Fasting Ghrelin Levels Are Decreased in Obese Subjects and Are Significantly Related With Insulin Resistance and Body Mass Index

  • Dimitrios Papandreou Department of Health Sciences, CNHS, Zayed University, Abu Dhabi
  • Christos Karavolias The Doctors Medical Center, Abu Dhabi
  • Fotini Arvaniti Medical Unit, Hellenic House of Parliament, Athens
  • Eleana Kafeza College of Technological Innovation, Zayed University, Abu Dhabi
  • Fatima Sidawi Department of Health Sciences, CNHS, Zayed University, Abu Dhabi
Keywords: Ghrelin, obesity, Insulin resistance, glucose, Body mass Index

Abstract

BACKGROUND: Ghrelin is a 28-amino acid peptide that predominantly produced by the stomach. Strong evidence indicates the effects of ghrelin in the regulation of metabolic functions and its potential role in the aetiology of obesity.

AIM: The aim of this study was to investigate the relationship of ghrelin levels with obesity, insulin resistance and glucose in normal and obese subjects.

METHODS: Thirteen normal (n = 13) and seven (n = 7) obese weight subjects aged 20-22 participated in the study. Fasting plasma ghrelin, insulin and glucose levels were measured after overnight fasting. HOMA-IR was calculated to evaluate insulin resistance.

RESULTS: Ghrelin and insulin levels were found to be statistically significantly lower and higher in obese subjects (P < 0.001), respectively. Glucose levels were clinically higher in obese subjects but not statistically significant. Fasting plasma ghrelin was negatively correlated with BMI (r = -0.77, P < 0.001), fasting insulin levels (r = -0.55, P < 0.001) and HOMA-IR (r = -0.66, P < 0.001). There was no correlation between ghrelin and glucose. In multiple regression analysis, insulin levels (Beta: -2.66, 95% CI: -2.49, -2.78, P < 0.001) HOMA-IR (Beta: -2.41, 95% CI: -2.33, -2.55, P < 0.001) and BMI (Beta: -1.77, 95% CI: -1.66, -1.89, P < 0.001) were significant independent determinants of fasting ghrelin.

CONCLUSION: Obese subjects have low fasting ghrelin levels that they are significantly related to insulin resistance and body mass index. More prospective studies are needed to establish the role of ghrelin in the pathogenesis of human obesity.

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Author Biography

Dimitrios Papandreou, Department of Health Sciences, CNHS, Zayed University, Abu Dhabi
Place of birth: Naoussa Imathias, Greece Date of birth: 21 October 1969 Mobile: +971 527677647 +30 697 5583244 e-mail: papandreoudimitrios@yahoo.gr Education: 2008 Ph.D. in Medicine (Clinical Nutrition) from Aristotle University of Thessaloniki, School of Medicine, Greece 1998 Master of Education in Community Nutrition. Columbia University, New York, NY, USA. 1998 Master of Science in Exercise Physiology and Nutrition Columbia University, New York, NY, USA. 1996 Bachelor of Science in Nutrition and Food Science (Hons) focused in Clinical Nutrition, Hunter College of City University of New York, USA. Licenses/ Certifications: 2015-2017 Clinical Dietitian HAAD, ID: AGT86182 2014 Mobile Enhanced Learning Leadership Certificate Zayed University, Abudhabi, UAE 1998- Today Registered Dietitian (RD), American Dietetic Association. ID: 846612 Work Experience Academic 2013 Aug-Current Associate Professor of Nutrition Zayed University, CSSH, Department of Natural Science & Public Health AbuDhabi, UAE. Courses taught: Principles of Nutrition I, Principles of Nutrition II, Diet Planning and Assessment, Medical Nutrition Therapy I, Research Seminar 2008 Sept-2013 July Assistant Professor of Nutrition University of Nicosia, Department of Life and Health Sciences, Nicosia, Cyprus. Courses taught: Introduction to Human Nutrition and Health, Principles of Nutrition Biochemistry I, Principles of Nutrition Biochemistry II, Medical Nutrition Therapy I, Medical Nutrition Therapy II, Nutrition Through the Life Cycle, Sport and Exercise Nutrition, Food, Culture and Nutrition, Communication Skills & Nutritional Counseling. 2002-2003 Teaching Assistant of Nutrition Medical School of Dentistry, Aristotle University of Thessaloniki, Greece. Courses taught: Introduction to Nutrition 1999-2003 Lecturer in Nutrition, Technological Institute of Thessaloniki, Department of Nutrition, Thessaloniki, Greece. Courses taught: Introduction to Nutrition, Medical Nutrition Therapy I & II & III, Body composition in exercise and athletes Non- Academic 2004-2008 Research Assistant- Pediatric Endocrinology Obesity Clinic, (educate nutrition in children with obesity and diabetes type I and II) Ahepa General Hospital, School of Medicine, Aristotle University of Thessaloniki, Greece. 1998-2008 Private Practice- Dietitian Office, Thessaloniki, Greece. 2000-2002 Clinical Dietitian of Diabetes Medical Center << ASKLIPIOS>>Greece. 1999-2003 Scientific Advisor of “Science Technologies Company†Athens, Greece 1999-2000 Sports Dietitian in First Basketball team of Aris Thessalonikis, Greece 1998-2001 Clinical Dietitian of Diabetes Medical Center “EYRODIAGNOSIâ€, Greece. 1998-2008 Private Practice-Dietitian Office, Thessaloniki, Greece. 