The morning normal level of ACTH and cortisol in the plasma of students of both sexes determined by RIA
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Никодијевиќ (Nikodijevikj), Олга (Olga), & Георгиевска (Georgievska), Елизабета (Elizabeta). (2017). The morning normal level of ACTH and cortisol in the plasma of students of both sexes determined by RIA. Medicinska Misla, 27(2), 48–50. Retrieved from


Basal levels of ACT and cortisol in the plasma show diurnal, menstrual and gravidities variations. Several authors have presented mean value with large deviations making difficulties in the clinical interpretation of the results.

In order to get more real picture for the normal amount of ACTH and cortisol in the plasma we did examination of its in healthy volunteer students of both sexes. The blood was taken from 8-12 A.M. and in the women blood was taken 4 times during the menstrual cycle (on the 1., 7., 14., and 21. day from the beginning of the menstrual cycle).

Presented amount for ACTH and in the RIA-CIS-SORIN kit are 38.1 pg/ml ± SD 20 pg/ml. Our examined plasma samples show the following results: mean value vas 53 ± 22.7 pg/ml; on the 1. day = 42 ± 11.8 pg/ml, 7. day = 47.5 ± 4.5 pg/ml, 14. day = 51.5 ± 11.3 pg/ml and 21. day = 63.3 ± 12.5 pg/ml.

Presented value for cortisol in the kit was = 5-25 mcg% and our results show: mean value for men 12.5 ± 3.6 mcg%, and for women = 15.5 ± 9.7 mcg%. For the women during the menstrual cycle value reached its highest level on the 1. day of menstrual cycle.

The results suggest that period of menstrual cycle must be taken into consideration for a correct interpretation of the ACTH and cortisol level in the person.
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