Influence of Interleukin-6 (174G/C) Gene Polymorphism on Obesity in Egyptian Children

  • Ola M. Ibrahim Child Health Department, Medical Division, National Research Centre
  • Azza A. Gabre Child Health Department, Medical Division, National Research Centre
  • Sara F. Sallam Child Health Department, Medical Division, National Research Centre
  • Inas R. El-Alameey Child Health Department, Medical Division, National Research Centre
  • Rania N. Sabry Child Health Department, Medical Division, National Research Centre
  • Essam M. Galal Child Health Department, Medical Division, National Research Centre
  • Sawsan M. Tawfik Child Health Department, Medical Division, National Research Centre
  • Waheba A. Zarouk Molecular Genetics & Enzymology Department , Human Genetics and Genome Research Division, National Research Centre
  • Rehab M. Mosaad Molecular Genetics & Enzymology Department , Human Genetics and Genome Research Division, National Research Centre
  • Abeer Ramadan Molecular Genetics & Enzymology Department , Human Genetics and Genome Research Division, National Research Centre
Keywords: Obesity, Interleukin-6(174 G/C), Children, polymorphism, Egypt

Abstract

BACKGROUND: Obesity is a multi-factorial chronic disorder. A considerable number of studies have been performed to figure out whether there is an association between obesity and polymorphisms of gene IL-6 (174G/C), but the results are equivocal.

AIM: This study aimed to find out whether the IL-6 (174G/C) gene was associated with the risk of developing obesity in Egyptian children.

SUBJECTS AND METHODS: The study included 149 children and adolescents with age ranged between 9.5 – 18 years. Eighty-five of them were obese which BMIZ-score is > 2, and sixty-four children with BMIZ-score ≤ 2 served as control group. Serum level of IL-6 and genetic analysis for IL-6 (174G/C) gene polymorphism were done.

RESULTS: Obese children had significantly higher serum levels of IL-6 as compared to those of control children (P = 0.003). A high percentage of IL-6 polymorphism GC was found in obese subjects (93.7%), while the control group had a higher percentage of IL-6 polymorphism GG (70.6 %).

CONCLUSION: Our study showed that carriers of the C allele for the IL-6 (174G/C) polymorphism have higher BMI. As the G174C polymorphism is likely to affect IL-6 expression and its physiological regulation; consequently this polymorphism may affect adiposity.

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Published
2017-10-17
How to Cite
1.
Ibrahim OM, Gabre AA, Sallam SF, El-Alameey IR, Sabry RN, Galal EM, Tawfik SM, Zarouk WA, Mosaad RM, Ramadan A. Influence of Interleukin-6 (174G/C) Gene Polymorphism on Obesity in Egyptian Children. Open Access Maced J Med Sci [Internet]. 2017Oct.17 [cited 2020Oct.26];5(7):831-5. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2017.175
Section
A - Basic Science