1997-1998 Assistant Dietitian of Basketball team New York Nicks Research Experience June 2015-2017 Principal Investigator (RIF) Grant- Zayed University Title: Effects of orange and various orange juices to plasma glucose and insulin responses. An Acute postprandial study . Oct 2013-15 Principal Investigator (RIF) Grant-Zayed University Title: Neck Circumference-­†A novel simple non-­â€invasive instrument to measure obesity. Relation with other cardiovascular indices. Oct 2013-15 Research Collaborator (RIF) - Zayed University Title: Genetic Variants and Association of Vitamin D deficiency with Type 2 Diabetes Mellitus Among UAE Nationals. Oct 2013-14 Principal Investigator (Startup Grant)-Zayed University Title: Development , reproducibility and validity of a Food Frequency Questionnaire for vitamin D and Calcium Intake in female college students. Feb 2012 Research Collaborator-University of Nicosia Title: “Multidisciplinary approach of obesity prevention in early childhood: use of behavioral models to understand the factors that affect nutrition and physical activity with the aim of shaping health policies to promote a balanced lifestyle: ToyBox from 1/3/2010-31/8/2013. Jan 2008 Research Collaborator-University of Nicosia Title: "Protection of health of the child population of the border zone for the prevention of cardiovascular disease with application instructions and use of new techniques / technologies". Nov 2007 Research Collaborator-University of Nicosia Title: "Protection of health of the child population of the border zone for the prevention of cardiovascular disease with application instructions and use of new techniques / technologiesâ€. Jan 2006 Principal Investigator- Aristotle University of Thessaloniki, School of Medicine Title: Pediatric obesity and related CVD factors. Apr 2005 Principal Investigator- Aristotle University of Thessaloniki, School of Medicine Title: Non alcoholic Fatty liver disease in children and its relation to diet. Administrative Experience Department of Natural Science and Public Health, Zayed University, UAE. Febr 2015-today Chair of CSSH Research Committee Aug 2013-today Active participation on departmental and college meetings Faculty Promotion Committee of the College Member of the search committed for the position of Endowed Chair in Public Health Advisor of undergraduate students Member of Kitchen committee Chief Editor of International Journal of Nutrition and Exercise 2008-2013 Department of Life and Health Sciences, University of Nicosia , Cyprus. Associate chair of Nutrition Department Active participation in the development of the undergraduate nutrition program. Active participation in the development of the master’s nutrition programs Active participation on Departmental and University meetings Advisor of undergraduate students in clinical settings for their final project. Advisory committee on Cyprus Dietetic Association 2007-2009 Greek Dietetic Association Representative of the Greek Dietetic Association on EFAD (European Federation of the Association of Dietitians) Awards: 2016 Faculty Scholarship List- Zayed University 2015 Faculty Scholarship List-Zayed University 2011 Excellence Award-Emerald Literati (Highly Commended Paper). “Effects of low vitamin D status on rickets and type 1 diabetes in children†1997-1998 Scholarship Award, Columbia University, New York, NY, USA. 1998 Award of Recognition of Excellence in Scholarship in Nutrition and Food Science, Hunter College, NY, USA 1996 Rose Mary Visally Mirenda Award Hunter College, NY, USA. 1996 Certificate of Achievement Hunter College, NY, USA 1994 Award of Medical Applications of Research and Education, National Institute of Health, USA Doctorate dissertation 2004-2008 Topic: Serum homocysteine, folic acid and vitamin B12 levels in healthy children aged 6-15 years old and relation to diet. Master thesis 1997-1998 Topic: Effects of progressive resistance exercise in body cell mass and muscle strength in women with HIV. Attending seminars & Conferences: 1. Dubai Nutrition Conference (Invited Speaker) 19-21 November 2015, Dubai, UAE 2. The 5th World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension. 5-7 Nov 2015, Istanbul, turkey 3. 8th International Conference of the Cyprus Dietetic Association 27-30 Noe 2014, Nicosia Cyprus (INVITED SPEAKER) 4. Mobile Enhanced Learning Leadership Certificate. 26 Oct, 2 Nov, 16 Nov, Zayed University AbuDhabi UAE 5. Knowledge Workshop: Successful Journal Publishing-Developing A journal 10-20 Oct 2014, Dubai, UAE 4. 7th International Confeence of the Cyprus Dietetic Association 29-2 Noe 2012, Nicosia, Cyprus (INVITED SPEAKER) 5. 5th International conference of the Cyprus Dietetic Association 28-30 November 2008, Nicosia, Cyprus. (Invited Speaker) 6. 3rd Balkan Congress on Obesity 17-19 October 2008, Thessaloniki Greece 7. 8th Macedonian Congress on nutrition and Dietetics 16-17 October 2008, Thessaloniki Greece. 8. 2nd Conference of the DIETS Thematic Network 25-26 September 2008, Frankfurt/Main, Germany 9. 19th General Meeting of the European Federation of the Associations of Dietitians 24-27 September 2008, Frankfurt/Main, Germany 10. 9th Dietetic Greek Congress of Nutrition 7-9 December 2007, Athens, Greece. 11. 