AbstractKinetics of tritium labeled coÐ³tisol was performed in control rats, rats treated with Synacthen Depot and rats treated with Dexamethason i.m. Rats were injected with 2 microCuri directly into the lateral tail vein and timed samples were collected by aorta with heparin Ð°Ñ• an anticoagulans.
The results have shown that treatment with Synacthen led to Ð° smaller half - time and turn over time. Treatment with Dexamethason led to an increase of half-time and decrease of turnover tme.lt could be concluded that change of the functional state of adrenal gland influence the kinetics of radioactive labeled cortisol.
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