid:28035305 PMCid:PMC5192025

Ikehara S, Utani A. Multiple protrusive epidermal cysts on the scalp of a Lowe syndrome patient. J Dermatol. 2017; 44(1):105-7. https://doi.org/10.1111/1346-8138.13444 PMid:27178641

Reynolds N, Kenealy J. Use of a carbon dioxide laser in the treatment of multiple epidermoid cysts. Br J Plast Surg. 2002; 55(3):260-1. https://doi.org/10.1054/bjps.2002.3790 PMid:12041985

Feng CJ, Ma H. Treatment of epidermal cysts with erbium: YAG laser fenestration: an alternative to surgical intervention. Ann Plast Surg. 2015; 74(Suppl 2):S89-92. https://doi.org/10.1097/SAP.0000000000000463 PMid:25695444

Calderón-Castrat X, Santos-Durán JC, Román-Curto C, Fernández-López E. Carbon dioxide laser: A therapeutic approach for multiple vulvar epidermoid cysts. Dermatol Surg. 2016; 42(2):264-7. https://doi.org/10.1097/DSS.0000000000000614 PMid:26845541

Wollina U. Erbium-YAG laser therapy – analysis of more than 1,200 treatments. Glob Dermatol. 2016; 3(2):268-72. https://doi.org/10.15761/GOD.1000171

Morritt AN, Tiffin N, Brotherston TM. Squamous cell carcinoma arising in epidermoid cysts: report of four cases and review of the literature. J Plast Reconstr Aesthet Surg. 2012; 65(9):1267-9. https://doi.org/10.1016/j.bjps.2012.02.007 PMid:22364661

Published
2018-01-10
How to Cite
1.
Wollina U, Langner D, Tchernev G, França K, Lotti T. Epidermoid Cysts – A Wide Spectrum of Clinical Presentation and Successful Treatment by Surgery: A Retrospective 10-Year Analysis and Literature Review. Open Access Maced J Med Sci [Internet]. 2018Jan.10 [cited 2021Mar.4];6(1):28-0. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2018.027

Most read articles by the same author(s)

<< < 1 2 3 > >>