18th General Meeting of the European federation of the Association of Dieticians 27-29 Sept 2007, Giardini Naxos, Italy. 12. 29th Espen Congress, The European Society For Clinical Nutrition And Metabolism 8-11 October 2007, Praque,Czech Republic 13. 28th Espen Congress, The European Society For Clinical Nutrition And Metabolism 19-22 October 2006 – Instabul, Turkey 14. The 39th Annual Meeting of Espghan, European Society for Paediatric Gastroenterology, Hepatology and Nutrition 7-10 June, Dresden, Germany. 15. 8th Dietetic Greek Congress of Nutrition 9-11 December 2005 – Athens –Hellenic Dietetic Association, Greece 16. 16th Scientific Meeting 2nd Paediatric Department 15 October 2005 –General Hospital AHEPA – Thessaloniki, Greece 17. 27th Espen Congress, The European Society For Clinical Nutrition And Metabolism 27-30 August 2005 – Brussels - Belgium 18. Advanced Sports Nutrition – The Science with Practical Applications 12-13 June 2005, Limassol – Cyprus 19. 3rd Scientific Conference of Medical School (Aristotle Unicersity of Thessaloniki) 10-13 April 2005 – Hotel Makedonia Palace - Thessaloniki, Greece 20. Exercise, Nutrition and Maternity 1 Dec 2004 –PEPGAS. – Thessaloniki, Greece 21. 6th Macedonian Conference of Nutrition 19-21 Îovember 2004 Thessaloniki Greece 22. 15th Scientific Meeting of 2nd Paediatric Department 16 Octomber 2004 – General Hospital AHEPA – Thessaloniki, Greece 23. 7th Dietetic Greek Congress of Nutrition 14-16 November 2003 – DIVANI-CARAVEL – Athens, Greece 24. 17th Annual Conference of Northern Greece Diabetes Society 13 November 2003 –MAKEDONIA PALACE HOTEL - Thessaloniki, Greece 25. 10th International Conference Exercise and Sports 17-19 May 2002, Komotini, Greece 26. 2nd Congress of Cyprus Association 26-28 April 2002, Nicosia,Cyprus 27. 2nd Scientific Meeting – Greek Obesity Society 19-20 April 2002 Intercontinental, Athens, Greece 28. 4th Greek Medical Conference of Nutrition and Dietetics 15-17 February 2001 , Hilton, Athens, Greece 29. 6th Greek Conference of Nutrition and Dietetics 25 November 2000, Hilton – Athens, Greece 30. 10th Greek Symposium of Athletics Science Society 12 December 1999,Congress Center (I. Velidis) – Thessaloniki, Greece 31. Educational seminars of exercise and diet “Diet and Sports†11 December 1999, Dept of Phys Educ – Aristotle University of Thessaloniki, Greece 32. 4th Macedonian Conference on Nutrition and Dietetics 28-29 May 1999, Congress Center (I. Velidis) – Thessaloniki, Greece 33. 10th Greek Conference of ΑΙDS 19-21 November 1998, Athens, Greece Book Publications Monographs “Diet in Pregnancy and Lactationâ€.(Greek) Published by Christodoulidi. Οctober 2003. ΙSBN: 960-8183-38-3 Chapters 1. 8 Chapters in the book “Principles of Clinical Nutrition & Nutritional therapeutics†(Greek) Chourdakis M. K., Kouvelas D. A. December of 2007, ISBN:978-960-98037-1-7 1. Nutrition and bone health – Tsagari A, Papandreou D, Chourdakis M. 2. Nutrition during pregnancy – Papandreou D, Sardelli Ch, Chourdakis M. 3. Therapy approach of obesity - Risvas G, Papalazarou A, Chourdakis M, Papandreou D, Kouvelas D. 4. Nutrient support for diabetes – Vassilakou D, Papandreou D, Chourdakis M. 5. Nutrition and cardiovascular diseases –Giannoulaki N, Chourdakis M, Papandreou D. 6. Nutrition and respiratory diseases – Arvaniti F, Papandreou D, Chourdakis M. 7. Nutrition and neurological and psychiatric –Ksenos K, Malachas K, Papandreou D, Papazisis G, Chourdakis M. 8. Nutrition and cancer – Kanellou A, Drakopoulou Ch, Papandreou D, Chourdakis M. 2. One chapter (1) in the book «Pediatrics and Adolescent Primary Care from Dr. Chrysanthopoulos. Topic: “Nutrition in infants, children and adolescent ages†(Published 2012) Manuals 1. Nutrition Glossary book- Zayed University- Editing and Translation of English to Arabic Published 2015 (Author) (English) 2.Nutrition Glossary book- University of Nicosia-Editing and Translation of English to Greek-Published 2011 (Co-Author). (English) Analysis of Published Papers Number Impact Factor (IF) Α. Full papers in foreign Journals 56 59.1 B. Abstracts in foreign congresses and 27 85.5 Journals D. Full papers in Greek Journals 16 E. Abstracts in Greek congresses and Journals 12 Total 112 145 CITATION INDEX 555 h-Index 13 i-10 index 17 Papers being as a 1st author 67 Papers being as a 2nd author 21 Reviewer in International Journals Public Health Nutrition, International Journal for Vitamin and Nutrition Research, European Journal of Clinical Nutrition, International Journal of Medicine and Medical Science, Obesity Reviews Journal of Paediatric Biochemistry Editorial Board in International Journals Chief Editor- Arab Journal of Nutrition and Exercise Lead Guest Editor- Disease Markers Feb 2015-Sept 2015 Member of Editorial Board- Journal of Public Health and Epidemiology Member of Editorial Board- World J of Hepatology Member of Editorial Board- Journal of Diabetes and Endocrinology Member of Editorial Board-World J of Clinical Pediatrics Member of Editorial Board-Nutrition and Food Science ORIGINAL PUBLICATIONS Α. Full published and in press papers on peer-reviewed international journals 1. Agin D, Kotler DP, Papandreou D, Liss M, Wang J, Thomton J, Gallagher D, Pierson RN Jr. Effects of whey