Vol. 14 No. 1 (2022): Archives of Public Health
Case Report

Autoimmune Hashimoto thyroiditis with concomitant autoimmune hepatitis

Nevena Manevska
Ss Cyril and Methodius University in Skopje, Faculty of Medicine, Institute of Pathophysiology and Nuclear Мedicine “Acad. Isak S. Tadzer”, Skopje, Republic of North Macedonia
Natasa Stojkovska
Ss Cyril and Methodius University in Skopje, Faculty of Medicine, Institute of Histology and Embryology, Skopje, Republic of North Macedonia
Bio
Ljubica Tasheva
Ss Cyril and Methodius University in Skopje, Faculty of Medicine, Institute of Histology and Embryology, Skopje, Republic of North Macedonia
Marija Jovanovski-Srceva
Ss Cyril and Methodius University in Skopje, Faculty of Medicine, University Clinic for Anesthesia and Reanimation, Skopje, Republic of North Macedonia
Tanja Makazlieva
Ss Cyril and Methodius University in Skopje, Faculty of Medicine, Institute of Pathophysiology and Nuclear Мedicine “Acad. Isak S. Tadzer”, Skopje, Republic of North Macedonia
Sinisha Stojanoski
Ss Cyril and Methodius University in Skopje, Faculty of Medicine, Institute of Pathophysiology and Nuclear Мedicine “Acad. Isak S. Tadzer”, Skopje, Republic of North Macedonia

Published 2022-06-23

Keywords

  • autoimmune thyroiditis,
  • autoimmune hepatitis,
  • antinuclear antibodies,
  • antithyroid antibodies

How to Cite

1.
Manevska N, Stojkovska N, Tasheva L, Jovanovski-Srceva M, Makazlieva T, Stojanoski S. Autoimmune Hashimoto thyroiditis with concomitant autoimmune hepatitis. Arch Pub Health [Internet]. 2022 Jun. 23 [cited 2024 Mar. 29];14(1). Available from: https://www.id-press.eu/aph/article/view/6042

Abstract

So far, the literature data have presented a combination of several autoimmune triggered disease in patients, but the research is scarce and very limited. In this context we present a rare case of autoimmune thyroiditis with a concomitant autoimmune hepatitis. Hashimoto thyroiditis is an autoimmune disorder in which immune cells lead to impairment, destruction of the thyroid hormone producing cells and tissue fibrosis with consecutive primary hypothyroidism. Autoimmune hepatitis is a chronic liver disease with unknown etiology, which is assumed to be T cell mediated condition where immune cells produce autoantibodies responsible for inflammation, destruction and fibrosis of the hepatic parenchyma. In this case report, we discuss the possible correlation in the spectrum of autoimmune diseases concerning Hashimoto thyroiditis and autoimmune hepatitis.

Downloads

Download data is not yet available.

References

  1. Young J L et al. A Case of Hashimoto's Thyroiditis accompanied by autoimmune hepatitis diagnosed with liver biopsy. Journal of Korean Endocrine Society 2009; 24(4): 287-292. DOI: https://doi.org/10.3803/jkes.2009.24.4.287
  2. Sucher E, Sucher R, Gradistanac T, Brandacher G, Schneeberger S, Berg T. Autoimmune hepatitis-immunologically triggered liver pathogenesis-diagnostic and therapeutic strategies. J Immunol Res 2019; 2019: 9437043. DOI: https://doi.org/10.1155/2019/9437043
  3. Ragusa F, Fallahi P, Elia G, Gonnella D, Paparo SR, Giusti C et al. Hashimotos' thyroiditis: Epidemiology, pathogenesis, clinic and therapy. Best Pract Res Clin Endocrinol Metab 2019;33(6):101367. DOI: https://doi.org/10.1016/j.beem.2019.101367
  4. P Caturegli et al. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev 2014;13(4-5):391-397. DOI: https://doi.org/10.1016/j.autrev.2014.01.007
  5. Edit Biró et al. Association of systemic and thyroid autoimmune diseases. Clin Rheumatol 2006;25(2):240-245. DOI: https://doi.org/10.1007/s10067-005-1165-y
  6. Fallahi P, Ruffilli I, Giuggioli D, et al. Associations between Systemic Sclerosis and Thyroid Diseases. Front Endocrinol (Lausanne) 2017;8:266. DOI: https://doi.org/10.3389/fendo.2017.00266
  7. Kristien Boelaert et al. Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease Am J Med 2010;123(2):183-9. DOI: https://doi.org/10.1016/j.amjmed.2009.06.030
  8. Paola Conigliaro et al. Autoimmune thyroid disorders and rheumatoid arthritis: A bidirectional interplay Autoimmun Rev 2020;19(6):102529. DOI: https://doi.org/10.1016/j.autrev.2020.102529
  9. Cárdenas Roldán J, Amaya-Amaya J, Castellanos-de la Hoz J, Giraldo-Villamil J, Montoya-Ortiz G, Cruz-Tapias P, et al. Autoimmune thyroid disease in rheumatoid arthritis: a global perspective. Arthritis 2012;2012:864907. DOI: https://doi.org/10.1155/2012/864907
  10. Atsumasa Komori. Recent updates on the management of autoimmune hepatitis Clin Mol Hepatol 2021; 27(1): 58-69. DOI: https://doi.org/10.3350/cmh.2020.0189
  11. Marcial Sebode et al. Autoimmune hepatitis: From current knowledge and clinical practice to future research agenda. Liver Int 2018; 38(1):15-22. DOI: https://doi.org/10.1111/liv.13458
  12. Weronika Domerecka et al. Etiopathogenesis and diagnostic strategies in autoimmune hepatitis. Diagnostics (Basel). 2021; 11(8): 1418. DOI: https://doi.org/10.3390/diagnostics11081418
  13. Alice Balaceanu et al. Hyposplenism, Hashimoto's autoimmune thyroiditis and overlap syndrome (Celiac Disease and Autoimmune Hepatitis Type 1). Am J Med Sci 2020; 360(3):293-299. DOI: https://doi.org/10.1016/j.amjms.2020.04.022
  14. Qingmin Zeng et al. Relationship between autoimmune liver disease and autoimmune thyroid disease: a cross-sectional study. Scand J Gastroenterol 2020; 55(2):216-221. DOI: https://doi.org/10.1080/00365521.2019.1710766
  15. Tawfik Khoury, Ayman Abu Rmeileh, Liron Yosha, Ariel A. Benson, Saleh Daher, Meir Mizrahi et al. Drug Induced Liver Injury: Review with a focus on genetic factors, tissue diagnosis, and treatment options. J Clin Transl Hepatol. 2015;3(2):99–108. DOI: https://doi.org/10.14218/JCTH.2015.00007
  16. Tiniakos DG, Brain JG, Bury YA et al. Role of histopathology of autoimmune hepatitis. Dig Dis 2015; 33(2):53-64 DOI: https://doi.org/10.1159/000440747