Vol. 11 No. 2 (2019): Archives of Public Health
Clinical Science

Analysis of etiological factors for emergence of endometrial hyperplasia in perimenopause

Aneta Sima
University Clinic of Gynecology and Obstetrics, Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia
Anita Arsovska
University Clinic of Neurology; Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia
Slagjana Simeonova-Krstevska
University Clinic of Gynecology and Obstetrics, Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia
Ana Daneva-Markova
University Clinic of Gynecology and Obstetrics, Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia
Drage Dabeski
University Clinic of Gynecology and Obstetrics, Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia

Published 2019-08-22

Keywords

  • risk factors,
  • perimenopause,
  • endometrial hyperplasia

How to Cite

1.
Sima A, Arsovska A, Simeonova-Krstevska S, Daneva-Markova A, Dabeski D. Analysis of etiological factors for emergence of endometrial hyperplasia in perimenopause. Arch Pub Health [Internet]. 2019 Aug. 22 [cited 2022 Dec. 9];11(2):5-10. Available from: https://www.id-press.eu/aph/article/view/3576

Abstract

The aim of this study was to evaluate the possible reasons for the emergence of endometrial hyperplasia in perimenopause. Material and methods: A total of 71 patients with irregular bleeding were analyzed, at the age of 40-50 years, who should have undergone diagnostic curettage. Depending on the histopathological findings, we divided them into 2 groups: group 1-findings for endometrial hyperplasia, group 2 - atrophic or endometrium with deficient secretory changes. Body mass index (BMI) was determined (obesity defined with BMI >30 kg/m2); we measured blood pressure (cut-off value was 135/90 mmHg), waist circumference (cut-off value was 88 cm) as well as data of anamnesis (age, physical activity, type of diet, smoking cigarettes). All these data were analyzed as etiological factors in the emergence of endometrial hyperplasia.Results: The mean age of patients was 47 years, and the results obtained were very similar in both examined groups. BMI and waist circumference were increased, more than 60% of patients had hypertension, but not all had a statistical significance. Most of them were with completed secondary education, and city living statistically significantly increases the risk of endometrial hyperplasia (p <0.05). As for the lifestyle (physical activity, caloric diet, smoking), the results have shown that a small number of patients are active, almost half of them consume caloric food and smoke, but without a statistical significance.Conclusion: Increased body weight and elevated blood pressure have a major impact on the onset and progression of pathological changes in the endometrium. As clinicians, we should always think of hyperplasia in obesity and patients with hypertension who are irregularly bleeding. At the same time, we should educate them to change the lifestyle in order to prevent gynecological and internistic morbidity.

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