protein and resistance exercise on body composition and muscle strength in women with HIV infection. Ann N Y Acad Sci 2000; 607-609. IMPACT FACTOR: 4.039 CITATION INDEX: 13 (PUBMED) 2. Papandreou D, Mavromichalis I, Makedou A, Rousso I, Arvanitidou M. Total serum homocysteine, folate and vitamin B12 in a Greek school age population. Clinical Nutrition 2006; 25: 797-802. IMPACT FACTOR: 4.476 CITATION INDEX: 20 (PUBMED) 3. Papandreou D, Mavromichalis I, Makedou A, Rousso I, Arvanitidou M. Reference range of total serum homocysteine levels and dietary indexes in Greek healthy school children aged 6-15 y. British Journal of Nutrition 2006; 99 (4): 719-724. IMPACT FACTOR: 3.453 CITATION INDEX:17 (PUBMED) 4. Papandreou D, Pavlou E, Kalimeri E, Mavromichalis I. Ketogenic diet in children with epilepsy. British Journal of Nutrition 2006; 95: 5-13. IMPACT FACTOR: 3.453 CITATION INDEX: 27 (PUBMED) 5. Papandreou D, Hassapidou MN, Hourdakis M, Papakonstantinou K, Tsitskaris G, Garefis A. Dietary intakes of elite athletes. Aristotle University Medical Journal 2006; 33 (1): 119-126. CITATION INDEX: 2 (INDEX COPERNICUS INTERNATIONAL) 6. Papandreou D, Makedou A, Bouzouki V, Rousso I. The effects of diet and strength training in serum lipid concentration among obese Greek children. Aristotle University Medical Journal 2006; 33 (2): 53-58. (INDEX COPERNICUS INTERNATIONAL) 7. Kouvelas D, Hourdakis M, Papandreou D, Vassilakou D. A critical approach to fad diets and obesity drugs – the adoption of a healthy diet. Aristotle University Medical Journal 2006; 33 (1): 157-163. (INDEX COPERNICUS INDERNATIONAL) 8. Hourdakis M, Papandreou D, Giala M. The role of B-vitamins and sulfur-nutrient keys such as carnitine, epinephrine and melatonin in homocysteine metabolism in relation to health and disease. Aristotle University Medical Journal 2006; 33 (1): 149-155. (INDEX COPERNICUS INTERNATIONAL) 9. Papandreou D, Stamou M, Malindretos P, Rousso I, Mavromichalis I. Prevalence of hypertension and association of dietary mineral intake with blood pressure in healthy school children from northern Greece aged 7-15 years. Annals of Nutrition and Metabolism 2007; 51: 471-476. IMPACT FACTOR: 2.618 CITATION INDEX: 18 (PUBMED) 10. Papandreou D, Bouzouki V, Eustathiadis P, Hassapidou M. Dietary assessment, anthropometric measurements and nutritional status of Greek professional athletes. Nutrition and Food Science 2007; 37 (5): 338-344. CITATION INDEX: 1 (SCOPUS) 11. Papandreou D, Rousso I, Mavromichalis I. Non-alcoholic fatty liver disease in children. Current Nutrition & Food Science 2007; 3: 141-144. (SCOPUS) 12. Papandreou D, Rousso I, Makedou A, Arvanitidou M, Mavromichalis I. Association of blood pressure, obesity and serum homocysteine levels in healthy children. Acta Paediatrica 2007; 96: 1819-1823. IMPACT FACTOR: 1.674 CITATION INDEX: 22 (PUBMED) 13. Papandreou D, Stamou M, Papantoniou E. Hypertension in children. Aristotle University Medical Journal 2007; 34 (1): 25-30. (INDEX COPERNICUS INTERNATIONAL) 14. Emporiadou M, Papandreou D. The role of antioxidants, fatty acids and maternal diet to children with asthma and allergy. Aristotle University Medical Journal 2007; 34 (1): 17-23. (INDEX COPERNICUS INTERNATIONAL) 15. Rousso I, Kourti M, Papandreou D, Tragiannidis A, Athanassiadou F. Central precocious puberty due to hypothalamic hamartoma in a 7-month-old infant girl. Eur J Pediatr 2007; 167 (5): 583-585. IMPACT FACTOR: 1.890 CITATION INDEX: 10 (PUBMED) 16. Papandreou D, Rousso I, Mavromichalis I. Update on non-alcoholic fatty liver disease in children. Clinical Nutrition 2007; 26: 409-415. IMPACT FACTOR: 4.476 CITATION INDEX: 106 (PUBMED) INVITED 17. Papandreou D, Rousso I, Malindretos P, Madedou A, Moudiou T, Pidonia I, Pantoleon A, Economou I, Mavromichalis I. Are saturated fatty acids and insulin resistance associated with fatty liver in obese children? Clin Nutr. 2008; 27 (2): 233-240. IMPACT FACTOR: 4.476 CITATION INDEX: 17 (PUBMED) 18. Papandreou D, Malindretos P, Rousso I. Investigation of dietary intake and obesity status in a pediatric population from northern Greece. Nutrition and Food Science 2008; 38 (6): 526-533. CITATION INDEX: 4 (SCOPUS) 19. Papandreou D, Athanassiadou F. Are maternal diet, birth weight, breastfeeding and antioxidants playing a role in pediatric leukemia? A review. Nutrition and Food Science 2008; 38 (1): 32-40. (SCOPUS) 20. Papandreou D, Rousso I, Economou I, Makedou A, Moudiou T, Malindretos P, Pidonia I, Pantoleon A, Mavromichalis I. Is there any association between HDL, insulin resistance and non-alcoholic fatty liver disease in obese children? International Journal of Food Sciences and Nutrition 2009; 60 (4): 312-318. IMPACT FACTOR: 1.260 CITATION INDEX: 5 (PUBMED) 21. Papandreou D, Malindretos P, Arvanitidou M, Makedou A, Rousso I. Homocysteine lowering with folic acid supplements in children: effects on blood pressure. International Journal of Food Sciences and Nutrition 2010; 61 (1): 11-17. IMPACT FACTOR: 1.260 CITATION INDEX: 11 (PUBMED) 22. Papandreou D, Malindretos P, Rousso I. Risk factors for childhood obesity in a Greek pediatric population. Public Health Nutrition 2010; Jan 15: 1-5. IMPACT FACTOR: 2.679 CITATION INDEX:9 (PUBMED) 23. Papandreou D, Malindretos P, Arvanitidou M, Makedou A, Rousso I. Oral supplementation of oral folic acid for 2 months reduces total serum homocysteine levels in hypehomocysteinemic Greek children. Hippokratia 2010; 14 (2): 105-108. IMPACT FACTOR: 0.589 CITATION INDEX: 2 (PUBMED CENTRAL) 24. Papandreou D, Malindretos P, Karabouta Z, Rousso I. Possible health implications and low vitamin D status during childhood and adolescence – an updated mini review. International Journal of Endocrinology. 