Primary Fallopian Tube Carcinoma: A Case Report and Literature Review

Meral Rexhepi, Elizabeta Trajkovska, Hysni Ismaili, Florin Besimi, Nagip Rufati

Abstract


BACKGROUND: Primary fallopian tube carcinoma (PFTC) is a rare tumour of the female genital tract with an incidence of 0.1-1.8% of all genital malignancies, and it is very difficult to diagnose preoperatively, because of its non-specific symptomatology. In most cases, it is an intraoperative finding or a histopathological diagnosis. It is a tumour that histologically and clinically resembles epithelial ovarian cancer.

CASE PRESENTATION: We are reporting a case of a 62-year-old, postmenopausal women with primary fallopian tube carcinoma of the right fallopian tube in stage IA. The patient has lower abdominal pain, watery vaginal discharge and repeated episodes of bleeding from the vagina. The clinical and radiological findings suggested a right adnexal tumour with elevated CA-125 levels. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy and peritoneal washing were performed. Pathologic confirmation of primary serous cystadenocarcinoma of the right fallopian tube was made. Peritoneal washings were negative for malignancy. FIGO stage was considered as IA, and the patient received no courses of chemotherapy and postoperative radiation because she refused it. Ten months after initial surgery, the patient is alive and in good condition.

CONCLUSION: Cytoreduction surgery followed by adequate cycles of chemotherapy is an important strategy to improve patients’ prognosis.

Keywords


fallopian tube; serous cystadenocarcinoma; post-menopausal female; intraoperative assessment; histopathological diagnosis

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References


Kalampokas E, Kalampokas T, Tourountous I. Primary fallopian tube carcinoma. Eur J Obstet Gynecol Reprod Biol. 2013: 169:155-61. https://doi.org/10.1016/j.ejogrb.2013.03.023 PMid:23622731

Lau HY, Chen YJ, Yen MS, et al. Primary fallopian tube carcinoma: a clinicopathologic analysis and literature review. J Chin Med Assoc. 2013;76(10):583-7. https://doi.org/10.1016/j.jcma.2013.06.010 PMid:23890835

Ma Y, Duan W., Clinical and survival analysis of 36 cases of primary fallopian tube carcinoma. World Journal of Surgical Oncology. 2014;12(1):311. https://doi.org/10.1186/1477-7819-12-311 PMid:25307473 PMCid:PMC4200227

Pectasides D, Pectasides E, Economopoulos T. Fallopian tube carcinoma: a review. Oncologist. 2006; 11(8):902-12. https://doi.org/10.1634/theoncologist.11-8-902 PMid:16951394

Horng HC, Teng SW, Huang BS, et al. Primary fallopian tube cancer: domestic data and up-to-date review. Taiwan J. Obstet Gynecol. 2014; 53(3):287-92. https://doi.org/10.1016/j.tjog.2014.07.003 PMid:25286779

Hariprasad PSH, Srinivas T, Shetty KJJ. Primary bilateral fallopian tube carcinoma the report of a single case with review of the literature. Clin Diagn Res. 2013;7(5):930-2. https://doi.org/10.7860/jcdr/2013/5483.2980

Orthmann EG. Primareskarzinom in Einertuberkulosen. Ztschr Geburtsh Gynaek. 1888; 15:212.

Riska A, Leminen A. Determinants of incidence of primary fallopian tube carcinoma (PFTC). Methods Mol Biol. 2009;472:387-96. https://doi.org/10.1007/978-1-60327-492-0_18 PMid:19107444

Berek S.J, Crum Ch, Friedlander M, Cancer of the ovary, fallopian tube, and peritoneum International Journal of Gynecology & Obstetrics. 2015; 131(2):S111–S122.

Mladenovic-Segedi L. Primary fallopian tube carcinoma. Med Pregled. 2009; 62(1-2): 31-6 https://doi.org/10.2298/MPNS0902031M PMid:19514598

Howitt BE, Hanamornroongruang S, Lin DI, Conner JE, Schulte S, Horowitz N, Crum CP, Meserve EE. Evidence for a dualistic model of high-grade serous carcinoma: BRCA mutation status, histology, and tubal intraepithelial carcinoma. Am J Surg Pathol. 2015;39(3):287-93. https://doi.org/10.1097/PAS.0000000000000369 PMid:25581732

Quartuccio SM, Karthikeyan S, Eddie SL et al., Mutant p53 expression in fallopian tube epithelium drives cell migration. Int J Cancer. 2015; 137(7):1528-38. https://doi.org/10.1002/ijc.29528 PMid:25810107 PMCid:PMC4503498

Gomes FV, Dias JL, Lucas R, Cunha TM. Primary fallopian tube carcinoma: review of MR imaging findings. Insights Imaging. 2015; 6:431–439. https://doi.org/10.1007/s13244-015-0416-y PMid:26150249 PMCid:PMC4519813

Lau H-Y. Primary fallopian tube carcinoma: a clinicopathologic analysis and literature review. J Chin Med Assoc. 2013;76(10):583-7. https://doi.org/10.1016/j.jcma.2013.06.010 PMid:23890835

Jeung ICh, Lee YS, Lee HN, et al. Primary Carcinoma of the Fallopian Tube: Report of Two Cases with Literature Review, Cancer Research and Treatment. 2009; 41(2):113-6. https://doi.org/10.4143/crt.2009.41.2.113 PMid:19707511 PMCid:PMC2731206