2010, doi: 10.1155/2010/472173. IMPACT FACTOR: 1.948 CITATION INDEX: 25 (PUBMED) INVITED 25. Papandreou D, Malindretos P, Rousso I. First body fat percentiles for 607 children from Thessaloniki-Northern Greece. Hippokratia 2010;14 (3):208-211 IMPACT FACTOR: 0.589 CITATION INDEX:3 (PUBMED CENTRAL) 26. Papandreou D, Rousso I, Malindretos P, Makedou A, Arvanitidou M. Effects of oral folate supplementation on serum total homocysteine and cholesterol levels in hyperhomocysteinemic children. Nutrition in Clinical Practice 2010, 25:390-393 IMPACT FACTOR: 2.401 CITATION INDEX: 5 (PUBMED) 27. Hourdakis M, Papandreou D, Malindretos P, Vassilakou D, Papastergiou N, Tantsidis D, Kouvelas D. Effect of Greek orthodox Easter holidays on body weight. Nutrition and Food Science 2010; 40 (1): 49-54 (SCOPUS) 28. Papandreou D, Karabouta Z, Rousso I. Effects of low vitamin D status in rickets and type 1 diabetes in children. Nutrition and Food Science 2010, 40(5):447-455 (SCOPUS) 29. Papandreou D, Malindretos P, Rousso I. First reference curves of waist circumference and waist-to-height ratio of 607 children from Thessaloniki-Northern Greece. Nutrition and Food Science 2010, 40(4):371-377 (SCOPUS) 30. Karambola M, Papandreou D, Makedou K. The role of Mediterranean diet in health and disease: an updated mini review. Nutrition and Food Science 2011:41(1);63-72 CITATION INDEX: 1 (SCOPUS) 31. Papandreou D. Prevalence of Hypertension is about 1-2% in African American girls and 0.5% in Caucasian girls aged 9 or 10 years, and prevalence is increased with obesity. Evid Based Med 2011;16(2):63-64 (PUBMED) INVITED 32. Andreou E., Philippou Ch., Papandreou D. Effects of an intervention and maintenance weight loss diet with and without exercise on anthropometric indices in overweight and obese healthy female women. Ann Nutr Metab 2011; 59:187-192 IMPACT FACTOR: 2.618 CITATION INDEX: 4 (PUBMED) 33. Makedou K. Karampola M. Papandreou D. et al. Prevalence of childhood obesity in schools of Northern Greece. Aristotle University Medical Journal.2011:38 (1)17-19 (INDEX COPERNICUS INTERNATIONAL) 34. Philippou Ch., Andreou E., Menelaou N.,Hajigeorgiou Ph., Papandreou D. Effects of Diet and Exercise in 337 overweight/obese adults. Hippokratia Journal 2012;16(1):449-453 IMPACT FACTOR: 0.589 CITATION INDEX:1 (PUBMED CENTRAL) 35. Andreou E. Philippou C. Papandreou D. Dietary intakes and anthropometric indices of 337 adults from Cyprus. Nutrition and Food Science 2012;42(2):80-86 (SCOPUS) 36. Toliopoulos I. Simos Y. Verginadis I. Papandreou D. et al. Anticancer activities of kefir against LMS and K562 cell lines by flow cytometry analysis. Nutrition and Food Science 2012;42(4):261-270 (SCOPUS) 37. Andreou E, Hajigeorgiou PG, Kyriakou K, Avraam Th, Chappa G, Kallis P, Lazarou Ch, Philippou Ch Christoforou C, Kokkinofta R, Dioghenous C Savva SC, Kafatos A, Zampelas A, Papandreou D. Risk factors of obesity in a 1001 Cypriot adults: An epidemiological study. Hipokkratia 2012;16(3):256-260 IMPACT FACTOR: 0.589 CITATION INDEX: 0 (PUBMED CENTRAL) 38. Papandreou D. Karabouta Z. Rousso I. Are dietary cholesterol intake and serum cholesterol levels related to non-alcoholic fatty liver disease in obese children? Cholesterol 2012. doi:10.1155/2012/572820. IMPACT FACTOR: 0 CITATION INDEX: 8 (PUBMED) INVITED 39. Papandreou D, Karabouta Z, Pantoleon A, Rousso I. Investigation of anthropometric, biochemical and dietary parameters of obese children with and without non-alcoholic fatty liver disease Appetite 2012;(18)59:939-944 IMPACT FACTOR: 2.691 CITATION INDEX: 3 (PUBMED) 40. Platritis P. Andreou E. Papandreou D. Caffeine effect on exercise performance and disease issues: an updated mini review. Nutr and food Science 2013;43(3):243-53 9 (SCOPUS) 41. Papandreou D. Andreou E. Heraklidis A. Rousso I. Is Beverage intake related to overweight and obesity in school children? Hippokratia, 2013;17(1):42-46 IMPACT FACTOR: 0.589 (PUBMED CENTRAL) PAPERS AT ZAYED UNIVERSITY-AFTER PROMOTION TO ASSOCIATE PROFESSOR 42. Moschonis G, Papandreou D, Mavrogianni CH, Giannopoulou A, Damianidi L, Malindretos P, Lionis C, Chrousos G and Manios Y. Iron depletion in pubertal girls is associated with menstruation but not with dietary intake indices. The Healthy Growth study. Bio Med Research International. (Journal of Biomedicine and Biotechnology) DOI:10.1155/2013/423263. IMPACT FACTOR: 1.579 (PUBMED, SCOPUS) 43. Lily E. Papandreou D. The role and effects of carnosine and β-alanine on exercise: An updated mini review. Nutr and Food Science. 2014; 44(2):127-133 (SCOPUS) 44. Papandreou D. Phily A. An update mini review on Grapefruit: Interactions with drugs, obesity and cardiovascular risk factors. Food and Nutrition Sciences. 2014; 5: 376-381. IMPACT FACTOR: 0.85 (ISI WEB OF KNOWLEDGE) 45. Papandreou D. Rousso I. Mavromichalis I. Relation of cardiovascular risk factors with obesity in children aged 8-15 years old. Experimental & Clinical Cardiology 2014; 20 (1): 779-789 (SCOPUS) 46. Andreou E, Papandreou D, Hajigeorgiou P, et al. Non-HDL and Triglycerides are independently associated with anthropometrical indices in a Cypriot population of healthy adults. Experimental & Clinical Cardiology, 2014; 20 (6):3682-3692.(SCOPUS) 47. Papandreou D. Karabouta Z. Pantoleon A. Sidiropoulou A. Rousso I. Cardiometabolic risk factors related to non-alcoholic fatty liver disease in obese children. Experimental & Clinical Cardiology, 2014; 20 (8): 2194-2205. IMPACT FACTOR: (SCOPUS) 48.Papandreou D, Hanadi Almessabi, Shamma Al Saad, Aaesha AlShehhi, Alya AlMansoori. A review of the role of fiber, phytochemicals, and omega 3 fatty acids in cardiovascular disease. Experimental & Clinical Cardiology, 2014;20 (8):2181-2193 (SCOPUS) 49. Papandreou D, Nikolaos Rachaniotis, Maryam Lari, Wafa Al Mussabi. Validation of a Food frequency Questionnaire for Vitamin D and Calcium intake in healthy female college students. Food and Nutrition Sciences. 2014, 21 (5), 2048-2052. http://dx.doi.org/10.4236/fns.2014.521216 , IF 0.85 (ISI WEB OF KNOWLEDGE) 50. Papandreou D, Zujaja-Tul-Noor, Maitha Rashed. The role of Soluble, Insoluble fibers and their Bioactive Compounds in Cancer: A Mini Review. Food and Nutrition Sciences, 2015, 6, 1-11. http://dx.doi.org/10.4236/fns.2015.61001. IF 0.85 (ISI WEB OF KNOWLEGE) 51. Papandreou D. Andreou E. Role of diet on non-alcoholic fatty liver disease. An updated narrative review. World J Hepatology, 2015;7(3):575-582 (PUBMED, SCOPUS) INVITED 52. Papandreou D. Tul Noor Z. The role of Vitamin D in Diabetes and Cardiovascular disease. An update review of the literature. Disease Markers 2015. http://dx.doi.org/10.1155/2015/580474 (PUBMED, SCOPUS), IF 1.562) 53. Papandreou D, Tul Noor Z, Rashed M, Al Jaberi H. Association of Neck Circumference with Obesity in Female College Students. Macedonian Journal of Medical Sciences, 2015; 3(4):578-581. http://dx.doi.org/10.3889/oamjms.2015.118 (SCOPUS, PubMed) 54. Papandreou D, Causapin M, Tul-Noor Z, Malindretos P. Relation of Neck Circumference with Total Body Fat and BMI. Current Nutrition and Food Science . 2016; (2): 121-124 (SCOPUS) 55. Papandreou D, Makedou K, Zormpa A, Karampola M, Ioannou A, Hitoglou-Makedou A. Are Dietary Intakes related to Obesity in Children? Macedonian Journal of Medical Sciences. Published online first March 22, 2016. http://dx.doi.org/10.3889/oamjms.2016.045 (SCOPUS, PubMed) 56. Karabouta Z, Papandreou D, Makedou A, Rousso I, Athanassiadou F. Relation of cardiometabolic risk factors in obese and non-obese children with and without family history of cardiovascular disease. Journal of Clinical Medicine Research. 2016; 8 (6): 431-436 (PUBMED) 57. Papandreou D, Hajigeorgiou P Kyriakou K, Avraam T, Chappa G, Kallis P, Causapin M, Lazarou Ch, Philippou Ch, Christoforou C, Kokkinofta R, Dioghenous C, Savva S, Kafatos A, Zampelas A, Andreou E. First Nationwide Study of the Prevalence of Type 2 Diabetes and its correlates among Cypriot Healthy Adults. Public Health Nutrition (Under Review). B. Published Abstracts in peer reviewed international journals & Conference books 1. Vourloumi H, Samara G, Papandreou D, Kouidi E. Evaluation of “cardiac†symptoms in middle aged exercise participants. First Euro-Asian sports medicine congress and films team physicians development course. 2. Papandreou D. Dietetics approach from old to new concepts. 2nd Cyprus Dietetic Association Conference Nicosia 2002. 3. Papandreou D, Mavromichalis I, Makedou A, Rousso I, Arvanitidou M. Total serum homocysteine levels in Greek children. Clinical Nutrition 2005; 24 (4): 4 LB006. Impact Factor: 4.476 4. Makedou A, Makedou K, Papandreou D, Kourti M, Mavromichalis I. Dietary intervention in children with familial hypercholesterenemia. Clinical Nutrition 2005; 24 (4); 4 LB012 Impact Factor: 4.476 5. Nanas K, Tzouvelakis G, Papandreou D, Katsiki N, Mavromichalis I. Out of school activities of normal, overweight an obese children aged 12-15 y in Northern Greece. Clinical Nutrition 2005; 24 (4): 6 LB005. Impact Factor: 4.476 6. Mavromichalis I, Papandreou D, Makedou A, Rousso I, Arvanitidou M. Total serum homocysteine levels and its association with dietary indexes in Greek healthy school age children aged 6-15 y. Journal of Pediatric Gastroenterology and Nutrition 2006; 42 PN2-10. Impact Factor: 2.625 7. Papandreou D, Mavromichalis I, Makedou A, Rousso I, Arvanitidou M. Blood pressure and total serum homocysteine levels in normal, overweight and obese children. Journal of Pediatric Gastroenterology and Nutrition 2006; 42 PND-04. Impact Factor: 2.625 8. Mastori C, Papandreou D, Mandalianou D, Eystathiadis P. The use of waist circumference for measuring obesity in children and adolescents in North Greece. Journal of Pediatric Gastroenterology and Nutrition 2006; 42 PND-02. Impact Factor: 2.625 9. Mandalianou C, Mastori C, Papandreou D, Eystathiadis P. Body fat levels as indicator of childhood obesity. Journal of Pediatric Gastroenterology and Nutrition 2006; 42 PND-03. Impact Factor: 2.625 10. Palatou P, Papandreou D, Bouzouki V, Samara D, Eystathiadis P. Is overweight and obesity related to activities in Greek children aged 7-9 y.? e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism 2006; 1 p 238-239. 