Puig F, Lapresta M, Lanzon A, Crespo R. Fallopian tube carcinoma: incidental finding during surgery for acute pelvic inflammatory disease--case report. Eur J Gynaecol Oncol. 2006; 27(5):526-7. PMid:17139993

Nordin AJ. Primary carcinoma of the fallopian tube: a 20-year literature review. Obstet Gynecol Surv. 1994; 49(5):349-61. https://doi.org/10.1097/00006254-199405000-00026 PMid:8015756

Kalyani R, Kumar ML, Srikantia SH. Primary adenocarcinoma of fallopian tube-a case report. Indian J Pathol Microbiol. 2005;48(2):219-21. PMid:16758673

Tahiri Elousrouti L, Erragad FZ, Jayi S, et al. Primary Adenocarcinoma of the Fallopian Tube: Report of Two Cases. Journal of Clinical Case Reports. 2016; 6:5.

Moore KN, Moxley KM, Fader AN, et al. Serous fallopian tube carcinoma: a retrospective, multi-institutional case-control comparison to serous adenocarcinoma of the ovary. Gynecol Oncol. 2007;107:398–403. https://doi.org/10.1016/j.ygyno.2007.09.027 PMid:17997146

Jeung IC, Lee YS, Lee HN, Park EK. Primary carcinoma of the fallopian tube: report of two cases with literature review. Cancer Res Treat. 2009;41(2):113-6. https://doi.org/10.4143/crt.2009.41.2.113 PMid:19707511 PMCid:PMC2731206

Horng HC, Teng SW, Huang BS, et al. Primary fallopian tube cancer: domestic data and up-to-date review. Obstet Gynecol. 2014;53(3):287-92. https://doi.org/10.1016/j.tjog.2014.07.003

Koo, Yu-Jin K, Kyoung-Shil I, Yong-Soon K. Primary fallopian tube carcinoma: a clinicopathological analysis of a rare entity, International Journal of Clinical Oncology. 2011; 16(1):45-49. https://doi.org/10.1007/s10147-010-0128-8 PMid:20878435

Huber-Buchholz MM, Buchholz NP, Staehelin JJ. Analysis of 23 cases of primary carcinoma of the fallopian tube over 50 years. Obstet Gynaecol Res. 1996;22(3):193-9. https://doi.org/10.1111/j.1447-0756.1996.tb00966.x

Cheng Horng H, Teng S.W, Huang B. Primary fallopian tube cancer: Domestic data and up-to-date review, Taiwanese Journal of Obstetrics and Gynecology. 2014; 53(3):287–292. https://doi.org/10.1016/j.tjog.2014.07.003 PMid:25286779

Chaudhry S, Hussain R, Zuberi MM, Zaidi ZJ. Rare primary fallopian tube carcinoma; a gynaecologist's dilemma. Pak Med Assoc. 2016;66(1):107-10.

Chaudhry S, Hussain R, Zuberi MM, Zaidi Z. Rare primary fallopian tube carcinoma; a gynaecologist's dilemma. J Pak Med Assoc. 2016;66(1):107-10. PMid:26712194

Hu, CY, Taymor, ML, and Hertig, AT. Primary carcinoma of the fallopian tube. Am J Obstet Gynecol. 1950; 50: 58–67. https://doi.org/10.1016/0002-9378(50)90341-3

Sedlis A. Carcinoma of the fallopian tube. Surg Clin North Am. 1978; 58: 121–129. https://doi.org/10.1016/S0039-6109(16)41439-8

Saida T, Tanaka YO, Matsumoto K, Satoh T, Yoshikawa H, Minami M. Revised FIGO staging system for cancer of the ovary, fallopian tube, and peritoneum: important implications for radiologists. Jpn J Radiol. 2016;34(2):117-24. https://doi.org/10.1007/s11604-015-0513-3 PMid:26696400

Ludovisi M, De Blasis I, Virgilio B, Fischerova D, Franchi D, Pascual MA, Savelli L, Epstein E, Van Holsbeke C, Guerriero S, Czekierdowski A, Zannoni G, Scambia G, Jurkovic D, Rossi A, Timmerman D, Valentin L, Testa AC. Imaging in gynecological disease (9): clinical and ultrasound characteristics of tubal cancer. Ultrasound Obstet Gynecol. 2014;43(3):328-35. https://doi.org/10.1002/uog.12570 PMid:23893713

Balaya. V, Metzger U, Lecuru F. Ultrasonographic features in the preoperative diagnosis of primitive fallopian tube carcinoma. J Gynecol Obstet Biol Reprod (Paris). 2016;45(1):11-20. https://doi.org/10.1016/j.jgyn.2015.06.023 PMid:26183176

Katabathina VS, Amanullah FS, Menias CO, Chen MM, Valente PT, Chintapalli KN, Prasad SR. Extrauterine Pelvic Serous Carcinomas: Current Update on Pathology and Cross-sectional Imaging Findings. Radiographics. 2016;36(3):918-32. https://doi.org/10.1148/rg.2016150130 PMid:27163599




DOI: http://dx.doi.org/10.3889/oamjms.2017.044

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