11. Papandreou D, Rousso I, Bouzouki V, Arvanitidou M, Makedou A, Pidonia I, Pantoleon A, Economou I, Mavromichalis I. Is non-alcoholic fatty liver disease in obese children associated with lipid profile and anthropometric measurements? e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism 2006; 1 p 238-239. 12. Samara D, Papandreou D, Bouzouki V, Palatou P, Eystathiadis P. Correlation of sleep-disordered breathing and anthropometric indices in obese children. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism 2006; 1: 239. 13. Bouzouki V, Papandreou D, Palatou P, Samara D, Eystathiadis P. Prevalence of obesity and hypertension in Greek children. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism 2006; 1: 221 LB07. 14. Papandreou D, Rousso I, Moudiou T, Makedou A, Pidonia I, Pantoleon A, Economou I, Mavromichalis I. Is non-alcoholic fatty liver disease in obese children associated with insulin resistance and waist circumference? J Pediatr Gastroenterol Nutr. 2007; 44 (6): 77 PN1-21. Impact Factor: 2.625 15.Papandreou D, Rousso I, Makedou A, Moudiou T, Malindretos P. Are oral glucose insulin sensitivity index and other anthropometrical indexes associated with non-alcoholic fatty liver disease in children? Obesity Reviews 8 (3) 2007; 8 O005. Impact Factor : 7.995 16. Papandreou D, Rousso I, Moudiou T, Makedou A, Pidonia I, Pantoleon N, Economou I, Makedou K, Mavromichalis I. Are there any dietary intake differences in obese Greek children with and without nonalcoholic fatty liver disease? Journal of Pediatric Gastroenterology and Nutrition 2007; 44 e332. Impact Factor: 2.625 17. Papandreou D, Malindretos P, Stamou M, Rousso I. Systolic blood pressure is related to age, BMI and dietary potassium and calcium but not to dietary sodium intake in children aged 7-15 from Northern Greece. Obesity Reviews 8 (3) 2007; 9 O009 Impact Factor: 7.995 18. Papandreou D, Arvanitidou M, Malindretos P, Rousso I. Prevalence of Obesity and Relation to Dietary Status in Healthy Schoolchildren from Northern Greece. Obesity Reviews 8 (3) 2007; 28 P036. Impact Factor : 7.995 19. Makedou K, Moschous E, Papandreou D, Kourtis A, Hitoglou A. Childhood obesity in schools of the region of Thessaloniki. Obesity Reviews 8 (3) 2007; 36 P066.Impact Factor: 7.995 21. Moudiou T, Papandreou D, Rousso I, Makedou A, Pidonia A, Mavromichalis I, Athanassiadou F. Obesity as a possible risk factor for iron deficiency. Obesity Reviews 8 (3) 2007; 30 P046. Impact Factor: 7.995 22. Papandreou D, Rousso I, Mavromichalis I, Makedou A, Arvanitidou M. Effect of folic acid supplementation on certain cardiovascular risk factors in health Greek children. Clinical Nutrition Supplements 2 2007; 12 O022. Impact Factor: 4.476 23. Papandreou D, Rousso I, Mavromichalis I, Makedou A, Arvanitidou M. Hyperhomocysteinemia in children is normalised by folic acid supplementation. Clinical Nutrition Supplements 2 2007; 151 P309. Impact Factor: 4.476 24. Karabouta Z, Papandreou D, Athanasiadou F, Rousso I. Laboratory and imaging studies in obese children: is there any connection with a family history of obesity, cardiovascular disease and /or type 2 diabetes? Horm Res Pediat 2012; 78(supl 1) P2-d2-566. Impact Factor: 1.573 25. Moudiou T, Papandreou D, Rousso I. Is there any possibility the outpatient clinic attendance to efficiently help obese children? Nutrition, Metabolism and Experimental Approaches 2013-ESPGHAN Journal of Pediatric Gastroenterology and Nutrition 2013 13:-1537. Impact Factor:2.625 26. Karabouta Z, Makedou A, Argiriou D, Papandreou D, et al. Plasminogen activator inhibitor-1(PAI-1), PAI-1 gene polymorphism and family history of cardiovascular disease in relation to metabolic parameters in a sample of obese children. Hormone Research in Pediatrics 2014 82: (suppl 1)P1-D2-118. IF:1.573 27. Karabouta Z, Papandreou D, Makedou A, Rousso I, Athanssiadou F. APOLIPOPROTEIN (A) HS-CRP AND TOTAL FASTING INSULIN LEVELS ARE SIGNIFICANTLY HIGHER IN OBESE CHILDREN WITH FAMILY HISTORY OF CARDIOVASCULAR DISEASE. 5th World Congress in Diabetes, Hypertension and Obesity, 5-7 Nov 2015, Istabul, Turkey. C. Published papers in Greek Journals 1. Nousios G, Chirakis St, Amoutzia A, Patrikiou A, Papandreou D, Fachantidou A. RISK FACTORS ON THE DEVELOPMENT OF CARRIES IN PRE-SCHOOLCHILDREN Primary Health Care 1999; 11 (3):139-142 2. Papandreou D. DIETETIC THERAPY IN GASTROENTERIC DISEASES Nutrtion and Dietetics 2000; 6(3-4):87-97 3. Vougiouka O, Papadopoulou S, Papandreou D, Mpampou S, Tsiskaris G. NUTRITION AND MENOPAUSE STATUS IN TRAINED FEMALE ATHLETES Nutrition and Dietetics 2003;7 (1-2) :36-43 4. Papandreou D, Tsiskaris G, Kalimeri E, Mpampou S, Risos Th, Fachantidou A. FAT METABOLISMDURING PHYSICAL EXERSICE Nutrition and Dietetics, 2003; 7(3-4): 88-98 5. Papandreou D, Mpampou S, Apostolopoulou A, Tsiskaris G. THE ROLE OF CAFFEINE IN ATHLETIC PERFORMANCE. Nutrition and Dietetics, 2003;7(1-2) :25-35 6. Papandreou D, Apostolopoulou A, Mpampou S, Tsiskaris G. BODY COMPOSITION AND ESTIMATION OF NUTRITIONAL STATUS IN SOCCER Nutrition and Dietetics 2003; 7(1-2) :44-50 7. Mpampou S, Papandreou D, Apostolopoulou A, Kalimeri E. NUTRITIONAL STATUS OF INDIVIDUALS WITH CYSTIC FIBROSIS. Nutrition and Dietetics 2004; 8(1-2):21-26 8. Papandreou D, Emporiadou M. NUTRITION AND ASTHMA IN CHILDHOOD Paediatrics 2005; 68 (6): 399-407 9. Papandreou D, Rousso I, Mavromichalis I. EVALUATION OF BODY COMPOSITION, ACTIVITY LEVEL AND DIETARY INTAKES IN OVERWHEIGHT AND OBESE CHILDREN. Nutrition and Dietetics 2005;9(3-4):89-100 10. Papandreou D, Gatzola M, Mavromichalis I. HYPEROMOSYSTEINAIMIA AND RENAL FAILURE. Nutrition and Dietetics 2005; 9(3-4):108-114 11. Papandreou D, Papadopoulou S, Mpampou S, Apostolopoulou A, Tsaklis P. CORRELATION OF BMI AND HIPOSTEOARTHRITIS IN WOMEN AGED 23-60Y. Nutrition and Dietetics 2005; 9(1-2): 39-43 12. Rousso I, Tragiannidis A, Vasiliou G, Papandreou D, Sidiropoulou S, Athanasiadou F. PRECOCIOUS PUBERTY IN A 7-MONTH-OLD INFANT GIRL. CASE REPORT New Paedriatric Years 6 (3) 2006; 201-206 13. Papandreou D, Kalimeri E, Pavlou E. EPILEPSY IN CHILDREN AND KETOGONIC DIET New Paediatric Years 6 2006;105-116 14. Papandreou D, Papantoniou E, Chourdakis M. THE ROLE OF VITAMINS AND TRACE ELEMENTS AT OSTEOPOROSIS Nutrition and Dietetics 2006; 10 (1-2) :46-56 15. Rizos Th, Papandreou D, Zografou M, Efstathiadis P. THE ROLE OF CALCIUM IN NUTRITION AND THE HEALTH VALUE OF THE FOOD INTAKE Nutrition and Dietetics 2006; 10 (1-2):13-30 16. Zacharopoulou G, Papandreou D, Tseprailidou Ch, Griva M, Mavromichalis I. ANTHROPOMETRICAL PARAMETERS IN RELATION TO OBESE CHILDREN 3-16Y. Nutrition and Dietetics 11 (1-2) 2007; 43-47 D) Published Abstracts in Greek Congresses & Journals 1.Papandreou D, Nousios G, Manika I, Patrikiou A, Fachantidou A. THE ROLE OF BLOOD FREE FATTY ACIDS IN PERFORMANCE OF RESISTANT EXERSICE AFTER CONSUMPTION OF A MEAL HIGH IN FAT 5th Scientific Congress of Medical Students of Greece, Aleksandroupoli 1999. 2.Papandreou D, Kotler D, Agin D, Wang J, Pierson R.N. RESULTS OF PROGRESSIVE INCREASE OF WHEIGHT LIFTING ON THE BODY CELL MASS AND MUSCLE STRENGTH IN WOMEN WITH HIV/AIDS 6th Greek Congress of Nutrition and Dietetics, Athens 2000; 158 3. Papandreou D. NUTRITION FOR AGING. 2nd North-Greece Congress of Aesthetics and Nutrition, Thessaloniki 2001; 46 4.Papandreou D. THE ROLE OF IRON AND FOLID ACID IN PREGNANCY. 2nd Scientific Seminar « Research in Gynecology » 2004 5.Tassi P, Papandreou D, Mandalianou Ch, Mastori Ch, Efstathiadis P. NUTRITIONAL STATUS OF CHILDREN AGED 6-16Y IN THESSALONIKI 8th Greek Congress of Nutrition and Dietetics, Athens 2005; 144 6.Papandreou D, Makedou A, Mavromichalis I, Rousso I PREVALENCE OF OBESITY IN HYPERTENSIVE CHILDREN IN THESSALONIKI. 8th Greek Congress of Nutrition and Dietetics, Athens 2005; 141 7. Papandreou D, Mavromicalis I, Zaxaropoulou G, Tseprailidou Ch, Griva M. ESTIMATION OF OVERWHEIGHT AND OBESE CHILD WITH THE USE OF BMI, BODY FAT PERCENTAGE AND WAIST CIRCUMFERENCE IN CHILDREN AGED 3-16y. 3d Scientific Congress of Medical School in Thessaloniki, Thessaloniki, 2005 ; 178 Α132 8. Mpouzouki B, Chondrogianni M, Papandreou D, Efstathiadis P. ESTIMATION OF OBESITY AND NUTRITIONAL ASSESSMENT IN HEALTHY CHILDREN AGED 7-15Y IN THESSALONIKI 6th Greek Medical Congress of Obesity, Thessaloniki 2006 ΠΑ01. 9.Chondrogianni M, Mpouzouki B, Papandreou D, Efstathiadis P. CORRELATION OF ANTHROPOMETRIC INDEXES OF OBESITY AND TELEVISION IN CHILDHOOD 6th Greek Congress for Obesity,, Thessaloniki, 2006 ΑΑ29. 10. Papandreou D, Mandalianou Ch, Mastori Ch, Mavromichalis I CORRELATION OF DIETARY HABBITS AND BODY FAT LEVELS IN NON-EXERSICED CHILDREN AGED 6-15 IN THESSALONIKI Sports Medicine 1 (1) 2006; 79 P22. 11.Papandreou D, Mandalianou X, Mastori Ch, Mavromichalis I. ESTIMATION OF OVERWHEIGHT AND OBESE CHILDREN USING BMI AND BODY FAT PERCENTAGESports Medicine 1 (1) 2006; 78 Ρ21. 12.Hitoglou A, Makedou K, Moschous E, Papandreou D, Kourtis A OBESITY STUDY IN SCHOOL-AGED CHILDREN IN THESSALONIKI 15th Greek Paediatrics Congress, Sithonia Chalkidiki 2007 ΑΑ099. Member of: - EFAD (European Federation of the Association of Dietitian) - Greek Dietetic Association - Cyprus Dietetic Association - American Dietetic Association REFERRES: 1.GARABEDIAN BARED, PROFESSOR, QATAR UNIVERSITY, DOHA, QATAR. E-mail: bsafieh@qu.edu.qa , tel:+97430453498 2.GREGORIOU GEORGE, DEAN, SSE, UNIVERSITY OF NICOSIA, CYPRUS. E-mail: gregoriou.g@unic.ac.cy, tel: +35722841650 3.KIOUMOURTZOGLOU EFTHIMIS, PROFESSOR, SSE, UNIVERSITY OF NICOSIA, CYPRUS. E-mail: kioum@cyta.gr, tel: +35722841659

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Published
2017-10-14
How to Cite
1.
Papandreou D, Karavolias C, Arvaniti F, Kafeza E, Sidawi F. Fasting Ghrelin Levels Are Decreased in Obese Subjects and Are Significantly Related With Insulin Resistance and Body Mass Index. Open Access Maced J Med Sci [Internet]. 2017Oct.14 [cited 2020Nov.26];5(6):699-02. Available from: https://www.id-press.eu/mjms/article/view/oamjms.2017.182
Section
A - Basic Science